메뉴 건너뛰기




Volumn 13, Issue 1, 2012, Pages

An in silico platform for the design of heterologous pathways in nonnative metabolite production

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR GROWTH; CORYNEBACTERIUM GLUTAMICUM; FLUX BALANCE ANALYSIS; IN-SILICO; INDUSTRIAL PROCESSS; METABOLIC NETWORK; METABOLIC PATHWAYS; METABOLIC REACTIONS; METABOLITE PRODUCTION; PRODUCTION OF;

EID: 84860819691     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-13-93     Document Type: Article
Times cited : (20)

References (67)
  • 1
    • 83255174106 scopus 로고    scopus 로고
    • Relative potential of biosynthetic pathways for biofuels and bio-based products
    • 10.1038/nbt.2055, 22158355
    • Dugar D, Stephanopoulos G. Relative potential of biosynthetic pathways for biofuels and bio-based products. Nat Biotechnol 2011, 29:1074-1078. 10.1038/nbt.2055, 22158355.
    • (2011) Nat Biotechnol , vol.29 , pp. 1074-1078
    • Dugar, D.1    Stephanopoulos, G.2
  • 2
    • 57049098094 scopus 로고    scopus 로고
    • Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
    • 10.1016/j.copbio.2008.10.014, 18996194
    • Lee SK, Chou H, Ham TS, Lee TS, Keasling JD. Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels. Curr Opin Biotechnol 2008, 19:556-563. 10.1016/j.copbio.2008.10.014, 18996194.
    • (2008) Curr Opin Biotechnol , vol.19 , pp. 556-563
    • Lee, S.K.1    Chou, H.2    Ham, T.S.3    Lee, T.S.4    Keasling, J.D.5
  • 3
    • 79959256632 scopus 로고    scopus 로고
    • Biotechnological production of polyamines by bacteria: recent achievements and future perspectives
    • 10.1007/s00253-011-3252-0, 21552989
    • Schneider J, Wendisch VF. Biotechnological production of polyamines by bacteria: recent achievements and future perspectives. Appl Microbiol Biotechnol 2011, 91:17-30. 10.1007/s00253-011-3252-0, 21552989.
    • (2011) Appl Microbiol Biotechnol , vol.91 , pp. 17-30
    • Schneider, J.1    Wendisch, V.F.2
  • 5
    • 82755189684 scopus 로고    scopus 로고
    • Microbial production of building block chemicals and polymers
    • 10.1016/j.copbio.2011.02.011, 21420291
    • Lee JW, Kim HU, Choi S, Yi J, Lee SY. Microbial production of building block chemicals and polymers. Curr Opin Biotechnol 2011, 22:758-767. 10.1016/j.copbio.2011.02.011, 21420291.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 758-767
    • Lee, J.W.1    Kim, H.U.2    Choi, S.3    Yi, J.4    Lee, S.Y.5
  • 6
    • 84867022890 scopus 로고    scopus 로고
    • Alternative biofuel production in non-natural hosts
    • 10.1016/j.copbio.2011.12.020, 22244690
    • McEwen JT, Atsumi S. Alternative biofuel production in non-natural hosts. Curr Opin Biotechnol 2012, 23:1-7. 10.1016/j.copbio.2011.12.020, 22244690.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 1-7
    • McEwen, J.T.1    Atsumi, S.2
  • 8
    • 78349254273 scopus 로고    scopus 로고
    • 1,3-Propanediol and its copolymers: research, development and industrialization
    • 10.1002/biot.201000140, 21058316
    • Liu H, Xu Y, Zheng Z, Liu D. 1,3-Propanediol and its copolymers: research, development and industrialization. Biotechnol J 2010, 5:1137-48. 10.1002/biot.201000140, 21058316.
    • (2010) Biotechnol J , vol.5 , pp. 1137-1148
    • Liu, H.1    Xu, Y.2    Zheng, Z.3    Liu, D.4
  • 9
    • 84867002579 scopus 로고    scopus 로고
    • Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA
    • Ohya N, Koyama PT. Biopolymers Online 2005, 73-81. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA.
