A basic post-SET extension of NSDs is essential for nucleosome binding in vitro

Journal of Biomolecular Screening

Volumn 19, Issue 6, 2014, Pages 928-935

  Allali Hassani, Abdellah ^a   Kuznetsova, Ekaterina ^a   Hajian, Taraneh ^a   Wu, Hong ^a   Dombrovski, Ludmila ^a   Li, Yanjun ^a   Gräslund, Susanne ^a   Arrowsmith, Cheryl H ^a,b   Schapira, Matthieu ^a   Vedadi, Masoud ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

cancer; histone methyltransferase; MMSET; Sotos syndrome; WHSC1; WHSC1L1

Indexed keywords

NSD1 PROTEIN; NSD2 PROTEIN; NSD3 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; BUFFER; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE; LYSINE; NSD1 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUCLEOSOME; PROTEIN BINDING; REPRESSOR PROTEIN; SIGNAL PEPTIDE; WHSC1 PROTEIN, HUMAN; WHSC1L1 PROTEIN, HUMAN; CELL NUCLEUS RECEPTOR; HISTONE H3; PROTEIN NSD1; PROTEIN NSD2; PROTEIN NSD3;

ARTICLE; ENZYME SPECIFICITY; HUMAN; IN VITRO STUDY; KINETICS; MOLECULAR MODEL; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; CHEMISTRY; GENE DELETION; IC50; MOLECULAR CLONING; MUTATION; METHYLATION; PROTEIN EXPRESSION; SCREENING;

BUFFERS; CLONING, MOLECULAR; GENE DELETION; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LYSINE; MODELS, MOLECULAR; MUTATION; NUCLEAR PROTEINS; NUCLEOSOMES; PROTEIN BINDING; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84904888720     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114525854     Document Type: Article

References (35)

