Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly

Biochemistry

Volumn 51, Issue 1, 2012, Pages 126-137

  Abelein, Axel ^a   Bolognesi, Benedetta ^b   Dobson, Christopher M ^b   Gräslund, Astrid ^a   Lendel, Christofer ^b,c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; ALZHEIMER'S DISEASE; AMYLOID FIBRIL; CONFORMATIONAL CHANGE; CONFORMATIONAL PREFERENCES; HYDROPHOBIC ATTRACTION; MECHANISM OF ACTION; MOLECULAR MECHANISM; NEURODEGENERATIVE DISORDERS; PARKINSON'S DISEASE; PROTEIN AGGREGATES; REPRESENTATIVE COMPOUND; SMALL ORGANIC MOLECULES;

CONFORMATIONS; GLYCOPROTEINS; HYDROPHOBICITY; NEURODEGENERATIVE DISEASES; SELF ASSEMBLY; SURFACE ACTIVE AGENTS;

PROTEINS;

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CONFORMATIONAL TRANSITION; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING;

AMYLOID BETA-PEPTIDES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; CONGO RED; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; NANOSTRUCTURES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXAZINES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; SCATTERING, RADIATION; SMALL MOLECULE LIBRARIES; SURFACE-ACTIVE AGENTS;

EID: 84856873078     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201745g     Document Type: Article

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