    • (2005) Biopolymers Online , pp. 73-81
    • Ohya, N.1    Koyama, P.T.2
  • 10
    • 77955665708 scopus 로고    scopus 로고
    • Engineering Corynebacterium glutamicum for isobutanol production
    • 10.1007/s00253-010-2522-6, 2886118, 20376637
    • Smith KM, Cho K-M, Liao JC. Engineering Corynebacterium glutamicum for isobutanol production. Appl Microbiol Biotechnol 2010, 87:1045-55. 10.1007/s00253-010-2522-6, 2886118, 20376637.
    • (2010) Appl Microbiol Biotechnol , vol.87 , pp. 1045-1055
    • Smith, K.M.1    Cho, K.-M.2    Liao, J.C.3
  • 11
    • 78649716727 scopus 로고    scopus 로고
    • Manufacturing molecules through metabolic engineering
    • Keasling JD. Manufacturing molecules through metabolic engineering. Science (New York, N.Y.) 2010, (330):1355-8.
    • (2010) Science (New York, N.Y.) , Issue.330 , pp. 1355-1358
    • Keasling, J.D.1
  • 12
    • 79960163315 scopus 로고    scopus 로고
    • De novo engineering and metabolic flux analysis of inosine biosynthesis in Bacillus subtilis
    • 10.1007/s10529-011-0597-5, 21424839
    • Li H, Zhang G, Deng A, Chen N, Wen T. De novo engineering and metabolic flux analysis of inosine biosynthesis in Bacillus subtilis. Biotechnol Lett 2011, 33:1575-80. 10.1007/s10529-011-0597-5, 21424839.
    • (2011) Biotechnol Lett , vol.33 , pp. 1575-1580
    • Li, H.1    Zhang, G.2    Deng, A.3    Chen, N.4    Wen, T.5
  • 13
    • 80555150665 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for α-farnesene production
    • 10.1016/j.ymben.2011.08.001, 21907299
    • Wang C, Yoon S-H, Jang H-J, Chung Y-R, Kim J-Y, Choi E-S, Kim S-W. Metabolic engineering of Escherichia coli for α-farnesene production. Metab Eng 2011, 13:648-655. 10.1016/j.ymben.2011.08.001, 21907299.
    • (2011) Metab Eng , vol.13 , pp. 648-655
    • Wang, C.1    Yoon, S.-H.2    Jang, H.-J.3    Chung, Y.-R.4    Kim, J.-Y.5    Choi, E.-S.6    Kim, S.-W.7
  • 14
    • 84867013779 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid β-oxidation pathway
    • Gulevich AY, Skorokhodova AY, Sukhozhenko AV, Shakulov RS, Debabov VG. Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid β-oxidation pathway. Biotechnol Lett 2011,
    • (2011) Biotechnol Lett
    • Gulevich, A.Y.1    Skorokhodova, A.Y.2    Sukhozhenko, A.V.3    Shakulov, R.S.4    Debabov, V.G.5
  • 15
    • 79960712071 scopus 로고    scopus 로고
    • Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression
    • 10.1007/s00253-011-3280-9, 21533914
    • Li S, Wen J, Jia X. Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and the biosynthetic 2-ketoisovalerate precursor pathway overexpression. Appl Microbiol Biotechnol 2011, 91:577-89. 10.1007/s00253-011-3280-9, 21533914.
    • (2011) Appl Microbiol Biotechnol , vol.91 , pp. 577-589
    • Li, S.1    Wen, J.2    Jia, X.3
  • 17
    • 58149185126 scopus 로고    scopus 로고
    • BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009
    • 10.1093/nar/gkn820, 2686525, 18984617
    • Chang A, Scheer M, Grote A, Schomburg I, Schomburg D. BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009. Nucleic Acids Res 2009, 37:D588-92. 10.1093/nar/gkn820, 2686525, 18984617.
    • (2009) Nucleic Acids Res , vol.37
    • Chang, A.1    Scheer, M.2    Grote, A.3    Schomburg, I.4    Schomburg, D.5
  • 18
    • 0033963089 scopus 로고    scopus 로고
    • The ENZYME database in 2000
    • 10.1093/nar/28.1.304, 102465, 10592255
    • Bairoch A. The ENZYME database in 2000. Nucleic Acids Res 2000, 28:304-5. 10.1093/nar/28.1.304, 102465, 10592255.
