Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan

Neuroscience

Volumn 207, Issue , 2012, Pages 124-136

  Nishi, A ^a   Yamaguchi, T ^a   Sekiguchi, K ^a   Imamura, S ^a   Tabuchi, M ^a   Kanno, H ^a   Nakai, Y ^a   Hashimoto, K ^a   Ikarashi, Y ^a   Kase, Y ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

Aggressiveness; Geissoschizine methyl ether; Serotonin1A receptor; Sociality; Uncaria hook; Yokukansan

Indexed keywords

CHINESE DRUG; GEISSOSCHIZINE METHYL ETHER; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SULFUR 35; UNCARA HOOK; UNCLASSIFIED DRUG; YOKUKANSAN;

AGGRESSIVENESS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BINDING ASSAY; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SCREENING; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SOCIAL INTERACTION; SOCIAL ISOLATION;

AGGRESSION; ANIMALS; ANIMALS, OUTBRED STRAINS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CHO CELLS; CRICETINAE; CRICETULUS; INDOLES; MALE; MENTAL DISORDERS; MICE; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN RECEPTOR AGONISTS; SOCIAL BEHAVIOR DISORDERS; UNCARIA;

EID: 84858444053     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.01.037     Document Type: Article

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