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Volumn 68, Issue 2, 2016, Pages 347-358

Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K63-Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6

Author keywords

[No Author keywords available]

Indexed keywords

EPIGALLOCATECHIN GALLATE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; ANTIINFLAMMATORY AGENT; CATECHIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK1 PROTEIN, HUMAN; LYSINE; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEASOME;

EID: 84956810331     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39447     Document Type: Article
Times cited : (52)

References (52)
  • 1
    • 84871778727 scopus 로고    scopus 로고
    • Duality of fibroblast-like synoviocytes in RA: Passive responders and imprinted aggressors
    • Bottini N, Firestein GS., Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol 2013; 9: 24-33.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 24-33
    • Bottini, N.1    Firestein, G.S.2
  • 2
    • 84903523652 scopus 로고    scopus 로고
    • Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
    • Clark JD, Flanagan ME, Telliez JB., Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem 2014; 57: 5023-38.
    • (2014) J Med Chem , vol.57 , pp. 5023-5038
    • Clark, J.D.1    Flanagan, M.E.2    Telliez, J.B.3
  • 3
    • 84864662570 scopus 로고    scopus 로고
    • Kinase inhibition: A new approach to the treatment of rheumatoid arthritis
    • Fox DA., Kinase inhibition: a new approach to the treatment of rheumatoid arthritis. N Engl J Med 2012; 367: 565-7.
    • (2012) N Engl J Med , vol.367 , pp. 565-567
    • Fox, D.A.1
  • 4
    • 84927551421 scopus 로고    scopus 로고
    • Small-molecule therapeutics in rheumatoid arthritis: Scientific rationale, efficacy and safety
    • Meier FM, McInnes IB., Small-molecule therapeutics in rheumatoid arthritis: scientific rationale, efficacy and safety. Best Pract Clin Res Rheumatol 2014; 28: 605-24.
    • (2014) Best Pract Clin Res Rheumatol , vol.28 , pp. 605-624
    • Meier, F.M.1    McInnes, I.B.2
  • 5
    • 84866731086 scopus 로고    scopus 로고
    • Targeting of TAK1 in inflammatory disorders and cancer
    • Sakurai H., Targeting of TAK1 in inflammatory disorders and cancer. Trends Pharmacol Sci 2012; 33: 522-30.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 522-530
    • Sakurai, H.1
  • 7
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
    • Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 1995; 270: 2008-11.
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1    Shirakabe, K.2    Shibuya, H.3    Irie, K.4    Oishi, I.5    Ueno, N.6
  • 8
    • 84892839044 scopus 로고    scopus 로고
    • Treating inflammation by blocking interleukin-1 in humans
    • Dinarello CA, van der Meer JW., Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 2013; 25: 469-84.
    • (2013) Semin Immunol , vol.25 , pp. 469-484
    • Dinarello, C.A.1    Van Der Meer, J.W.2
  • 9
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, et al., Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 2000; 191: 313-20.
    • (2000) J Exp Med , vol.191 , pp. 313-320
    • Horai, R.1    Saijo, S.2    Tanioka, H.3    Nakae, S.4    Sudo, K.5    Okahara, A.6
  • 10
    • 58349113392 scopus 로고    scopus 로고
    • Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: Meta-analyses of randomised placebo-controlled trials
    • Salliot C, Dougados M, Gossec L., Risk of serious infections during rituximab, abatacept and anakinra treatments for rheumatoid arthritis: meta-analyses of randomised placebo-controlled trials. Ann Rheum Dis 2009; 68: 25-32.
    • (2009) Ann Rheum Dis , vol.68 , pp. 25-32
    • Salliot, C.1    Dougados, M.2    Gossec, L.3
  • 11
    • 1542313935 scopus 로고    scopus 로고
    • Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor α blockade
    • Buch MH, Bingham SJ, Seto Y, McGonagle D, Bejarano V, White J, et al., Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor α blockade. Arthritis Rheum 2004; 50: 725-8.
    • (2004) Arthritis Rheum , vol.50 , pp. 725-728
    • Buch, M.H.1    Bingham, S.J.2    Seto, Y.3    McGonagle, D.4    Bejarano, V.5    White, J.6
  • 12
    • 84939999689 scopus 로고    scopus 로고
    • Interleukin-1 receptor associated kinase inhibitors: Potential therapeutic agents for inflammatory- and immune-related disorders
    • Bahia MS, Kaur M, Silakari P, Silakari O., Interleukin-1 receptor associated kinase inhibitors: potential therapeutic agents for inflammatory- and immune-related disorders. Cell Signal 2015; 27: 1039-55.
    • (2015) Cell Signal , vol.27 , pp. 1039-1055
    • Bahia, M.S.1    Kaur, M.2    Silakari, P.3    Silakari, O.4
  • 13
    • 84868702961 scopus 로고    scopus 로고
