Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-κB

Toxicology and Applied Pharmacology

Volumn 216, Issue 1, 2006, Pages 11-19

  Hafeez, Bilal Bin ^a   Ahmed, Salahuddin ^a   Wang, Naizhen ^a   Gupta, Sanjay ^a   Zhang, Ailin ^a   Haqqi, Tariq M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspases; Green tea; Nuclear factor B; Osteosarcoma

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE INHIBITOR; CELL NUCLEUS DNA; GREEN TEA EXTRACT; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N ACETYLASPARTYLGLUTAMYLVALYLASPARTIC ACID ALDEHYDE; N BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; POLYPHENOL DERIVATIVE; PROTEIN BAX; PROTEIN BNIP3; PROTEIN P50; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLAVONOIDS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; IMMUNOBLOTTING; NF-KAPPA B P50 SUBUNIT; OLIGOPEPTIDES; OSTEOSARCOMA; PHENOLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; TEA; TRANSCRIPTION FACTOR RELA;

EID: 33748751685     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.03.013     Document Type: Article

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