Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence Annotation

PLoS Computational Biology

Volumn 12, Issue 1, 2016, Pages

  Ralph, Duncan K ^a   Matsen, Frederick A ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELL MEMBRANES; GENES; PROBABILITY DISTRIBUTIONS;

B-CELLS RECEPTORS; HIDDEN-MARKOV MODELS; HIGH-THROUGHPUT; MODEL TRANSITION; NEUTRALIZING ANTIBODIES; PARAMETRIC DISTRIBUTIONS; SEQUENCE ANALYSIS; SIMPLE++; SOMATIC HYPERMUTATION; TEMPLATED;

HIDDEN MARKOV MODELS;

B LYMPHOCYTE RECEPTOR; EXONUCLEASE;

ALLELE; ARTICLE; COMPUTER PROGRAM; GENE INSERTION; GENE MUTATION; GENE REARRANGEMENT; HIDDEN MARKOV MODEL; HUMAN; MATHEMATICAL COMPUTING; MATHEMATICAL PARAMETERS; MAXIMUM LIKELIHOOD METHOD; MOLECULAR GENETICS; SEQUENCE ANALYSIS; SIMULATION; VDJ EXON; VDJ RECOMBINATION; BIOLOGICAL MODEL; BIOLOGY; COMPUTER SIMULATION; DNA SEQUENCE; GENETIC DATABASE; GENETICS; PROCEDURES;

COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DATABASES, GENETIC; GENE REARRANGEMENT, B-LYMPHOCYTE; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE ANNOTATION; SEQUENCE ANALYSIS, DNA; VDJ EXONS;

EID: 84956797821     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004409     Document Type: Article

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