    • β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation
    • Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, et al., β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation. Mol Cell Biol 2012; 32: 3990-4000.
    • (2012) Mol Cell Biol , vol.32 , pp. 3990-4000
    • Cui, W.1    Xiao, N.2    Xiao, H.3    Zhou, H.4    Yu, M.5    Gu, J.6
  • 14
    • 84875219876 scopus 로고    scopus 로고
    • IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production
    • Zhou H, Yu M, Fukuda K, Im J, Yao P, Cui W, et al., IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. EMBO J 2013; 32: 583-96.
    • (2013) EMBO J , vol.32 , pp. 583-596
    • Zhou, H.1    Yu, M.2    Fukuda, K.3    Im, J.4    Yao, P.5    Cui, W.6
  • 15
    • 53349164136 scopus 로고    scopus 로고
    • The type i TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
    • Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, et al., The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 2008; 10: 1199-207.
    • (2008) Nat Cell Biol , vol.10 , pp. 1199-1207
    • Sorrentino, A.1    Thakur, N.2    Grimsby, S.3    Marcusson, A.4    Von Bulow, V.5    Schuster, N.6
  • 16
    • 84863338304 scopus 로고    scopus 로고
    • Ubiquitination in signaling to and activation of IKK
    • Chen ZJ., Ubiquitination in signaling to and activation of IKK. Immunol Rev 2012; 246: 95-106.
    • (2012) Immunol Rev , vol.246 , pp. 95-106
    • Chen, Z.J.1
  • 17
    • 55749088803 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production
    • Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, et al., Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A 2008; 105: 14692-7.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14692-14697
    • Ahmed, S.1    Marotte, H.2    Kwan, K.3    Ruth, J.H.4    Campbell, P.L.5    Rabquer, B.J.6
  • 18
    • 33747015294 scopus 로고    scopus 로고
    • Regulation of interleukin-1β-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts
    • Ahmed S, Pakozdi A, Koch AE., Regulation of interleukin-1β-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2006; 54: 2393-401.
    • (2006) Arthritis Rheum , vol.54 , pp. 2393-2401
    • Ahmed, S.1    Pakozdi, A.2    Koch, A.E.3
  • 19
    • 66049161848 scopus 로고    scopus 로고
    • Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α-induced apoptosis
    • Ahmed S, Silverman MD, Marotte H, Kwan K, Matuszczak N, Koch AE., Down-regulation of myeloid cell leukemia 1 by epigallocatechin-3-gallate sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor α-induced apoptosis. Arthritis Rheum 2009; 60: 1282-93.
    • (2009) Arthritis Rheum , vol.60 , pp. 1282-1293
    • Ahmed, S.1    Silverman, M.D.2    Marotte, H.3    Kwan, K.4    Matuszczak, N.5    Koch, A.E.6
  • 20
    • 0013909023 scopus 로고
    • Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man
    • Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE., Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep 1966; 50: 219-44.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 219-244
    • Freireich, E.J.1    Gehan, E.A.2    Rall, D.P.3    Schmidt, L.H.4    Skipper, H.E.5
  • 21
    • 0033580466 scopus 로고    scopus 로고
    • The kinase TAK1 can activate the NIK-I κb as well as the MAP kinase cascade in the IL-1 signalling pathway
    • Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K., The kinase TAK1 can activate the NIK-I κB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 1999; 398: 252-6.
    • (1999) Nature , vol.398 , pp. 252-256
    • Ninomiya-Tsuji, J.1    Kishimoto, K.2    Hiyama, A.3    Inoue, J.4    Cao, Z.5    Matsumoto, K.6
  • 22
    • 0033036063 scopus 로고    scopus 로고
    • Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
    • Knop J, Martin MU., Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. FEBS Lett 1999; 448: 81-5.
    • (1999) FEBS Lett , vol.448 , pp. 81-85
    • Knop, J.1    Martin, M.U.2
  • 23
    • 0033002994 scopus 로고    scopus 로고
    • Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
    • Li X, Commane M, Burns C, Vithalani K, Cao Z, Stark GR., Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol Cell Biol 1999; 19: 4643-52.
    • (1999) Mol Cell Biol , vol.19 , pp. 4643-4652
    • Li, X.1    Commane, M.2    Burns, C.3    Vithalani, K.4    Cao, Z.5    Stark, G.R.6
  • 24
    • 0033560731 scopus 로고    scopus 로고
    • Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κ
    • Maschera B, Ray K, Burns K, Volpe F., Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κ B Biochem J 1999; 339: 227-31.
    • (1999) B Biochem J , vol.339 , pp. 227-231
    • Maschera, B.1    Ray, K.2    Burns, K.3    Volpe, F.4
  • 25
    • 84880847105 scopus 로고    scopus 로고
