Mediation of donor-acceptor distance in an enzymatic methyl transfer reaction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 26, 2015, Pages 7954-7959

  Zhang, Jianyu ^a,b   Kulik, Heather J ^a,c,d   Martinez, Todd J ^c   Klinman, Judith P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Compaction; COMT; Donor acceptor distance; Methyltransferase; QM MM

Indexed keywords

8 QUINOLINOL; CATECHOL METHYLTRANSFERASE; OXYGEN; S ADENOSYLMETHIONINE; SULFUR; CATECHOL; CATECHOL DERIVATIVE; TYROSINE;

AB INITIO CALCULATION; ARTICLE; CHEMICAL REACTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SUBSTRATE; FLUORESCENCE SPECTROSCOPY; HUMAN; IONIZATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REDUCTION; TIME; CATALYSIS; CHEMISTRY; FLUORESCENCE; GENETICS; METABOLISM; QUANTUM THEORY;

CATALYSIS; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; FLUORESCENCE; HUMANS; QUANTUM THEORY; S-ADENOSYLMETHIONINE; TYROSINE;

EID: 84937949194     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506792112     Document Type: Article

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