Tissue deposition and residue depletion of cyadox and its three major metabolites in pigs after oral administration

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 39, 2013, Pages 9510-9515

  Li, Yafei ^a   Zhao, Ning ^b   Zeng, Zhenling ^a   Gu, Xiaoyan ^a   Fang, Binghu ^a   Yang, Fan ^c   Zhang, Bingxu ^a   Ding, Huanzhong ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b Center for Animal Husbandry and Veterinary Technology Promotion   (China)

^c HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cyadox; Elimination; Metabolites; Pig; Residue

Indexed keywords

CONCENTRATION-TIME; CYADOX; ELIMINATION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; ORAL ADMINISTRATION; PIG; QUINOXALINE-2-CARBOXYLIC ACIDS; RESIDUE;

BIOMOLECULES; DEPOSITION; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; METABOLITES; TISSUE;

TISSUE ENGINEERING;

2 QUINOXALINECARBOXYLIC ACID; BIOLOGICAL MARKER; CIADOX; DRUG RESIDUE; FOOD ADDITIVE; QUINOXALINE DERIVATIVE; QUINOXALINE-2-CARBOXYLIC ACID;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOTRANSFORMATION; CHEMISTRY; CHINA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS BREEDING; FOOD CONTAMINATION; FOOD CONTROL; GROWTH, DEVELOPMENT AND AGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; MALE; MEAT; METABOLISM; METHODOLOGY; RANDOMIZED CONTROLLED TRIAL; SWINE; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; VALIDATION STUDY;

ANIMALS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSSES, GENETIC; DRUG RESIDUES; FOOD ADDITIVES; FOOD CONTAMINATION; FOOD INSPECTION; KIDNEY; MALE; MEAT; QUINOXALINES; SUS SCROFA; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84885408085     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf4028602     Document Type: Article

References (27)