    • Cell type-specific function of TAK1 in innate immune signaling
    • Ajibade AA, Wang HY, Wang RF., Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol 2013; 34: 307-16.
    • (2013) Trends Immunol , vol.34 , pp. 307-316
    • Ajibade, A.A.1    Wang, H.Y.2    Wang, R.F.3
  • 26
    • 14844295421 scopus 로고    scopus 로고
    • Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-β-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2
    • Singhirunnusorn P, Suzuki S, Kawasaki N, Saiki I, Sakurai H., Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-β-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 2005; 280: 7359-68.
    • (2005) J Biol Chem , vol.280 , pp. 7359-7368
    • Singhirunnusorn, P.1    Suzuki, S.2    Kawasaki, N.3    Saiki, I.4    Sakurai, H.5
  • 27
    • 54049157903 scopus 로고    scopus 로고
    • Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFκB and AP-1 activation as well as IL-6 gene expression
    • Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, et al., Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFκB and AP-1 activation as well as IL-6 gene expression. J Biol Chem 2008; 283: 24497-505.
    • (2008) J Biol Chem , vol.283 , pp. 24497-24505
    • Yu, Y.1    Ge, N.2    Xie, M.3    Sun, W.4    Burlingame, S.5    Pass, A.K.6
  • 28
    • 84921417645 scopus 로고    scopus 로고
    • TAK1 selective inhibition: State of the art and future opportunities
    • Kilty I, Jones LH., TAK1 selective inhibition: state of the art and future opportunities. Future Med Chem 2015; 7: 23-33.
    • (2015) Future Med Chem , vol.7 , pp. 23-33
    • Kilty, I.1    Jones, L.H.2
  • 29
    • 34248570795 scopus 로고    scopus 로고
    • Ubiquitin-mediated activation of TAK1 and IKK
    • Adhikari A, Xu M, Chen ZJ., Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 2007; 26: 3214-26.
    • (2007) Oncogene , vol.26 , pp. 3214-3226
    • Adhikari, A.1    Xu, M.2    Chen, Z.J.3
  • 30
    • 68049084674 scopus 로고    scopus 로고
    • Breaking the chains: Structure and function of the deubiquitinases
    • Komander D, Clague MJ, Urbe S., Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 2009; 10: 550-63.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 550-563
    • Komander, D.1    Clague, M.J.2    Urbe, S.3
  • 31
    • 33947506493 scopus 로고    scopus 로고
    • Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation
    • Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG., Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation. J Biol Chem 2007; 282: 4102-12.
    • (2007) J Biol Chem , vol.282 , pp. 4102-4112
    • Lamothe, B.1    Besse, A.2    Campos, A.D.3    Webster, W.K.4    Wu, H.5    Darnay, B.G.6
  • 32
    • 84875208605 scopus 로고    scopus 로고
    • Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol
    • Wu J, Powell F, Larsen NA, Lai Z, Byth KF, Read J, et al., Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol. ACS Chem Biol 2013; 8: 643-50.
    • (2013) ACS Chem Biol , vol.8 , pp. 643-650
    • Wu, J.1    Powell, F.2    Larsen, N.A.3    Lai, Z.4    Byth, K.F.5    Read, J.6
  • 33
    • 0042334847 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon e in healthy individuals
    • Chow HH, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, et al., Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res 2003; 9: 3312-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 3312-3319
    • Chow, H.H.1    Cai, Y.2    Hakim, I.A.3    Crowell, J.A.4    Shahi, F.5    Brooks, C.A.6
  • 34
    • 84898655870 scopus 로고    scopus 로고
    • Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner
    • Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, et al., Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner. J Biol Chem 2014; 289: 10865-75.
    • (2014) J Biol Chem , vol.289 , pp. 10865-10875
    • Cushing, L.1    Stochaj, W.2    Siegel, M.3    Czerwinski, R.4    Dower, K.5    Wright, Q.6
  • 35
    • 62749099990 scopus 로고    scopus 로고
    • The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells
    • Song KW, Talamas FX, Suttmann RT, Olson PS, Barnett JW, Lee SW, et al., The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells. Mol Immunol 2009; 46: 1458-66.
    • (2009) Mol Immunol , vol.46 , pp. 1458-1466
    • Song, K.W.1    Talamas, F.X.2    Suttmann, R.T.3    Olson, P.S.4    Barnett, J.W.5    Lee, S.W.6
  • 36
    • 85030092658 scopus 로고    scopus 로고
    • Multi-omic landscape of rheumatoid arthritis: Re-evaluation of drug adverse effects
    • Tieri P, Zhou X, Zhu L, Nardini C., Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects. Front Cell Dev Biol 2014; 2: 59.
    • (2014) Front Cell Dev Biol , vol.2 , pp. 59
    • Tieri, P.1    Zhou, X.2    Zhu, L.3    Nardini, C.4
  • 37
