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Volumn 273, Issue 2, 2016, Pages 495-503

Glutaminolysis and carcinogenesis of oral squamous cell carcinoma

Author keywords

Glutaminolysis; Oral squamous cell carcinoma; Tumor metabolism

Indexed keywords

AMINO ACID TRANSPORTER; GLUTAMATE DEHYDROGENASE; GLUTAMINE; HEXOSAMINE; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NEUTRAL AMINO ACID TRANSPORTER 2; NUCLEOTIDE; PROTEIN; SOLUTE CARRIER FAMILY 1 MEMBER 5; UNCLASSIFIED DRUG; GALACTONOLACTONE DEHYDROGENASE; GLUTAMINASE; OXIDOREDUCTASE; RNA; SLC1A4 PROTEIN, HUMAN; SLC1A5 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84956604846     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-015-3543-7     Document Type: Article
Times cited : (25)

References (59)
  • 1
    • 84904445937 scopus 로고    scopus 로고
    • Association of cancer metabolism-related proteins with oral carcinogenesis-indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?
    • PID: 25048361
    • Grimm M, Cetindis M, Lehmann M, Biegner T, Munz A, Teriete P, Kraut W, Reinert S (2014) Association of cancer metabolism-related proteins with oral carcinogenesis-indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma? J Transl Med 12:208. doi:10.1186/1479-5876-12-208
    • (2014) J Transl Med , vol.12 , pp. 208
    • Grimm, M.1    Cetindis, M.2    Lehmann, M.3    Biegner, T.4    Munz, A.5    Teriete, P.6    Kraut, W.7    Reinert, S.8
  • 2
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: cell biology, physiology, and clinical opportunities
    • PID: 23999442, COI: 1:CAS:528:DC%2BC3sXhsVenu7bL
    • Hensley CT, Wasti AT, DeBerardinis RJ (2013) Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Investig 123(9):3678–3684. doi:10.1172/JCI69600
    • (2013) J Clin Investig , vol.123 , Issue.9 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 3
    • 80053185587 scopus 로고    scopus 로고
    • Evolution of tumor metabolism might reflect carcinogenesis as a reverse evolution process (dismantling of multicellularity)
    • COI: 1:CAS:528:DC%2BC3MXhtVGqsrbI
    • Alfarouk KO, Shayoub ME, Muddathir AK, Elhassan GO, Bashir AH (2011) Evolution of tumor metabolism might reflect carcinogenesis as a reverse evolution process (dismantling of multicellularity). Cancers (Basel) 3(3):3002–3017. doi:10.3390/cancers3033002
    • (2011) Cancers (Basel) , vol.3 , Issue.3 , pp. 3002-3017
    • Alfarouk, K.O.1    Shayoub, M.E.2    Muddathir, A.K.3    Elhassan, G.O.4    Bashir, A.H.5
  • 4
    • 84904819009 scopus 로고    scopus 로고
    • Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach
    • PID: 24927638
    • Ogawa T, Washio J, Takahashi T, Echigo S, Takahashi N (2014) Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach. Oral Surg Oral Med Oral Pathol Oral Radiol 118(2):218–225. doi:10.1016/j.oooo.2014.04.003
    • (2014) Oral Surg Oral Med Oral Pathol Oral Radiol , vol.118 , Issue.2 , pp. 218-225
    • Ogawa, T.1    Washio, J.2    Takahashi, T.3    Echigo, S.4    Takahashi, N.5
  • 5
    • 79959588949 scopus 로고    scopus 로고
    • Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells
    • PID: 21692052, COI: 1:CAS:528:DC%2BC3MXns1Klurs%3D
    • Sandulache VC, Ow TJ, Pickering CR, Frederick MJ, Zhou G, Fokt I, Davis-Malesevich M, Priebe W, Myers JN (2011) Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer 117(13):2926–2938. doi:10.1002/cncr.25868
    • (2011) Cancer , vol.117 , Issue.13 , pp. 2926-2938
    • Sandulache, V.C.1    Ow, T.J.2    Pickering, C.R.3    Frederick, M.J.4    Zhou, G.5    Fokt, I.6    Davis-Malesevich, M.7    Priebe, W.8    Myers, J.N.9
  • 8
    • 0037372730 scopus 로고    scopus 로고
    • Glutamine and glutamate—their central role in cell metabolism and function
    • PID: 12579515, COI: 1:CAS:528:DC%2BD3sXhs1Snsb0%3D
    • Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R (2003) Glutamine and glutamate—their central role in cell metabolism and function. Cell Biochem Funct 21(1):1–9. doi:10.1002/cbf.1003
    • (2003) Cell Biochem Funct , vol.21 , Issue.1 , pp. 1-9
    • Newsholme, P.1    Procopio, J.2    Lima, M.M.3    Pithon-Curi, T.C.4    Curi, R.5
  • 9
    • 84902208195 scopus 로고    scopus 로고
    • Importance of glutamine metabolism in leukemia cells by energy production through TCA cycle and by redox homeostasis
    • COI: 1:CAS:528:DC%2BC2cXps1Wit70%3D
