Enzyme-dependent lysine deprotonation in EZH2 catalysis

Biochemistry

Volumn 52, Issue 39, 2013, Pages 6866-6878

  Kipp, D Randal ^a   Quinn, Christopher M ^a   Fortin, Pascal D ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL MODEL; DIFFERENT SUBSTRATES; EPIGENETIC REGULATION; METHYLTRANSFERASES; PRODUCT SPECIFICITY; S ADENOSYL L METHIONINES; SOLVENT KINETIC ISOTOPE EFFECTS; STEADY STATE RATES;

ALKYLATION; CATALYSIS; DEPROTONATION; ENZYMES; FUNCTIONAL GROUPS; ISOTOPES; METHYLATION; SOLVENTS;

AMINO ACIDS;

HISTONE H3; LYSINE; TRANSCRIPTION FACTOR EZH2;

ARTICLE; CARCINOGENESIS; CATALYSIS; CHEMICAL REACTION; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME BINDING; GAIN OF FUNCTION MUTATION; LOSS OF FUNCTION MUTATION; METHYLATION; PH; PRIORITY JOURNAL; PROTON TRANSPORT; STEADY STATE;

BIOCATALYSIS; HYDROGEN-ION CONCENTRATION; LYSINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; POLYCOMB REPRESSIVE COMPLEX 2; PROTONS;

EID: 84885016465     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400805w     Document Type: Article

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