In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan

Xenobiotica

Volumn 46, Issue 4, 2016, Pages 325-334

  Matsumoto, Takashi ^a   Kushida, Hirotaka ^a   Maruyama, Takeshi ^a   Nishimura, Hiroaki ^a   Watanabe, Junko ^a   Maemura, Kazuya ^a   Kase, Yoshio ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

Cytochrome P450; Geissoschizine methyl ether; human liver microsomes; metabolism; relative active factor

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GEISSOSCHIZINE METHYL ETHER; INDOLE ALKALOID; KAMPO; UNCLASSIFIED DRUG; YOKUKANSAN; GEISSOSCHIZINE METHYLETHER; HERBACEOUS AGENT; ISOENZYME; RECOMBINANT PROTEIN; YI-GAN SAN;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; IN VITRO STUDY; INTRINSIC CLEARANCE; JAPANESE (PEOPLE); LIVER MICROSOME; MAXIMUM REACTION VELOCITY; METABOLISM; CHEMISTRY; ENZYME SPECIFICITY; FEMALE; LIQUID CHROMATOGRAPHY; MALE; METABOLOME; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; INDOLE ALKALOIDS; ISOENZYMES; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84956921209     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1076585     Document Type: Article

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