    • Goto M, Miwa H, Shikami M, Tsunekawa-Imai N, Suganuma K, Mizuno S, Takahashi M, Mizutani M, Hanamura I, Nitta M (2014) Importance of glutamine metabolism in leukemia cells by energy production through TCA cycle and by redox homeostasis. Cancer Investig 32(6):241–247. doi:10.3109/07357907.2014.907419
    • (2014) Cancer Investig , vol.32 , Issue.6 , pp. 241-247
    • Goto, M.1    Miwa, H.2    Shikami, M.3    Tsunekawa-Imai, N.4    Suganuma, K.5    Mizuno, S.6    Takahashi, M.7    Mizutani, M.8    Hanamura, I.9    Nitta, M.10
  • 10
    • 43749083041 scopus 로고    scopus 로고
    • Brick by brick: metabolism and tumor cell growth
    • PID: 18387799, COI: 1:CAS:528:DC%2BD1cXmsVartbg%3D
    • Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB (2008) Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 18(1):54–61. doi:10.1016/j.gde.2008.02.003
    • (2008) Curr Opin Genet Dev , vol.18 , Issue.1 , pp. 54-61
    • Deberardinis, R.J.1    Sayed, N.2    Ditsworth, D.3    Thompson, C.B.4
  • 11
    • 33645009423 scopus 로고    scopus 로고
    • Current classification of precursor lesions of oral squamous cell carcinoma principles of the WHO classification 2005
    • PID: 16485137, COI: 1:STN:280:DC%2BD287kvFWisg%3D%3D
    • Driemel O, Hertel K, Reichert TE, Kosmehl H (2006) Current classification of precursor lesions of oral squamous cell carcinoma principles of the WHO classification 2005. Mund Kiefer Gesichtschir 10(2):89–93. doi:10.1007/s10006-006-0675-3
    • (2006) Mund Kiefer Gesichtschir , vol.10 , Issue.2 , pp. 89-93
    • Driemel, O.1    Hertel, K.2    Reichert, T.E.3    Kosmehl, H.4
  • 12
    • 84855520018 scopus 로고    scopus 로고
    • Oral carcinogenesis and oral cancer chemoprevention: a review
    • Tanaka T, Tanaka M, Tanaka T (2011) Oral carcinogenesis and oral cancer chemoprevention: a review. Pathol Res Int 2011:431246. doi:10.4061/2011/431246
    • (2011) Pathol Res Int , vol.2011 , pp. 431246
    • Tanaka, T.1    Tanaka, M.2    Tanaka, T.3
  • 15
    • 33748752115 scopus 로고    scopus 로고
    • Quantification of immunohistochemistry—issues concerning methods, utility and semiquantitative assessment I
    • PID: 16978204, COI: 1:STN:280:DC%2BD28rlsVSktA%3D%3D
    • Walker RA (2006) Quantification of immunohistochemistry—issues concerning methods, utility and semiquantitative assessment I. Histopathology 49(4):406–410. doi:10.1111/j.1365-2559.2006.02514.x
    • (2006) Histopathology , vol.49 , Issue.4 , pp. 406-410
    • Walker, R.A.1
  • 16
    • 40149095419 scopus 로고    scopus 로고
    • Analysis of OPLA scaffolds for bone engineering constructs using human jaw periosteal cells
    • PID: 18158613, COI: 1:CAS:528:DC%2BD1cXis1Whs7s%3D
    • Alexander D, Hoffmann J, Munz A, Friedrich B, Geis-Gerstorfer J, Reinert S (2008) Analysis of OPLA scaffolds for bone engineering constructs using human jaw periosteal cells. J Mater Sci Mater Med 19(3):965–974. doi:10.1007/s10856-007-3351-8
    • (2008) J Mater Sci Mater Med , vol.19 , Issue.3 , pp. 965-974
    • Alexander, D.1    Hoffmann, J.2    Munz, A.3    Friedrich, B.4    Geis-Gerstorfer, J.5    Reinert, S.6
  • 17
    • 79959685526 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNFR family-related receptor (GITR)-expression in tumor infiltrating leucocytes (TILs) is associated with the pathogenesis of esophageal adenocarcinomas with and without Barrett’s mucosa
    • von Rahden BH, Kircher S, Kafka M, Stuermer L, Reiber C, Gattenlohner S, Germer CT, Grimm M (2010) Glucocorticoid-induced TNFR family-related receptor (GITR)-expression in tumor infiltrating leucocytes (TILs) is associated with the pathogenesis of esophageal adenocarcinomas with and without Barrett’s mucosa. Cancer Biomark Sect A Dis Markers 7(6):285–294. doi:10.3233/CBM-2010-0192
    • (2010) Cancer Biomark Sect A Dis Markers , vol.7 , Issue.6 , pp. 285-294
    • von Rahden, B.H.1    Kircher, S.2    Kafka, M.3    Stuermer, L.4    Reiber, C.5    Gattenlohner, S.6    Germer, C.T.7    Grimm, M.8
  • 18
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    • PID: 18784658, COI: 1:CAS:528:DC%2BD1cXhtFCrtb3K
    • Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8(10):755–768. doi:10.1038/nrc2499
    • (2008) Nat Rev Cancer , vol.8 , Issue.10 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 19
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • PID: 959840, COI: 1:STN:280:DyaE283ntFWmsw%3D%3D
    • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194(4260):23–28
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 20
    • 35848964790 scopus 로고    scopus 로고
    • Breast tumor heterogeneity: cancer stem cells or clonal evolution?
