Enzymatic methyl transfer: Role of an active site residue in generating active site compaction that correlates with catalytic efficiency

Journal of the American Chemical Society

Volumn 133, Issue 43, 2011, Pages 17134-17137

  Zhang, Jianyu ^a,b   Klinman, Judith P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; CATALYTIC EFFICIENCIES; CATECHOL-O-METHYLTRANSFERASE; KINETIC ISOTOPE EFFECTS; LINEAR CORRELATION; METHYL GROUP; METHYL TRANSFERS; POLYMORPHIC VARIANT; PRODUCT DISTRIBUTIONS; S-ADENOSYLMETHIONINE; SIDE-CHAINS; SITE-SPECIFIC; WILD-TYPE PROTEINS;

CARRIER MOBILITY; EFFICIENCY; FUNCTIONAL GROUPS; ISOTOPES; PHENOLS; SULFUR;

COMPACTION;

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHYL GROUP; METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME STRUCTURE; KINETICS; METHYLATION; MUTATION; WILD TYPE;

BIOCATALYSIS; CATALYTIC DOMAIN; CATECHOL O-METHYLTRANSFERASE; CRYSTALLOGRAPHY, X-RAY; DOPAMINE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; S-ADENOSYLMETHIONINE;

EID: 80054999742     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja207467d     Document Type: Article

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