    • (2000) Nucleic Acids Res , vol.28 , pp. 304-305
    • Bairoch, A.1
  • 19
    • 0141850380 scopus 로고    scopus 로고
    • PathMiner: predicting metabolic pathways by heuristic search
    • McShan DC, Rao S, Shah I. PathMiner: predicting metabolic pathways by heuristic search. Bioinformatics (Oxford, England) 2003, 19:1692-8.
    • (2003) Bioinformatics (Oxford, England) , vol.19 , pp. 1692-1698
    • McShan, D.C.1    Rao, S.2    Shah, I.3
  • 21
    • 26244437466 scopus 로고    scopus 로고
    • Expanding metabolic networks: scopes of compounds, robustness, and evolution
    • 10.1007/s00239-005-0027-1, 16155745
    • Handorf T, Ebenhöh O, Heinrich R. Expanding metabolic networks: scopes of compounds, robustness, and evolution. J Mol Evol 2005, 61:498-512. 10.1007/s00239-005-0027-1, 16155745.
    • (2005) J Mol Evol , vol.61 , pp. 498-512
    • Handorf, T.1    Ebenhöh, O.2    Heinrich, R.3
  • 23
    • 71549124335 scopus 로고    scopus 로고
    • Algorithms for effective querying of compound graph-based pathway databases
    • 10.1186/1471-2105-10-376, 2784781, 19917102
    • Dogrusoz U, Cetintas A, Demir E, Babur O. Algorithms for effective querying of compound graph-based pathway databases. BMC Bioinformatics 2009, 10:376. 10.1186/1471-2105-10-376, 2784781, 19917102.
    • (2009) BMC Bioinformatics , vol.10 , pp. 376
    • Dogrusoz, U.1    Cetintas, A.2    Demir, E.3    Babur, O.4
  • 24
    • 77953578214 scopus 로고    scopus 로고
    • Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3-hydroxypropanoate
    • Henry CS, Broadbelt LJ, Hatzimanikatis V. Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3-hydroxypropanoate. Biotechnol Bioeng 2010, 106:462-73.
    • (2010) Biotechnol Bioeng , vol.106 , pp. 462-473
    • Henry, C.S.1    Broadbelt, L.J.2    Hatzimanikatis, V.3
  • 25
    • 77953329895 scopus 로고    scopus 로고
    • Prediction of novel synthetic pathways for the production of desired chemicals
    • 10.1186/1752-0509-4-35, 2873314, 20346180
    • Cho A, Yun H, Park JH, Lee SY, Park S. Prediction of novel synthetic pathways for the production of desired chemicals. BMC Syst Biol 2010, 4:35. 10.1186/1752-0509-4-35, 2873314, 20346180.
    • (2010) BMC Syst Biol , vol.4 , pp. 35
    • Cho, A.1    Yun, H.2    Park, J.H.3    Lee, S.Y.4    Park, S.5
  • 26
    • 79957473580 scopus 로고    scopus 로고
    • Path finding methods accounting for stoichiometry in metabolic networks
    • 10.1186/gb-2011-12-5-r49, 3219972, 21619601
    • Varma A, Palsson BO. Path finding methods accounting for stoichiometry in metabolic networks. Genome Biol 2011, 12:R49. 10.1186/gb-2011-12-5-r49, 3219972, 21619601.
    • (2011) Genome Biol , vol.12
    • Varma, A.1    Palsson, B.O.2
  • 27
    • 79958753912 scopus 로고    scopus 로고
    • Probabilistic pathway construction
    • 10.1016/j.ymben.2011.01.006, 21292021
    • Yousofshahi M, Lee K, Hassoun S. Probabilistic pathway construction. Metab Eng 2011, 13:435-44. 10.1016/j.ymben.2011.01.006, 21292021.
    • (2011) Metab Eng , vol.13 , pp. 435-444
    • Yousofshahi, M.1    Lee, K.2    Hassoun, S.3
  • 28
    • 78651060607 scopus 로고    scopus 로고
    • SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants
    • 10.1186/1752-0509-5-5, 3024933, 21219666
    • Flórez LA, Gunka K, Polanía R, Tholen S, Stülke J. SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants. BMC Syst Biol 2011, 5:5. 10.1186/1752-0509-5-5, 3024933, 21219666.