    • PID: 17786053, COI: 1:CAS:528:DC%2BD2sXhtlKkt7jK
    • Campbell LL, Polyak K (2007) Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle 6(19):2332–2338. doi:10.4161/cc.6.19.4914
    • (2007) Cell Cycle , vol.6 , Issue.19 , pp. 2332-2338
    • Campbell, L.L.1    Polyak, K.2
  • 21
    • 70350217425 scopus 로고    scopus 로고
    • Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling
    • PID: 19826036, COI: 1:CAS:528:DC%2BD1MXht1ynurbK
    • Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ (2009) Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res 69(20):7986–7993. doi:10.1158/0008-5472.CAN-09-2266
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 7986-7993
    • Yang, C.1    Sudderth, J.2    Dang, T.3    Bachoo, R.M.4    McDonald, J.G.5    DeBerardinis, R.J.6
  • 22
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • PID: 20513425, COI: 1:CAS:528:DC%2BC3cXns1SlsLw%3D
    • Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J (2010) Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 38(4):487–499. doi:10.1016/j.molcel.2010.05.007
    • (2010) Mol Cell , vol.38 , Issue.4 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 23
    • 84860316773 scopus 로고    scopus 로고
    • Carbon source metabolism and its regulation in cancer cells
    • PID: 22339657, COI: 1:CAS:528:DC%2BC38Xlt1WgtLo%3D
    • Yin C, Qie S, Sang N (2012) Carbon source metabolism and its regulation in cancer cells. Crit Rev Eukaryot Gene Expr 22(1):17–35
    • (2012) Crit Rev Eukaryot Gene Expr , vol.22 , Issue.1 , pp. 17-35
    • Yin, C.1    Qie, S.2    Sang, N.3
  • 24
    • 0037093411 scopus 로고    scopus 로고
    • Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells
    • PID: 11988105, COI: 1:CAS:528:DC%2BD38XktFWhs7c%3D
    • Guppy M, Leedman P, Zu X, Russell V (2002) Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells. Biochem J 364(Pt 1):309–315
    • (2002) Biochem J , vol.364 , pp. 309-315
    • Guppy, M.1    Leedman, P.2    Zu, X.3    Russell, V.4
  • 25
    • 77958478353 scopus 로고    scopus 로고
    • Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells
    • PID: 20935507, COI: 1:CAS:528:DC%2BC3MXhsVent70%3D
    • Meng M, Chen S, Lao T, Liang D, Sang N (2010) Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells. Cell Cycle 9(19):3921–3932
    • (2010) Cell Cycle , vol.9 , Issue.19 , pp. 3921-3932
    • Meng, M.1    Chen, S.2    Lao, T.3    Liang, D.4    Sang, N.5
  • 26
    • 77958492734 scopus 로고    scopus 로고
    • Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?
