Anakinra as an interleukin 1 receptor antagonist, complicated genetics and molecular impacts- from the point of view of mouse genomics

International Immunopharmacology

Volumn 13, Issue 1, 2012, Pages 28-36

  Cao, Yanhong ^a,b   Jiao, Yan ^b   Wang, Lishi ^b   Huang, Yue ^b   Postlethwaite, Arnold ^b,c   Stuart, John ^b,c   Kang, Andy ^b,c   Williams, Robert W ^b   Gu, Weikuan ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Anakinra; Arthritis; Expression; Genomic background; IL 1 receptor antagonist; Inflammation

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ADULT ONSET STILL DISEASE; AMINO ACID SEQUENCE; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; ARTICLE; BRAIN; CEREBELLUM; CINCA SYNDROME; CORPUS STRIATUM; CORRELATION ANALYSIS; ENVIRONMENTAL FACTOR; EYE; FAMILIAL MEDITERRANEAN FEVER; GENE CONTROL; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE PROBE; GENETICS; GENOMICS; GOUT; HIPPOCAMPUS; HUMAN; JOINT EFFUSION; JUVENILE RHEUMATOID ARTHRITIS; KIDNEY; LUNG; METABOLISM; MEVALONATE KINASE DEFICIENCY; MUCKLE WELLS SYNDROME; NONHUMAN; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SCHNITZLER SYNDROME; SPLEEN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PERIODIC SYNDROME;

EID: 84859024338     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.02.014     Document Type: Review

References (49)