    • (2011) BMC Syst Biol , vol.5 , pp. 5
    • Flórez, L.A.1    Gunka, K.2    Polanía, R.3    Tholen, S.4    Stülke, J.5
  • 30
    • 8744224466 scopus 로고    scopus 로고
    • OptStrain: A computational framework for redesign of microbial production systems
    • 10.1101/gr.2872004, 525696, 15520298
    • Pharkya P, Burgard AP, Maranas CD. OptStrain: A computational framework for redesign of microbial production systems. Genome Res 2004, 14:2367-2376. 10.1101/gr.2872004, 525696, 15520298.
    • (2004) Genome Res , vol.14 , pp. 2367-2376
    • Pharkya, P.1    Burgard, A.P.2    Maranas, C.D.3
  • 31
    • 0242487787 scopus 로고    scopus 로고
    • Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    • 10.1002/bit.10803, 14595777
    • Burgard AP, Pharkya P, Maranas CD. Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol Bioeng 2003, 84:647-57. 10.1002/bit.10803, 14595777.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 647-657
    • Burgard, A.P.1    Pharkya, P.2    Maranas, C.D.3
  • 32
    • 79955611425 scopus 로고    scopus 로고
    • Driving forces enable high-titer anaerobic 1-butanol synthesis in Escherichia coli
    • 10.1128/AEM.03034-10, 3126405, 21398484
    • Shen CR, Lan EI, Dekishima Y, Baez A, Cho KM, Liao JC. Driving forces enable high-titer anaerobic 1-butanol synthesis in Escherichia coli. Appl Environ Microbiol 2011, 77:2905-15. 10.1128/AEM.03034-10, 3126405, 21398484.
    • (2011) Appl Environ Microbiol , vol.77 , pp. 2905-2915
    • Shen, C.R.1    Lan, E.I.2    Dekishima, Y.3    Baez, A.4    Cho, K.M.5    Liao, J.C.6
  • 33
    • 79952582831 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of 1,2-propanediol from glycerol
    • 10.1002/bit.22993, 21404260
    • Clomburg JM, Gonzalez R. Metabolic engineering of Escherichia coli for the production of 1,2-propanediol from glycerol. Biotechnol Bioeng 2011, 108:867-79. 10.1002/bit.22993, 21404260.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 867-879
    • Clomburg, J.M.1    Gonzalez, R.2
  • 35
    • 84863003567 scopus 로고    scopus 로고
    • Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory
    • Becker J, Wittmann C. Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory. Curr Opin Biotechnol 2011, 23:1-10.
    • (2011) Curr Opin Biotechnol , vol.23 , pp. 1-10
    • Becker, J.1    Wittmann, C.2
  • 36
    • 84864186953 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries
    • CMLS, 10.1007/s00018-011-0833-0, 22009453
    • Hong K-K, Nielsen J. Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries. Cell Mol Life Sci 2012, 69:1-20. CMLS, 10.1007/s00018-011-0833-0, 22009453.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1-20
    • Hong, K.-K.1    Nielsen, J.2
  • 38
    • 70449372170 scopus 로고    scopus 로고
    • The importance of engineering physiological functionality into microbes
    • 10.1016/j.tibtech.2009.08.006, 19793618
    • Zhang Y, Zhu Y, Zhu Y, Li Y. The importance of engineering physiological functionality into microbes. Trends Biotechnol 2009, 27:664-72. 10.1016/j.tibtech.2009.08.006, 19793618.
    • (2009) Trends Biotechnol , vol.27 , pp. 664-672
    • Zhang, Y.1    Zhu, Y.2    Zhu, Y.3    Li, Y.4
  • 39
    • 65649126379 scopus 로고    scopus 로고
    • Connecting extracellular metabolomic measurements to intracellular flux states in yeast
    • 10.1186/1752-0509-3-37, 2679711, 19321003
    • Mo ML, Palsson BO, Herrgård MJ. Connecting extracellular metabolomic measurements to intracellular flux states in yeast. BMC Syst Biol 2009, 3:37. 10.1186/1752-0509-3-37, 2679711, 19321003.
