Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometry

Biomedical Chromatography

Volumn 27, Issue 12, 2013, Pages 1647-1656

  Kushida, Hirotaka ^a   Fukutake, Miwako ^a   Tabuchi, Masahiro ^a   Katsuhara, Takao ^a   Nishimura, Hiroaki ^a   Ikarashi, Yasushi ^a   Kanitani, Masanao ^a   Kase, Yoshio ^a  

^a TSUMURA AND CO   (Japan)

Author keywords

LC MS MS; Pharmacokinetics; Rat; Uncaria Hook alkaloid; Yokukansan

Indexed keywords

ACETONITRILE; BODY FLUIDS; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PRECIPITATION (CHEMICAL); RATS;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LCMS/MS); METHYL ETHERS; ORAL ADMINISTRATION; RAT PLASMA; RATS BRAIN; UNCARIA HOOK ALKALOID; YOKUKANSAN;

ALKALOIDS;

ALKALOID DERIVATIVE; CORYNOXEINE; GEISSOSCHIZINE METHYL ETHER; HIRSUTEINE; HIRSUTINE; INDOLE ALKALOID; ISOCORYNOXEINE; ISORHYNCHOPHYLLINE; KAMPO; OXINDOLE; OXINDOLE ALKALOID DERIVATIVE; RHYNCHOPHYLLINE; UNCARIA HOOK ALKALOID DERIVATIVE; UNCLASSIFIED DRUG; VINCAMINE; YOKUKANSAN;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; UNCARIA; UNCARIA HOOK;

RATTUS; UNCARIA;

LC/MS/MS; PHARMACOKINETICS; RAT; UNCARIA HOOK ALKALOID; YOKUKANSAN;

ALKALOIDS; ANIMALS; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; INDOLES; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; UNCARIA;

EID: 84887164491     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2974     Document Type: Article

References (23)

1. Corre PL, Dollo G, Chevanne F and Verge RL. Biopharmaceutics and metabolism of yohimbine in humans. European Journal of Pharmaceutical Sciences 1999; 9: 79-84.
2. Fujiwara H, Takayama S, Iwasaki K, Tabuchi M, Yamaguchi T, Sekiguchi K, Ikarashi Y, Kudo Y, Kase Y, Arai H and Yaegashi N. Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice. Neuroscience 2011; 28: 305-313.
3. Ikarashi Y, Iizuka S, Imamura S, Yamaguchi T, Sekiguchi K, Kanno H, Kawakami Z, Yuzurihara M, Kase Y and Takeda S. Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. Biological and Pharmaceutical Bulletin 2009; 32: 1701-1709.
4. Imamura S, Tabuchi M, Kushida H, Nishi A, Kanno H, Yamaguchi T, Sekiguchi K, Ikarashi Y and Kase Y. The blood-brain barrier permeability of geissoschizine methyl ether in Uncaria hook, a galenical constituent of the traditional Japanese medicine Yokukansan. Cellular and Molecular Neurobiology 2011; 31: 787-793.
5. Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H and Sasaki H. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. The Journal of Clinical Psychiatry 2005; 66: 248-252.
6. Kanno H, Sekiguchi K, Yamaguchi T, Terawaki K, Yuzurihara M, Kase Y and Ikarashi Y. Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. Journal of Pharmacy and Pharmacology 2009; 61: 1249-1256.
7. Kawakami Z, Kanno H, Ueki T, Terawaki K, Tabuchi M, Ikarashi Y and Kase Y, Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience 2009; 159: 1397-1407.
8. Kawakami Z, Kanno H, Ikarashi Y and Kase Y. Yokukansan, a kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cells. Journal of Ethnopharmacology 2011; 134: 74-81.
9. Mizukami K, Asada T, Kinoshita T, Tanaka K, Sonohara K, Nakai R, Yamaguchi K, Hanyu H, Kanaya K, Takao T, Okada M, Kudo S, Kotoku H, Iwakiri M, Kurita H, Miyamura T, Kawasaki Y, Omori K, Shiozaki K, Odawara T, Suzuki T, Yamada S, Nakamura Y and Toba K. A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. The International Journal of Neuropsychopharmacology 2009; 12: 191-199.
10. Monji A, Takita M, Samejima T, Takaishi T, Hashimoto K, Matsunaga H, Oda M, Sumida Y, Mizoguchi Y, Kato T, Horikawa H and Kanba S. Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009; 33: 308-311.
11. Nishi A, Yamaguchi T, Sekiguchi K, Imamura S, Tabuchi M, Kanno H, Nakai Y, Hashimoto K, Ikarashi Y and Kase Y. Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin (1A) receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan. Neuroscience 2012; 207: 124-136.
12. Ozaki Y. Pharmacological studies of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult. Nippon Yakurigaku Zasshi 1989; 94: 17-26.
13. Ozaki Y. Vasodilative effects of indole alkaloids obtained from domestic plants, Uncaria rhynchophylla Miq. and Amsonia elliptica Roem. et Schult. Nippon Yakurigaku Zasshi 1990; 95: 47-54.
14. Pengsuparp T, Indra B, Nakagawasai O, Tadano T, Mimaki Y, Sashida Y, Ohizumi Y and Kisara K. Pharmacological studies of geissoschizine methyl ether, isolated from Uncaria sinensis Oliv., in the central nervous system. European Journal of Pharmacology 2001; 425: 211-218.
15. Sekiguchi K, Yamaguchi T, Tabuchi M, Ikarashi Y and Kase Y. Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid beta protein into mice. Phytotherapy Research 2009; 23: 1175-1181.
16. Shimada Y, Goto H, Kogure T, Shibahara N, Sakakibara I, Sasaki H and Terasawa K. Protective effect of phenolic compounds isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. The American Journal of Chinese Medicine 1999; 29: 173-180.
17. Shinno H, Utani E, Okazaki S, Kawamukai T, Yasuda H, Inagaki T, Inami Y and Horiguchi J. Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2007; 31: 1543-1545.
18. Tabuchi M, Yamaguchi T, Iizuka S, Imamura S, Ikarashi Y and Kase Y. Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease. Journal of Ethnopharmacology 2009; 122: 157-162.
19. Tateno M, Ukai W, Ono T, Saito S, Hashimoto E and Saito T. Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008; 32: 1704-1707.
20. Terawaki K, Ikarashi Y, Sekiguchi K, Nakai Y and Kase Y. Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells. Journal of Ethnopharmacology 2010; 127: 306-312.
21. Wang W, Ma CM and Hattori M. Metabolism and pharmacokinetics of rhynchophylline in rats. Biological and Pharmaceutical Bulletin 2010a; 33: 669-676.
22. Wang W, Ma CM and Hattori M. Metabolism of isorhynchophylline in rats detected by LC-MS. Journal of Pharmaceutical Sciences 2010b; 13: 27-37.
23. Yuzurihara M, Ikarashi Y, Goto K, Sakakibara I, Hayakawa T and Sasaki H. Geissoschizine methyl ether, an indole alkaloid extracted from Uncariae Ramulus et Uncus, is a potent vasorelaxant of isolated rat aorta. European Journal of Pharmacology 2002; 31: 183-189.