Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 5, 2016, Pages 1197-1201

  Poulin, Myles B ^a   Schneck, Jessica L ^b   Matico, Rosalie E ^b   McDevitt, Patrick J ^b   Huddleston, Michael J ^b   Hou, Wangfang ^b   Johnson, Neil W ^b   Thrall, Sara H ^b   Meek, Thomas D ^b,c   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; HISTONE H3; ISOTOPE; LYSINE; NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN 2; NUCLEOPHILE; S ADENOSYLMETHIONINE; SULFUR 36; TRANSFERASE; TRITIUM; UNCLASSIFIED DRUG; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; REPRESSOR PROTEIN; WHSC1 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; CHEMICAL LABELING; CHEMICAL MODEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME KINETICS; FEMALE; HELA CELL LINE; HISTONE METHYLATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOPHILICITY; NUCLEOSOME; PHASE TRANSITION; PRIORITY JOURNAL; QUANTUM CHEMISTRY; REACTION ANALYSIS; TRANSITION STATE; CHEMISTRY; METABOLISM; METHYLATION; MOLECULAR MODEL;

CATALYSIS; HELA CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; LYSINE; METHYLATION; MODELS, MOLECULAR; REPRESSOR PROTEINS;

EID: 84956953910     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1521036113     Document Type: Article

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