1. Broz., J.; Sevcik, B.; Hebky, T. Growth promoting activity of cyadox in piglet rearing. Z. Tierphysiol., Tierernaehr. Futtermittelkd. 1978, 41, 237-242.
2. De Graaf, G. J.; Spierenburg, T. J. Liquid chromatographic determination of cyadox in medicated feeds and in the contents of the porcine gastrointestinal tract with fluorescence detection. J. Chromatogr. 1988, 447, 244-248.
3. Zhu, H.; Yuan, Z.; Wang, Y.; Qiu, Y.; Fan, S. The effect of cyadox supplementation on metabolic hormones and epidermal growth factor in pigs. Anim. Sci. 2006, 82, 345-350.
4. Fang, G.; He, Q.; Zhou, S.; Wang, D.; Zhang, Y.; Yuan, Z. Subchronic oral toxicity study with cyadox in Wistar rats. Food Chem. Toxicol. 2006, 44, 36-41.
5. Wang, X.; He, Q. H.; Wang, Y. L.; Ihsan, A.; Huang, L. L.; Zhou, W.; Su, S. J.; Liu, Z. L.; Yuan, Z. H. A chronic toxicity study of cyadox in Wistar rats. Regul. Toxicol. Pharmacol. 2011, 59, 324-533.
6. He, Q.; Fang, G.; Wang, Y.; Wei, Z.; Wang, D.; Zhou, S.; Fan, S.; Yuan, Z. Experimental evaluation of cyadox phototoxicity to Balb/c mouse skin. Photodermatol., Photoimmunol. Photomed. 2006, 22, 100- 104.
7. European Commission (EC). European Commission Regulation No. 2788/98. Off. J. Eur. Communities: Legis. 1998, 347, 32.
8. Liu, Z.; Huang, L.; Dai, M.; Chen, D.; Tao, Y.; Wang, Y.; Yuan, Z. Metabolism of cyadox in rat, chicken and pig liver microsomes and identification of metabolites by accurate mass measurements using electrospray ionization hybrid ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23, 2026-2034.
9. Xu, N.; Huang, L.; Liu, Z.; Pan, Y.; Wang, X.; Tao, Y.; Chen, D.; Wang, Y.; Peng, D.; Yuan, Z. Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2011, 25, 2333-2344.
10. Wu, H.; Li, L.; Shen, J.; Wang, Y.; Liu, K.; Zhang, S. In vitro metabolism of cyadox in rat, chicken and swine using ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 2012, 67-68, 175-185.
11. Huang, C.; Lei, H.; Zhao, X.; Tang, H.; Wang, Y. Metabolic influence of acute cyadox exposure on kunming mice. J. Proteome Res. 2013, 12, 537-545.
12. Zhang, Y.; Huang, L.; Chen, D.; Fan, S.; Wang, Y.; Tao, Y.; Yuan, Z. Development of HPLC methods for the determination of cyadox and its main metabolites in goat tissues. Anal. Sci. 2005, 21, 1495-1499.
13. Wu, Y.; Yu, H.; Wang, Y.; Huang, L.; Tao, Y.; Chen, D.; Peng, D.; Liu, Z.; Yuan, Z. Development of a high-performance liquid chromatography method for the simultaneous quantification of quinoxaline-2-carboxylic acid and methyl-3-quinoxaline-2-carboxylic acid in animal tissues. J. Chromatogr., A 2007, 1146, 1-7.
14. Huang, L.; Wang, Y.; Tao, Y.; Chen, D.; Yuan, Z. Development of high performance liquid chromatographic methods for the determination of cyadox and its metabolites in plasma and tissues of chicken. J. Chromatogr., B 2008, 874, 7-14.
15. Cheng, L.; Wang, Z.; Shen, J.; Li, L.; Wu, H.; Zhang, S. A specific UPLC-ESI-MS/MS method for analysis of cyadox and its three main metabolites in fish samples. Anal. Methods 2012, 4, 217- 221.
16. Yan, D.; He, L.; Zhang, G.; Fang, B.; Yong, Y.; Li, Y. Simultaneous Determination of Cyadox and Its Metabolites in Chicken Tissues by LC-MS/MS. Food Analytical Methods 2012, 1-9.
17. He, L.; Liu, K.; Su, Y.; Zhang, J.; Liu, Y.; Zeng, Z.; Fang, B.; Zhang, G. Simultaneous determination of cyadox and its metabolites in plasma by high-performance liquid chromatography tandem mass spectrometry. J. Sep. Sci. 2011, 34, 1755-1762.
18. Ding, H.; Liu, Y.; Zeng, Z.; Si, H.; Liu, K.; Liu, Y.; Yang, F.; Li, Y.; Zeng, D. Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration. Res. Vet. Sci. 2012, 93, 374-377.
19. Li, G.; Yang, F.; He, L.; Ding, H.; Sun, N.; Liu, Y.; Liu, Y.; Shan, Q.; Li, Y.; Zeng, Z. Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration. Res. Vet. Sci. 2012, 93, 1380-1386.
20. MacIntosh, A. I.; Lauriault, G.; Neville, G. A. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J.Assoc. Off. Anal. Chem. 1985, 68, 665-671.
21. Cheng, L.; Shen, J.; Wang, Z.; Jiang, W.; Zhang, S. A sensitive and specific ELISA for determining a residue marker of three quinoxaline antibiotics in swine liver. Anal. Bioanal. Chem. 2013, 405, 2653-2659.
22. Lauridsen, M.; Lund, C.; Jacobsen, M. Determination and depletion of residues of carbadox, tylosin, and virginiamycin in kidney, liver, and muscle of pigs in feeding experiments. J.Assoc. Off. Anal. Chem. 1988, 71, 921-925.
23. Huang, L. Effectiveness and safety studies of cyadox in broilers. Ph.D. Dissertation, Huazhong Agricultural University, Hubei, China, 2005 (in Chinese).
24. Bosin, T.; Maickel, R. Mass spectra of carcinogenic 4- hydroxylaminoquinoline n-oxides. Res. Commun. Chem. Pathol. Pharmacol. 1973, 6, 813-820.
25. Negishi, T.; Tanaka, K.; Hayatsu, H. Mutagenicity of carbadox and several quinoxaline 1, 4-dioxide derivatives. Chem. Pharm. Bull. 1980, 28, 1347-1349.
26. Hashimoto, T.; Negishi, T.; Namba, T.; Hayakawa, S.; Hayatsu, H. Mutagenicity of quinoline derivatives and analogs: Quinoxaline 1, 4- dioxide is a potent mutagen. Chem. Pharm. Bull. 1979, 27, 1954-1956.
27. Patterson, L. H. Bioreductively activated antitumor N-oxides: The case of AQ4N, a unique approach to hypoxia-activated cancer chemotherapy. Drug Metab. Rev. 2002, 34, 581-592.