Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1484-1489

  Soo, Valerie W C ^a   Hanson Manful, Paulina ^a   Patrick, Wayne M ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

Antibiotic resistance; Evolutionary innovation; Molecular evolution; Phenotype microarray; Protein promiscuity

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AZTREONAM; BENZETHONIUM CHLORIDE; BETA LACTAM ANTIBIOTIC; CEFALOTIN; CEFUROXIME; CIPROFLOXACIN; ENOXACIN; ERYTHROMYCIN; FOLIC ACID ANTAGONIST; LINCOMYCIN; NALIDIXIC ACID; NITROFURAN DERIVATIVE; NITROFURANTOIN; OXYTETRACYCLINE; PENICILLIN G; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; RIFAMYCIN; SISOMICIN; SPIRAMYCIN; STEROID; SULFADIAZINE; TOBRAMYCIN; TOXIN; TRIMETHOPRIM; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENOME; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE DUPLICATION; GENE EXPRESSION; GENE LIBRARY; GENE OVEREXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; GENE AMPLIFICATION; GENE DUPLICATION; GENE LIBRARY; MICROBIAL SENSITIVITY TESTS; MODELS, GENETIC; MUTATION; OPEN READING FRAMES; SELECTION, GENETIC;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 79952166228     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1012108108     Document Type: Article

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