Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 8, 2015, Pages E862-E870

  Gadala Maria, Daniel ^a   Yaari, Gur ^b,c   Uduman, Mohamed ^b   Kleinstein, Steven H ^a,b,c  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BAR ILAN UNIVERSITY   (Israel)

Author keywords

Adaptive immunity; B cell repertoire; Next generation sequencing; Somatic hypermutation; Variable gene segment

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

ADAPTIVE IMMUNITY; ALLELE; ARTICLE; B LYMPHOCYTE; GENE FREQUENCY; GENOTYPE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; NEXT GENERATION SEQUENCING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; AUTOMATION; COMPUTER PROGRAM; GENE REARRANGEMENT; GENETIC DATABASE; GENETIC POLYMORPHISM; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOGLOBULIN GENE; METABOLISM; MUTATION; MUTATION RATE; PROCEDURES; VDJ RECOMBINATION;

ALLELES; AUTOMATION; B-LYMPHOCYTES; BASE SEQUENCE; DATABASES, GENETIC; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; GENOTYPE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MUTATION; MUTATION RATE; POLYMORPHISM, GENETIC; SOFTWARE; V(D)J RECOMBINATION;

EID: 84923657453     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417683112     Document Type: Article

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