The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 972, Issue , 2014, Pages 22-28

  Gai, Yanan ^a,b   Chen, Han ^a   Liu, Wenyuan ^a   Feng, Feng ^a   Xie, Ning ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF BOTANY   (China)

^c Jiangxi Qingfeng Pharmaceutical Corporation   (China)

Author keywords

High performance liquid chromatography; Metabolites; Pharmacokinetics; Quadrupole mass spectrometry; Time of flight mass spectrometry; YiGan San

Indexed keywords

METABOLITES; PHARMACOKINETICS;

LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRIES; PHARMACOKINETIC EVALUATION; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; YIGAN SAN;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

11 HYDROXYHIRSUTEINE; 18 HYDROXYGEISSOSCHIZINE METHYL ETHER; 19 CARBONYLDIHYDROCORYNANTHEINE; 19 CARBONYLHIRSUTINE; AJMALICINE; DRUG METABOLITE; HERBACEOUS AGENT; ISOCORYNOXEINE; LIGUSTILIDE; RHYNCHOPHYLLINE; SENKYUNOLIDE I; UNCLASSIFIED DRUG; YIGAN SAN; BENZOFURAN DERIVATIVE; CORYNOXEINE; INDOLE ALKALOID; RAUWOLFIA ALKALOID; RHYNCOPHYLLINE; YI-GAN SAN;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; HALF LIFE TIME; HETEROSKEDASTICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LINEAR REGRESSION ANALYSIS; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; STATISTICAL ANALYSIS; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRADITIONAL MEDICINE; VALIDATION STUDY; ANIMAL; PROCEDURES; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; BENZOFURANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; INDOLE ALKALOIDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SECOLOGANIN TRYPTAMINE ALKALOIDS; TANDEM MASS SPECTROMETRY;

EID: 84908569097     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.09.033     Document Type: Article

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