1. D.B. Carter, M.R. Deibel Jr., C.J. Dunn, C.S. Tomich, A.L. Laborde, and J.L. Slightom Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein Nature 344 1990 633 638
2. M.H. Schiff Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis Ann Rheum Dis 59 Suppl. 1 2000 i103 i108 Review
3. A.I. Blakemore, J.K. Tarlow, M.J. Cork, C. Gordon, P. Emery, and G.W. Duff Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus Arthritis Rheum 37 1994 1380 1385
4. J.C. Mansfield, H. Holden, J.K. Tarlow, F.S. Di Giovine, T.L. McDowell, and A.G. Wilson Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist Gastroenterology 106 1994 637 642
5. J.K. Tarlow, F.E. Clay, M.J. Cork, A.I. Blakemore, A.J. McDonagh, and A.G. Messenger Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene J Invest Dermatol 103 1994 387 390
6. H.M. Schrijver, J.B. Crusius, B.M. Uitdehaag, M.A. García González, P.J. Kostense, and C.H. Polman Association of interleukin-1beta and interleukin-1 receptor antagonist genes with disease severity in MS Neurology 52 1999 595 599
7. A.I. Blakemore, A. Cox, A.M. Gonzalez, J.K. Maskil, M.E. Hughes, and R.M. Wilson Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus Hum Genet 97 1996 369 374
8. L. Strandberg, M. Lorentzon, A. Hellqvist, S. Nilsson, V. Wallenius, and C. Ohlsson Interleukin-1 system gene polymorphisms are associated with fat mass in young men J Clin Endocrinol Metab 91 2006 2749 2754 Epub 2006 Apr 24
9. I. Aksentijevich, S.L. Masters, P.J. Ferguson, P. Dancey, J. Frenkel, and A. van Royen-Kerkhoff An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist N Engl J Med 360 2009 2426 2437
10. S. Reddy, S. Jia, R. Geoffrey, R. Lorier, M. Suchi, and U. Broeckel An autoinflammatory disease due to homozygous deletion of the IL1RN locus N Engl J Med 360 2009 2438 2444
11. H. Baradaran-Rahimi, M. Radvar, H.R. Arab, J. Tavakol-Afshari, and A.R. Ebadian Association of interleukin-1 receptor antagonist gene polymorphisms with generalized aggressive periodontitis in an Iranian population J Periodontol 81 2010 1342 1346
12. Susanne Schulz, Jamal M. Stein, Wolfgang Altermann, Jana Klapproth, Uta Zimmermann, and Yvonne Reichert Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis Hum Immunol 72 2011 940 946 Epub 2011 Jun 1
13. L. Naumann, E. Feist, A. Natusch, S. Langen, A. Krause, and F. Buttgereit IL1-receptor antagonist anakinra provides long-lasting efficacy in the treatment of refractory adult-onset Still's disease Ann Rheum Dis 69 2010 466 467
14. A. Arman, O. Soylu, A. Yildirim, A. Furman, N. Ercelen, and H. Aydogan Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease Arq Bras Cardiol 91 2008 293 298
15. M. Xu, and L. He Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population Schizophr Res 120 2010 131 142 Epub 2010 Mar 26
16. E.M. El-Omar, M. Carrington, W.H. Chow, K.E. McColl, J.H. Bream, and H.A. Young Interleukin-1 polymorphisms associated with increased risk of gastric cancer Nature 404 6776 2000 398 402
17. Erratum in: Nature 412 6842 2001 99
18. B. Peleteiro, N. Lunet, C. Carrilho, C. Durães, J.C. Machado, and C. La Vecchia Association between cytokine gene polymorphisms and gastric precancerous lesions: systematic review and meta-analysis Cancer Epidemiol Biomarkers Prev 19 2010 762 776
19. E.J. Bodar, L.M. Kuijk, J.P. Drenth, J.W. van der Meer, A. Simon, and J. Frenkel On-demand anakinra treatment is effective in mevalonate kinase deficiency Ann Rheum Dis 70 2011 2155 2158 Epub 2011 Aug 21
20. K.A. Sikora, and A.A. Grom Update on the pathogenesis and treatment of systemic idiopathic arthritis Curr Opin Pediatr 23 6 2010 640 646
21. P.A. Nigrovic, M. Mannion, F.H. Prince, A. Zeft, C.E. Rabinovich, and M.A. van Rossum Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series Arthritis Rheum 63 2011 545 555 10.1002/art.30128
22. N. Bruck, M. Suttorp, M. Kabus, G. Heubner, M. Gahr, and F. Pessler Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids J Clin Rheumatol 17 2011 23 27
23. H. Tsukamoto, N. Ueda, and T. Horiuchi Progress in classification and treatment for TNF receptor-associated periodic syndrome Nihon Rinsho Meneki Gakkai Kaishi 34 5 2011 361 368
24. A.P. Tran, and J. Edelman Interleukin-1 inhibition by anakinra in refractory chronic tophaceous gout Int J Rheum Dis 14 2011 e33 e37 10.1111/j.1756-185X.2011.01629
25. M.A. Vandenhende, F. Bentaberry, P. Morlat, and F. Bonnet Anakinra: an effective treatment in the Schnitzler syndrome Joint Bone Spine 78 6 2011 636 637