    • (2009) BMC Syst Biol , vol.3 , pp. 37
    • Mo, M.L.1    Palsson, B.O.2    Herrgård, M.J.3
  • 40
    • 0344328817 scopus 로고    scopus 로고
    • An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    • 10.1186/gb-2003-4-9-r54, 193654, 12952533
    • Reed JL, Vo TD, Schilling CH, Palsson BO. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biol 2003, 4:R54. 10.1186/gb-2003-4-9-r54, 193654, 12952533.
    • (2003) Genome Biol , vol.4
    • Reed, J.L.1    Vo, T.D.2    Schilling, C.H.3    Palsson, B.O.4
  • 41
    • 69249154275 scopus 로고    scopus 로고
    • Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum
    • 10.1186/1475-2859-8-43, 2728707, 19646286
    • Shinfuku Y, Sorpitiporn N, Sono M, Furusawa C, Hirasawa T, Shimizu H. Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum. Microb Cell Fact 2009, 8:43. 10.1186/1475-2859-8-43, 2728707, 19646286.
    • (2009) Microb Cell Fact , vol.8 , pp. 43
    • Shinfuku, Y.1    Sorpitiporn, N.2    Sono, M.3    Furusawa, C.4    Hirasawa, T.5    Shimizu, H.6
  • 42
    • 0003450992 scopus 로고    scopus 로고
    • Enzyme Nomenclature
    • Enzyme Nomenclature. [http://www.chem.qmul.ac.uk/iubmb/enzyme/].
  • 43
    • 77749320898 scopus 로고    scopus 로고
    • What is flux balance analysis?
    • 10.1038/nbt.1614, 3108565, 20212490
    • Orth JD, Thiele I, Palsson B. What is flux balance analysis?. Nat Biotechnol 2010, 28:245-8. 10.1038/nbt.1614, 3108565, 20212490.
    • (2010) Nat Biotechnol , vol.28 , pp. 245-248
    • Orth, J.D.1    Thiele, I.2    Palsson, B.3
  • 44
    • 0142122303 scopus 로고    scopus 로고
    • Advances in flux balance analysis
    • 10.1016/j.copbio.2003.08.001, 14580578
    • Kauffman KJ, Prakash P, Edwards JS. Advances in flux balance analysis. Curr Opin Biotechnol 2003, 14:491-6. 10.1016/j.copbio.2003.08.001, 14580578.
    • (2003) Curr Opin Biotechnol , vol.14 , pp. 491-496
    • Kauffman, K.J.1    Prakash, P.2    Edwards, J.S.3
  • 45
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    • 1949037, 17625511
    • Schuetz R, Kuepfer L, Sauer U. Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli. Mol Syst Biol 2007, 3:119. 1949037, 17625511.
    • (2007) Mol Syst Biol , vol.3 , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 47
    • 79958232375 scopus 로고    scopus 로고
    • Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway
    • 10.1007/s00253-011-3199-1, 21468716
    • Zhao Y, Yang J, Qin B, Li Y, Sun Y, Su S, Xian M. Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway. Appl Microbiol Biotechnol 2011, 90:1915-22. 10.1007/s00253-011-3199-1, 21468716.
    • (2011) Appl Microbiol Biotechnol , vol.90 , pp. 1915-1922
    • Zhao, Y.1    Yang, J.2    Qin, B.3    Li, Y.4    Sun, Y.5    Su, S.6    Xian, M.7
  • 48
    • 0037279839 scopus 로고    scopus 로고
    • Poly(3-hydroxybutyrate) (PHB) synthesis by recombinant Escherichia coli harbouring Streptomyces aureofaciens PHB biosynthesis genes: effect of various carbon and nitrogen sources
    • 10.1078/0944-5013-00161, 12608576
    • Mahishi LH, Tripathi G, Rawal SK. Poly(3-hydroxybutyrate) (PHB) synthesis by recombinant Escherichia coli harbouring Streptomyces aureofaciens PHB biosynthesis genes: effect of various carbon and nitrogen sources. Microbiol Res 2003, 158:19-27. 10.1078/0944-5013-00161, 12608576.
    • (2003) Microbiol Res , vol.158 , pp. 19-27
    • Mahishi, L.H.1    Tripathi, G.2    Rawal, S.K.3
  • 49
    • 77953231876 scopus 로고    scopus 로고
    • Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane
    • 10.1016/j.ymben.2010.03.005, 20381632
    • Kind S, Jeong WK, Schröder H, Wittmann C. Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metab Eng 2010, 12:341-51. 10.1016/j.ymben.2010.03.005, 20381632.
