Pharmacokinetics of Cyadox and Its Major Metabolites in Swine After Intravenous and Oral Administration

Journal of Integrative Agriculture

Volumn 12, Issue 3, 2013, Pages 495-501

  Zhao, Ning ^a   Wang, Lin ^a   Lu, Xiao xiong ^a   Jia, Hui qin ^a   Fang, Bing hu ^a   Zeng, Zhen ling ^a   Ding, Huan zhong ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Cyadox; LC MS MS; Metabolites; Pharmacokinetics; Swine

Indexed keywords

SUIDAE;

EID: 84875780370     PISSN: 20953119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-3119(13)60250-6     Document Type: Article

References (18)

1. Benet LZ, Galeazzi RL Noncompartmental determination of the steady-state volume of distribution. Journal of Pharmaceutical Sciences 1979, 68:1071-1074.
2. Cutler DJ Theory of the absorption time, an adjunct to conventional bioavailability studies. Journal of Pharmacy and Pharmacology 1978, 30:476-478.
3. Ding MX, Wang YL, Zhu HL, Yuan ZH Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets. Journal of Animal Science 2006, 84:2367-2373.
4. Fang GJ, He QH, Zhou SQ, Wang DJ, Zhang YL, Yuan ZH Subchronic oral toxicity study with cyadox in Wistar rats. Food and Chemical Toxicology 2006, 44:36-41.
5. Gibaldi M, Perrier D Pharmacokinetics 1982, Marrcel Dekker, New York.
6. de Graaf GJ, Spierenburg TJ Liquid chromatographic determination of cyadox in medicated feeds and in the contents of the porcine gastrointestinal tract with fluorescence detection. Journal of Chromatography 1988, 447:244-248.
7. He QH, Fang GJ, Wang YL, Wei ZC, Wang DJ, Zhou SQ, Fan SX, Yuan ZH Experimental evaluation of cyadox phototoxicity to Balb/c mouse skin. Photodermatology Photoimmunology and Photomedicine 2006, 22:100-104.
8. Huang L. 2005. Effectiveness and safety studies of cyadox in broilers. Ph D thesis, Huazhong Agricultural University, Wuhan, China. (in Chinese).
9. Huang LL, Wang YL, Tao YF, Chen DM, Yuan ZH Development of high performance liquid chromatographic methods for the determination of cyadox and its metabolites in plasma and tissues of chicken. Journal of Chromatography (B - Analytical Technologies in the Biomedical and Life Sciences) 2008, 874:7-14.
10. Liu ZY, Huang LL, Dai MH, Chen DM, Tao YF, Wang YL, Yuan ZH Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2009, 23:2026-2034.
11. Qiu Y. 2003. Pharmacokinetics residue depletion of cyadox in swine. Ph D thesis, Huazhong Agricultural University, Wuhan, China. (in Chinese).
12. Sestakova I, Kopanica M Determination of cyadox and its metabolites in plasma by adsorptive voltammetry. Talanta 1988, 35:816-818.
13. Tokosova M The effect of cyadox and virginiamycin on Marek's disease in chickens. Veterinarni Medicina 1990, 35:105-112.
14. de Vries H, Bojarski J, Donker AA, Bakri A, Beyersbergen van Henegouwen GM Photochemical reactions of quindoxin, olaquindox, carbadox and cyadox with protein, indicating photoallergic properties. Toxicology 1990, 63:85-95.
15. Xu N, Huang LL, Liu ZL Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 2011, 25:2333-2344.
16. Yamaoka K, Nakagawa T, Uno T Statistical moments in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics 1978, 6:547-558.
17. Yin J. 2003. Pharmacokinetics residue depletion of cyadox in carp. MSc thesis, Huazhong Agricultural University, Wuhan, China (in Chinese).
18. Zhang YL, Huang LL, Chen DM, Fan SX, Wang YL, Tao YF, Yuan ZH Development of HPLC methods for the determination of cyadox and its main metabolites in goat tissues. Analytical Sciences 2005, 21:1495-1499.