Network-level architecture and the evolutionary potential of underground metabolism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 32, 2014, Pages 11762-11767

  Notebaart, Richard A ^a   Szappanos, Balázs ^b   Kintses, Bálint ^b   Pál, Ferenc ^b   Györkei, Ádám ^b   Bogos, Balázs ^b   Lázár, Viktória ^b   Spohn, Réka ^b   Csörgö, Bálint ^b   Wagner, Allon ^c   Ruppin, Eytan ^c   Pál, Csaba ^b   Papp, Balázs ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Enzyme promiscuity; Evolutionary innovation; Molecular evolution; Network evolution; Phenotype microarray

Indexed keywords

CARBON;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL METABOLISM; CARBON SOURCE; COMPUTER MODEL; ENVIRONMENT; ESCHERICHIA COLI; EVOLUTIONARY ADAPTATION; GAIN OF FUNCTION MUTATION; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ENZYME PROMISCUITY; EVOLUTIONARY INNOVATION; MOLECULAR EVOLUTION; NETWORK EVOLUTION; PHENOTYPE MICROARRAY;

ADAPTATION, PHYSIOLOGICAL; BIOLOGICAL EVOLUTION; COMPUTER SIMULATION; ENZYMES; ESCHERICHIA COLI K12; ESCHERICHIA COLI PROTEINS; GENOME, BACTERIAL; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; PHENOTYPE;

EID: 84905969902     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406102111     Document Type: Article

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