    • 84859024338 scopus 로고    scopus 로고
    • Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts: From the point of view of mouse genomics
    • Cao Y, Jiao Y, Wang L, Huang Y, Postlethwaite A, Stuart J, et al., Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts: from the point of view of mouse genomics. Int Immunopharmacol 2012; 13: 28-36.
    • (2012) Int Immunopharmacol , vol.13 , pp. 28-36
    • Cao, Y.1    Jiao, Y.2    Wang, L.3    Huang, Y.4    Postlethwaite, A.5    Stuart, J.6
  • 38
    • 34347392053 scopus 로고    scopus 로고
    • Regulation of the JNK pathway by TGF-β activated kinase 1 in rheumatoid arthritis synoviocytes
    • Hammaker DR, Boyle DL, Inoue T, Firestein GS., Regulation of the JNK pathway by TGF-β activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther 2007; 9: R57.
    • (2007) Arthritis Res Ther , vol.9 , pp. R57
    • Hammaker, D.R.1    Boyle, D.L.2    Inoue, T.3    Firestein, G.S.4
  • 39
    • 78149342873 scopus 로고    scopus 로고
    • In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
    • Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, et al., In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood 2010; 116: 3505-16.
    • (2010) Blood , vol.116 , pp. 3505-3516
    • Courties, G.1    Seiffart, V.2    Presumey, J.3    Escriou, V.4    Scherman, D.5    Zwerina, J.6
  • 41
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-κB pathway
    • Chen ZJ., Ubiquitin signalling in the NF-κB pathway. Nat Cell Biol 2005; 7: 758-65.
    • (2005) Nat Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 42
    • 84875231510 scopus 로고    scopus 로고
    • Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?
    • Nathan JA, Kim HT, Ting L, Gygi SP, Goldberg AL., Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J 2013; 32: 552-65.
    • (2013) EMBO J , vol.32 , pp. 552-565
    • Nathan, J.A.1    Kim, H.T.2    Ting, L.3    Gygi, S.P.4    Goldberg, A.L.5
  • 43
    • 1642538979 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1β-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes
    • Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM., Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1β-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol Exp Ther 2004; 308: 767-73.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 767-773
    • Ahmed, S.1    Wang, N.2    Lalonde, M.3    Goldberg, V.M.4    Haqqi, T.M.5
  • 44
    • 33748751685 scopus 로고    scopus 로고
    • Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB
    • Hafeez BB, Ahmed S, Wang N, Gupta S, Zhang A, Haqqi TM., Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB. Toxicol Appl Pharmacol 2006; 216: 11-9.
    • (2006) Toxicol Appl Pharmacol , vol.216 , pp. 11-19
    • Hafeez, B.B.1    Ahmed, S.2    Wang, N.3    Gupta, S.4    Zhang, A.5    Haqqi, T.M.6
  • 45
    • 0036676819 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: Suppression of nuclear factor κb activation by degradation of the inhibitor of nuclear factor κb
    • Singh R, Ahmed S, Islam N, Goldberg VM, Haqqi TM., Epigallocatechin-3-gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor κB. Arthritis Rheum 2002; 46: 2079-86.
    • (2002) Arthritis Rheum , vol.46 , pp. 2079-2086
    • Singh, R.1    Ahmed, S.2    Islam, N.3    Goldberg, V.M.4    Haqqi, T.M.5
  • 46
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L, Wang C, Spencer E, Yang L, Braun A, You J, et al., Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000; 103: 351-61.
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3    Yang, L.4    Braun, A.5    You, J.6
  • 47
    • 0242720415 scopus 로고    scopus 로고
    • TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology
    • Wu H, Arron JR., TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 2003; 25: 1096-105.
    • (2003) Bioessays , vol.25 , pp. 1096-1105
    • Wu, H.1    Arron, J.R.2
  • 48
    • 77949571175 scopus 로고    scopus 로고
    • The risk of infections with biologic therapies for rheumatoid arthritis
    • Furst DE., The risk of infections with biologic therapies for rheumatoid arthritis. Semin Arthritis Rheum 2010; 39: 327-46.
    • (2010) Semin Arthritis Rheum , vol.39 , pp. 327-346
    • Furst, D.E.1
  • 49
    • 1942435955 scopus 로고    scopus 로고
    • Safety of tumour necrosis factor-α antagonists
    • Khanna D, McMahon M, Furst DE., Safety of tumour necrosis factor-α antagonists. Drug Saf 2004; 27: 307-24.
    • (2004) Drug Saf , vol.27 , pp. 307-324
    • Khanna, D.1    McMahon, M.2    Furst, D.E.3
  • 52
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok B, Firestein GS., Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-55.
    • (2010) Immunol Rev , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.