    • (2010) Metab Eng , vol.12 , pp. 341-351
    • Kind, S.1    Jeong, W.K.2    Schröder, H.3    Wittmann, C.4
  • 50
    • 33645851015 scopus 로고    scopus 로고
    • Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae
    • 10.1007/s10529-006-0015-6, 16614895
    • Lindahl A-L, Olsson ME, Mercke P, Tollbom O, Schelin J, Brodelius M, Brodelius PE. Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. Biotechnol Lett 2006, 28:571-80. 10.1007/s10529-006-0015-6, 16614895.
    • (2006) Biotechnol Lett , vol.28 , pp. 571-580
    • Lindahl, A.-L.1    Olsson, M.E.2    Mercke, P.3    Tollbom, O.4    Schelin, J.5    Brodelius, M.6    Brodelius, P.E.7
  • 51
    • 0035129779 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
    • 10.1007/s004250000428, 11289612
    • Wallaart TE, Bouwmeester HJ, Hille J, Poppinga L, Maijers NC. Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin. Planta 2001, 212:460-5. 10.1007/s004250000428, 11289612.
    • (2001) Planta , vol.212 , pp. 460-465
    • Wallaart, T.E.1    Bouwmeester, H.J.2    Hille, J.3    Poppinga, L.4    Maijers, N.C.5
  • 52
    • 0142027026 scopus 로고    scopus 로고
    • Metabolic engineering for the microbial production of 1,3-propanediol
    • 10.1016/j.copbio.2003.08.005, 14580573
    • Nakamura CE, Whited GM. Metabolic engineering for the microbial production of 1,3-propanediol. Curr Opin Biotechnol 2003, 14:454-9. 10.1016/j.copbio.2003.08.005, 14580573.
    • (2003) Curr Opin Biotechnol , vol.14 , pp. 454-459
    • Nakamura, C.E.1    Whited, G.M.2
  • 53
    • 0031930240 scopus 로고    scopus 로고
    • Metabolic engineering of propanediol pathways
    • 10.1021/bp9701325, 9496676
    • Cameron DC, Altaras NE, Hoffman ML, Shaw AJ. Metabolic engineering of propanediol pathways. Biotechnol Prog 1998, 14:116-25. 10.1021/bp9701325, 9496676.
    • (1998) Biotechnol Prog , vol.14 , pp. 116-125
    • Cameron, D.C.1    Altaras, N.E.2    Hoffman, M.L.3    Shaw, A.J.4
  • 54
    • 25444479070 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions
    • 10.1159/000086705, 16179801
    • Inui M, Kawaguchi H, Murakami S, Vertès AA, Yukawa H. Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol 2004, 8:243-54. 10.1159/000086705, 16179801.
    • (2004) J Mol Microbiol Biotechnol , vol.8 , pp. 243-254
    • Inui, M.1    Kawaguchi, H.2    Murakami, S.3    Vertès, A.A.4    Yukawa, H.5
  • 55
    • 77949448789 scopus 로고    scopus 로고
    • Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli
    • 10.1002/biot.200900279, 20213636
    • Nielsen DR, Yoon S-H, Yuan CJ, Prather KLJ. Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli. Biotechnol J 2010, 5:274-84. 10.1002/biot.200900279, 20213636.
    • (2010) Biotechnol J , vol.5 , pp. 274-284
    • Nielsen, D.R.1    Yoon, S.-H.2    Yuan, C.J.3    Prather, K.L.J.4
  • 56
    • 0032984973 scopus 로고    scopus 로고
    • Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli
    • 91161, 10049880
    • Altaras NE, Cameron DC. Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli. Appl Environ Microbiol 1999, 65:1180-5. 91161, 10049880.
    • (1999) Appl Environ Microbiol , vol.65 , pp. 1180-1185
    • Altaras, N.E.1    Cameron, D.C.2
  • 57
    • 29544439347 scopus 로고    scopus 로고
    • Application of sequential integration for metabolic engineering of 1,2-propanediol production in yeast
    • 10.1016/j.ymben.2005.09.001, 16242982
    • Lee W, Dasilva NA. Application of sequential integration for metabolic engineering of 1,2-propanediol production in yeast. Metab Eng 2006, 8:58-65. 10.1016/j.ymben.2005.09.001, 16242982.