26. C. Terrada, B. Neven, N. Boddaert, E.H. Souied, A.M. Prieur, and P. Quartier Ocular modifications in a young girl with cryopyrin-associated periodic syndromes responding to interleukin-1 receptor antagonist anakinra J Ophthalmic Inflamm Infect 1 2011 133 136 Epub 2011 Apr 9
27. N. Kluger, D. Gil-Bistes, B. Guillot, and D. Bessis Efficacy of anti-interleukin-1 receptor antagonist anakinra (Kineret®) in a case of refractory Sweet's syndrome Dermatology 222 2011 123 127 Epub 2011 Apr 5
28. J.B. Kuemmerle-Deschner, P.N. Tyrrell, I. Koetter, H. Wittkowski, A. Bialkowski, and N. Tzaribachev Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome Arthritis Rheum 63 2011 840 849 10.1002/art.30149
29. C.A. Brown, A.P. Toth, and B. Magnussen Clinical benefits of intra-articular anakinra for arthrofibrosis Orthopedics 33 2010 877 10.3928/01477447-20101021-09
30. K. Stankovic Stojanovic, Y. Delmas, P. Ureña Torres, J. Peltier, G. Pelle, and I. Jéru Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure Nephrol Dial Transplant 29 2011 [Epub ahead of print]
31. H. El-Osta, F. Janku, and R. Kurzrock Successful treatment of Castleman's disease with interleukin-1 receptor antagonist (Anakinra) Mol Cancer Ther 9 2010 1485 1488 Epub 2010 May 25
32. C. Brown, A. Toth, and R. Magnussen Clinical benefits of intra-articular anakinra for persistent knee effusion J Knee Surg 24 2011 61 65
33. D. Rigante, A. Leone, R. Marrocco, M.E. Laino, and A. Stabile Long-term response after 6-year treatment with anakinra and onset of focal bone erosion in neonatal-onset multisystem inflammatory disease (NOMID/CINCA) Rheumatol Int 31 2011 1661 1664 Epub 2011 Jan 15
34. Z. Lin, J.P. Hegarty, T. Lin, B. Ostrov, Y. Wang, and W. Yu Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene Inflamm Bowel Dis 17 2011 E41 E42 10.1002/ibd.21684 Epub 2011 Mar 15
35. M. Mahamid, K. Paz, M. Reuven, and R. Safadi Hepatotoxicity due to tocilizumab and anakinra in rheumatoid arthritis: two case reports Int J Gen Med 4 2011 657 660 Epub 2011 Sep 7
36. E.J. van Asseldonk, R. Stienstra, T.B. Koenen, L.A. Joosten, M.G. Netea, and C.J. Tack Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study J Clin Endocrinol Metab 96 2011 2119 2126 Epub 2011 Apr 20
37. N.M. Luheshi, N.J. Rothwell, and D. Brough Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy Br J Pharmacol 157 8 2009 1318 1329
38. E.J. Chesler, L. Lu, J. Wang, R.W. Williams, and K.F. Manly WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior Nat Neurosci 7 2004 485 486
39. J.L. Peirce, L. Lu, J. Gu, L.M. Silver, and R.W. Williams A new set of BXD recombinant inbred lines from advanced intercross populations in mice BMC Genet 29 2004 5 7
40. James F. Crow Haldane, Bailey, Taylor and recombinant-inbred lines Genetics 176 2007 729 732
41. H. Cao, J. Wu, S. Lam, R. Duan, C. Newnham, and R.S. Molday Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8-implications in the pathogenesis of RP PLoS One 6 1 2011 e15860
42. B. Linder, H. Dill, A. Hirmer, J. Brocher, G.P. Lee, and S. Mathavan Systemic splicing factor deficiency causes tissue-specific defects: a zebrafish model for retinitis pigmentosa Hum Mol Genet 20 2 2011 368 377 Epub 2010 Nov 3
43. L.F. de Navas, H. Reed, M. Akam, R. Barrio, C.R. Alonso, and E. Sánchez-Herrero Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development Development 138 1 2011 107 116 Epub 2010 Nov 29
44. I. Evans, S.K. Dower, S.E. Francis, D.C. Crossman, and H.L. Wilson Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway Cytokine 33 5 2006 274 280 Epub 2006 Mar 27
45. R. Horai, S. Saijo, H. Tanioka, S. Nakae, K. Sudo, and A. Okahara Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice J Exp Med 191 2000 313 320
46. F. Zhou, X. He, Y. Iwakura, R. Horai, and J.M. Stuart Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background Arthritis Rheum 52 2005 3731 3738
47. K. Isoda, T. Matsuki, H. Kondo, Y. Iwakura, and F. Ohsuzu Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice Arterioscler Thromb Vasc Biol 30 2010 708 715 Epub 2010 Jan 28
48. K. Isoda, M. Kitagaki, T. Niida, H. Kondo, O. Matsubara, and M. Kikuchi Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice Am J Pathol Jan. 11 2012 [Epub ahead of print]
49. G. Wolf, D. Livshits, B. Beilin, R. Yirmiya, and Y. Shavit Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice Brain Behav Immun 22 7 2008 1072 1077 Epub 2008 Apr 28