Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells

Bioscience Reports

Volumn 35, Issue 6, 2015, Pages

  Seo, Hye Sook ^a   Jo, Jae Kyung ^a   Ku, Jin Mo ^a   Choi, Han Seok ^a,b   Choi, Youn Kyung ^a   Woo, Jong Kyu ^c   Kim, Hyo In ^a   Kang, Soo Yeon ^a   Lee, Kang Min ^a   Nam, Koong Won ^a   Park, Namkyu ^a   Jang, Bo Hyoung ^a   Shin, Yong Cheol ^a   Ko, Seong Gyu ^a  

^a Kyung Hee University   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

^c Gachon University College of Medicine   (South Korea)

Author keywords

Apigenin; Apoptosis; Breast cancer; HER2; P53; STAT3

Indexed keywords

APIGENIN; CASPASE; CASPASE 3; CASPASE 8; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GENISTEIN; JANUS KINASE 1; JANUS KINASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; STAT3 PROTEIN; VASCULOTROPIN; ERBB2 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER INHIBITION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE; HIF 1ALPHA GENE; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; UPREGULATION; VEGF GENE; BIOSYNTHESIS; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APIGENIN; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84956915649     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20150165     Document Type: Article

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