    • (2006) Metab Eng , vol.8 , pp. 58-65
    • Lee, W.1    Dasilva, N.A.2
  • 58
    • 0036010273 scopus 로고    scopus 로고
    • Benzene-free synthesis of adipic acid
    • 10.1021/bp010179x, 11934286
    • Niu W, Draths KM, Frost JW. Benzene-free synthesis of adipic acid. Biotechnol Prog 2002, 18:201-11. 10.1021/bp010179x, 11934286.
    • (2002) Biotechnol Prog , vol.18 , pp. 201-211
    • Niu, W.1    Draths, K.M.2    Frost, J.W.3
  • 59
    • 0034625143 scopus 로고    scopus 로고
    • The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities
    • 10.1073/pnas.97.10.5528, 25862, 10805808
    • Edwards JS, Palsson BO. The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proc Natl Acad Sci U S A 2000, 97:5528-33. 10.1073/pnas.97.10.5528, 25862, 10805808.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5528-5533
    • Edwards, J.S.1    Palsson, B.O.2
  • 60
    • 0028146781 scopus 로고
    • Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110
    • 201879, 7986045
    • Varma A, Palsson BO. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl Environ Microbiol 1994, 60:3724-31. 201879, 7986045.
    • (1994) Appl Environ Microbiol , vol.60 , pp. 3724-3731
    • Varma, A.1    Palsson, B.O.2
  • 61
    • 77952886804 scopus 로고    scopus 로고
    • The biomass objective function
    • 10.1016/j.mib.2010.03.003, 2912156, 20430689
    • Feist AM, Palsson BO. The biomass objective function. Curr Opin Microbiol 2010, 13:344-9. 10.1016/j.mib.2010.03.003, 2912156, 20430689.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 344-349
    • Feist, A.M.1    Palsson, B.O.2
  • 62
    • 0035125986 scopus 로고    scopus 로고
    • In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
    • 10.1038/84379, 11175725
    • Edwards JS, Ibarra RU, Palsson BO. In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 2001, 19:125-30. 10.1038/84379, 11175725.
    • (2001) Nat Biotechnol , vol.19 , pp. 125-130
    • Edwards, J.S.1    Ibarra, R.U.2    Palsson, B.O.3
  • 63
    • 0142152457 scopus 로고    scopus 로고
    • Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model
    • 10.1128/JB.185.21.6400-6408.2003, 219384, 14563875
    • Fong SS, Marciniak JY, Palsson B. Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model. J Bacteriol 2003, 185:6400-8. 10.1128/JB.185.21.6400-6408.2003, 219384, 14563875.
    • (2003) J Bacteriol , vol.185 , pp. 6400-6408
    • Fong, S.S.1    Marciniak, J.Y.2    Palsson, B.3
  • 64
    • 2942579562 scopus 로고    scopus 로고
    • Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions
    • 10.1186/1471-2105-1-1, 29061, 11001586
    • Edwards JS, Palsson BO. Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions. BMC Bioinformatics 2000, 1:1. 10.1186/1471-2105-1-1, 29061, 11001586.
    • (2000) BMC Bioinformatics , vol.1 , pp. 1
    • Edwards, J.S.1    Palsson, B.O.2
  • 65
    • 78049422553 scopus 로고    scopus 로고
    • Evolution under fluctuating environments explains observed robustness in metabolic networks
    • Soyer OS, Pfeiffer T. Evolution under fluctuating environments explains observed robustness in metabolic networks. PLoS Comput Biol 2010, 6.
    • (2010) PLoS Comput Biol , vol.6
    • Soyer, O.S.1    Pfeiffer, T.2
  • 66
    • 79952773308 scopus 로고    scopus 로고
    • Dispensability of Escherichia coli's latent pathways
    • 10.1073/pnas.1009772108, 3044393, 21300895
    • Cornelius SP, Lee JS, Motter AE. Dispensability of Escherichia coli's latent pathways. Proc Natl Acad Sci U S A 2011, 108:3124-9. 10.1073/pnas.1009772108, 3044393, 21300895.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3124-3129
    • Cornelius, S.P.1    Lee, J.S.2    Motter, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.