Idiopathic hyperaldosteronism: Analysis of aldosterone synthase gene

Biomedicine and Pharmacotherapy

Volumn 54, Issue SUPPL. 1, 2000, Pages 77s-79s

  Miyamori, I ^a   Inaba, S ^a   Hatakeyama, H ^a   Taniguchi, N ^a   Takeda, Y ^b  

^a UNIVERSITY OF FUKUI   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

CYP11B2; Idiopathic hyperaldosteronism; P450aldo

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN;

ADRENAL HYPERPLASIA; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; HYPERALDOSTERONISM; IDIOPATHIC DISEASE; LEUKOCYTE; PRIORITY JOURNAL; PROMOTER REGION; ZONA GLOMERULOSA;

EID: 0033920778     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(00)80017-7     Document Type: Article

References (10)

1. Miyamori I, Matsubara T, Takeda R. Idiopathic hyperaldosteronism. In: Takeda, Mitamori, eds. Controversies on adrenal hormone disorders. Amsterdam: Elsevier Science; 1989. p. 111.
2. Saruta T. Disorders of mineralocorticoid hormone. Folia Endocrinol Jpn 1999 ; Suppl : 722.
3. Fardella CE, Rodoriquez H, Hum DW, Mellon SH, Miller WL. Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: A model for low-renin hypertension? J Clin Endocrinol Metab 1995 ; 80 : 1040.
4. Cover CM, Wang JM, St Lezin E, Kurtz TW, Mellon SH. Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension. J Biol Chem 1995 ; 14 ; 270 : 16555.
5. Takeda Y, Furukawa K, Inaba S, Miyamori I, Mabuchi H. Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism. J Clin Endocrinol Metab 1999 ; 84 : 1633.
6. Tamaki S, Iwai N, Tsujita Y, Kinoshita M. Genetic polymorphism of CYP11B2 gene and hypertension in the Japanese. Hypertension 1999 ; 33 : 266.
7. Jonsson JR, Klemm SA, Tunny TJ, Stowasser M, Gordon RD. A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension. Biochem Biophys Res Commun 1995 ; 207 : 565.
8. Carroll J, Dluhy R, Fallo F, Pistorello M, Bradwin G, Gomez-Sanchez CE, et al. Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications. J Clin Endocrinol Metab 1996 ; 81 : 4310-2.
9. Clyne CD, Zhang Y, Slutsker L, Mathis JM, White PC, Rainey WE. Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. Mol Endocrinol 1997 ; 11 : 638-49.
10. LeHoux JG, Lefebvre A. Transcriptional activity of the hamster CYP11B2 promoter in NCI-H295 cells stimulated by angiotensin II, potassium, forskolin and bisindolylmaleimide. J Mol Endocrinol 1998 ; 20 : 183-91.