Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli

PLoS Computational Biology

Volumn 12, Issue 1, 2016, Pages

  Oberhardt, Matthew A ^a,b   Zarecki, Raphy ^a   Reshef, Leah ^a   Xia, Fangfang ^c   Duran Frigola, Miquel ^d   Schreiber, Rachel ^a   Henry, Christopher S ^c   Ben Tal, Nir ^a   Dwyer, Daniel J ^e   Gophna, Uri ^a   Ruppin, Eytan ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b University of Maryland ^*  (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^e Bldg 142   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; FORECASTING; GENE EXPRESSION; METABOLISM;

ALTERNATIVE ROUTES; E. COLI; METABOLIC GENES; MULTICOPY SUPPRESSION; OVEREXPRESSIONS; PHOSPHATE PRODUCTION; PROMISCUOUS ACTIVITY; PSI-BLAST; PYRIDOXAL 5' PHOSPHATES; TARGET GENES;

ENZYMES;

PYRIDOXAL 5 PHOSPHATE; ESCHERICHIA COLI PROTEIN; OXIDOREDUCTASE; PDXB PROTEIN, E COLI; THIG PROTEIN, E COLI;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PROMISCUITY; ESCHERICHIA COLI; GENE; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; GENOME SCALE METABOLIC MODEL; INVESTIGATIVE PROCEDURES; NONHUMAN; PDXB GENE; PREDICTION; PREDICTOR VARIABLE; PROMISCUITY PREDICTOR METHOD; THIG GENE; VALIDATION STUDY; VITAMIN METABOLISM; BIOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR MODEL; PROCEDURES;

CARBOHYDRATE DEHYDROGENASES; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; PYRIDOXAL PHOSPHATE;

EID: 84956745187     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004705     Document Type: Article

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