Chemical endoplasmic reticulum chaperone alleviates doxorubicin-induced cardiac dysfunction

Circulation Research

Volumn 118, Issue 5, 2016, Pages 798-809

  Fu, Hai Ying ^a   Sanada, Shoji ^a   Matsuzaki, Takashi ^a   Liao, Yulin ^b   Okuda, Keiji ^a   Yamato, Masaki ^a   Tsuchida, Shota ^a   Araki, Ryo ^a   Asano, Yoshihiro ^a   Asanuma, Hiroshi ^c   Asakura, Masanori ^d   French, Brent A ^e   Sakata, Yasushi ^a   Kitakaze, Masafumi ^d   Minamino, Tetsuo ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c KYOTO PREFECTURAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^e University of Virginia   (United States)

Author keywords

Apoptosis; Cardiac dysfunction; Doxorubicin; Endoplasmic reticulum chaperone; Endoplasmic reticulum stress

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 6; BUTYRIC ACID; CASPASE 12; CHAPERONE; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 78; X BOX BINDING PROTEIN 1; 4-PHENYLBUTYRIC ACID; ANTINEOPLASTIC AGENT; ARYLBUTYRIC ACID DERIVATIVE;

ADENO ASSOCIATED VIRUS 9; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CANCER THERAPY; CARDIOTOXICITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; HEART DILATATION; HEART DISEASE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CARDIAC MUSCLE CELL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; HEART FAILURE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; DOXORUBICIN; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HEART FAILURE; MALE; MICE; MICE, INBRED ICR; MYOCYTES, CARDIAC; PHENYLBUTYRATES; RATS;

EID: 84956963882     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.307604     Document Type: Article

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