1. Copeland R. A., Solomon M. E., Richon V. M.. Protein Methyltransferases as a Target Class for Drug Discovery. Nat. Rev. Drug Discov. 2009 ; 8: 724-732
2. Kelly T. K., De Carvalho D. D., Jones P. A.. Epigenetic Modifications as Therapeutic Targets. Nat. Biotechnol. 2010 ; 28: 1069-1078
3. Morishita M., di Luccio E.. Cancers and the NSD Family of Histone Lysine Methyltransferases. Biochim. Biophys. Acta. 2011 ; 1816: 158-163
4. Wagner E. J., Carpenter P. B.. Understanding the Language of Lys36 Methylation at Histone H3. Nat. Rev. Mol. Cell Biol. 2012 ; 13: 115-126
5. Li Y., Trojer P., Xu C. F., et al. The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate. J. Biol. Chem. 2009 ; 284: 34283-34295
6. Kuo A. J., Cheung P., Chen K., et al. NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming. Mol. Cell. 2011 ; 44: 609-620
7. Morishita M., di Luccio E.. Structural Insights into the Regulation and the Recognition of Histone Marks by the SET Domain of NSD1. Biochem. Biophys. Res. Commun. 2011 ; 412: 214-219
8. Huang Z., Wu H., Chuai S., et al. NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma. Cancer Res. 2013 ; 73: 6277-6280
9. Kim J. Y., Kee H. J., Choe N. W., et al. Multiple-Myeloma-Related WHSC1/MMSET Isoform RE-IIBP Is a Histone Methyltransferase with Transcriptional Repression Activity. Mol. Cell. Biol. 2008 ; 28: 2023-2034
10. Pei H., Zhang L., Luo K., et al. MMSET Regulates Histone H4K20 Methylation and 53BP1 Accumulation at DNA Damage Sites. Nature. 2011 ; 470: 124-128
11. Nimura K., Ura K., Shiratori H., et al. A Histone H3 Lysine 36 Trimethyltransferase Links Nkx2-5 to Wolf-Hirschhorn Syndrome. Nature. 2009 ; 460: 287-291
12. Edmunds J. W., Mahadevan L. C., Clayton A. L.. Dynamic Histone H3 Methylation during Gene Induction: HYPB/Setd2 Mediates All H3K36 Trimethylation. EMBO J. 2008 ; 27: 406-420 (Pubitemid 351161656)
13. Kurotaki N., Imaizumi K., Harada N., et al. Haploinsufficiency of NSD1 Causes Sotos Syndrome. Nat. Genet. 2002 ; 30: 365-366
14. Titomanlio L., Romano A., Conti A., et al. Mild Wolf-Hirschhorn Phenotype and Partial GH Deficiency in a Patient with a 4p Terminal Deletion. Am. J. Med. Genet. A 2004, 127A.: 197-200
15. Cerveira N., Correia C., Doria S., et al. Frequency of NUP98-NSD1 Fusion Transcript in Childhood Acute Myeloid Leukaemia. Leukemia. 2003 ; 17: 2244-2247 (Pubitemid 37428398)
16. La Starza R., Gorello P., Rosati R., et al. Cryptic Insertion Producing Two NUP98/NSD1 Chimeric Transcripts in Adult Refractory Anemia with an Excess of Blasts. Genes Chromosomes Cancer. 2004 ; 41: 395-399 (Pubitemid 39488498)
17. Chesi M., Nardini E., Lim R. S., et al. The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3 and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts. Blood. 1998 ; 92: 3025-3034 (Pubitemid 28492306)
18. Rosati R., La Starza R., Veronese A., et al. NUP98 Is Fused to the NSD3 Gene in Acute Myeloid Leukemia Associated with t(8;11)(p11.2;p15). Blood. 2002 ; 99: 3857-3860 (Pubitemid 34534564)
19. Keats J. J., Maxwell C. A., Taylor B. J., et al. Overexpression of Transcripts Originating from the MMSET Locus Characterizes All t(4;14)(p16;q32)-Positive Multiple Myeloma Patients. Blood. 2005 ; 105: 4060-4069 (Pubitemid 40656156)
20. Jain N., Rossi A., Garcia-Manero G.. Epigenetic Therapy of Leukemia: An Update. Int. J. Biochem. Cell Biol. 2009 ; 41: 72-80
21. Smith L. T., Otterson G. A., Plass C.. Unraveling the Epigenetic Code of Cancer for Therapy. Trends Genet. 2007 ; 23: 449-456 (Pubitemid 47259577)
22. Zhang J. H., Chung T. D., Oldenburg K. R.. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen. 1999 ; 4: 67-73 (Pubitemid 29278954)
23. Bojanowski K., Lelievre S., Markovits J., et al. Suramin Is an Inhibitor of DNA Topoisomerase II In Vitro and in Chinese Hamster Fibrosarcoma Cells. Proc. Natl. Acad. Sci. U. S. A. 1992 ; 89: 3025-3029
24. Cherblanc F. L., Chapman K. L., Brown R., et al. Chaetocin Is a Nonspecific Inhibitor of Histone Lysine Methyltransferases. Nat. Chem. Biol. 2013 ; 9: 136-137
25. Richon V. M., Johnston D., Sneeringer C. J., et al. Chemogenetic Analysis of Human Protein Methyltransferases. Chem. Biol. Drug Des. 2011 ; 78: 199-210
26. van Nuland R., van Schaik F. M., Simonis M., et al. Nucleosomal DNA Binding Drives the Recognition of H3K36-Methylated Nucleosomes by the PSIP1-PWWP Domain. Epigenetics Chromatin. 2013 ; 6: 12
27. Eidahl J. O., Crowe B. L., North J. A., et al. Structural Basis for High-Affinity Binding of LEDGF PWWP to Mononucleosomes. Nucleic Acids Res. 2013 ; 41: 3924-3936
28. Qiao Q., Li Y., Chen Z., et al. The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation. J. Biol. Chem. 2011 ; 286: 8361-8368
29. Tachiwana H., Kagawa W., Osakabe A., et al. Structural Basis of Instability of the Nucleosome Containing a Testis-Specific Histone Variant, Human H3T. Proc. Natl. Acad. Sci. U. S. A. 2010 ; 107: 10454-10459
30. Kang H. B., Choi Y., Lee J. M., et al. The Histone Methyltransferase, NSD2, Enhances Androgen Receptor-Mediated Transcription. FEBS Lett. 2009 ; 583: 1880-1886
31. An S., Yeo K. J., Jeon Y. H., et al. Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism. J. Biol. Chem. 2011 ; 286: 8369-8374
32. Egelhofer T. A., Minoda A., Klugman S., et al. An Assessment of Histone-Modification Antibody Quality. Nat. Struct. Mol. Biol. 2011 ; 18: 91-93
33. Min J., Feng Q., Li Z., et al. Structure of the Catalytic Domain of Human DOT1L, a Non-SET Domain Nucleosomal Histone Methyltransferase. Cell. 2003 ; 112: 711-723 (Pubitemid 36331782)
34. Albert M., Helin K.. Histone Methyltransferases in Cancer. Semin. Cell Dev. Biol. 2010 ; 21: 209-220
35. Yuan G., Ma B., Yuan W., et al. Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases. J. Biol. Chem. 2013 ; 288: 30832-30842