    • PID: 20948290, COI: 1:CAS:528:DC%2BC3MXhsVentrY%3D
    • Dang CV (2010) Glutaminolysis: supplying carbon or nitrogen or both for cancer cells? Cell Cycle 9(19):3884–3886
    • (2010) Cell Cycle , vol.9 , Issue.19 , pp. 3884-3886
    • Dang, C.V.1
  • 27
    • 78650181190 scopus 로고    scopus 로고
    • The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
    • PID: 21106670, COI: 1:CAS:528:DC%2BC3MXltVKn
    • Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB (2010) The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev 24(24):2784–2799. doi:10.1101/gad.1985910
    • (2010) Genes Dev , vol.24 , Issue.24 , pp. 2784-2799
    • Wellen, K.E.1    Lu, C.2    Mancuso, A.3    Lemons, J.M.4    Ryczko, M.5    Dennis, J.W.6    Rabinowitz, J.D.7    Coller, H.A.8    Thompson, C.B.9
  • 28
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • PID: 17606868, COI: 1:CAS:528:DC%2BD2sXnsVajurY%3D
    • Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y (2007) Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 178(1):93–105. doi:10.1083/jcb.200703099
    • (2007) J Cell Biol , vol.178 , Issue.1 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5
  • 33
    • 72449146809 scopus 로고    scopus 로고
    • Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis
    • PID: 19424974
    • Shah NG, Trivedi TI, Tankshali RA, Goswami JV, Jetly DH, Shukla SN, Shah PM, Verma RJ (2009) Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis. Head Neck 31(12):1544–1556. doi:10.1002/hed.21126
    • (2009) Head Neck , vol.31 , Issue.12 , pp. 1544-1556
    • Shah, N.G.1    Trivedi, T.I.2    Tankshali, R.A.3    Goswami, J.V.4    Jetly, D.H.5    Shukla, S.N.6    Shah, P.M.7    Verma, R.J.8
  • 34
    • 60149095682 scopus 로고    scopus 로고
    • Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells
    • PID: 19073877
    • Su Y, Simmen RC (2009) Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells. Carcinogenesis 30(2):331–339. doi:10.1093/carcin/bgn279
    • (2009) Carcinogenesis , vol.30 , Issue.2 , pp. 331-339
    • Su, Y.1    Simmen, R.C.2
  • 35
    • 42349094502 scopus 로고    scopus 로고
    • Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model
    • PID: 18413778, COI: 1:CAS:528:DC%2BD1cXks1Ghs7o%3D
    • Kobayashi N, Barnard RJ, Said J, Hong-Gonzalez J, Corman DM, Ku M, Doan NB, Gui D, Elashoff D, Cohen P, Aronson WJ (2008) Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model. Cancer Res 68(8):3066–3073. doi:10.1158/0008-5472.CAN-07-5616
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 3066-3073
    • Kobayashi, N.1    Barnard, R.J.2    Said, J.3    Hong-Gonzalez, J.4    Corman, D.M.5    Ku, M.6    Doan, N.B.7    Gui, D.8    Elashoff, D.9    Cohen, P.10    Aronson, W.J.11
  • 36
    • 69849095827 scopus 로고    scopus 로고
    • Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model
    • PID: 19642983
    • Du YP, Peng JS, Sun A, Tang ZH, Ling WH, Zhu HL (2009) Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model. BMC Cancer 9:261. doi:10.1186/1471-2407-9-261
    • (2009) BMC Cancer , vol.9 , pp. 261
    • Du, Y.P.1    Peng, J.S.2    Sun, A.3    Tang, Z.H.4    Ling, W.H.5    Zhu, H.L.6
  • 37
    • 63849329840 scopus 로고    scopus 로고
    • Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer
    • PID: 19098451
    • Lu R, Wang X, Sun DF, Tian XQ, Zhao SL, Chen YX, Fang JY (2008) Folic acid and sodium butyrate prevent tumorigenesis in a mouse model of colorectal cancer. Epigenetics 3(6):330–335
    • (2008) Epigenetics , vol.3 , Issue.6 , pp. 330-335
    • Lu, R.1    Wang, X.2    Sun, D.F.3    Tian, X.Q.4    Zhao, S.L.5    Chen, Y.X.6    Fang, J.Y.7
  • 38
    • 80053193812 scopus 로고    scopus 로고
    • Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site
    • PID: 21813650, COI: 1:CAS:528:DC%2BC3MXht1ajtb%2FF
    • Li C, Li M, Chen P, Narayan S, Matschinsky FM, Bennett MJ, Stanley CA, Smith TJ (2011) Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site. J Biol Chem 286(39):34164–34174. doi:10.1074/jbc.M111.268599
    • (2011) J Biol Chem , vol.286 , Issue.39 , pp. 34164-34174
    • Li, C.1    Li, M.2    Chen, P.3    Narayan, S.4    Matschinsky, F.M.5    Bennett, M.J.6    Stanley, C.A.7    Smith, T.J.8
  • 39
    • 0027787467 scopus 로고
    • The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro
    • PID: 8138012, COI: 1:CAS:528:DyaK2cXpsFSksg%3D%3D
    • Griffiths M, Keast D, Patrick G, Crawford M, Palmer TN (1993) The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro. Int J Biochem 25(12):1749–1755
    • (1993) Int J Biochem , vol.25 , Issue.12 , pp. 1749-1755
    • Griffiths, M.1    Keast, D.2    Patrick, G.3    Crawford, M.4    Palmer, T.N.5
  • 40
    • 0025232412 scopus 로고
    • Metabolism and action of amino acid analog anti-cancer agents
    • PID: 2108451, COI: 1:CAS:528:DyaK3cXhslWmtbc%3D
    • Ahluwalia GS, Grem JL, Hao Z, Cooney DA (1990) Metabolism and action of amino acid analog anti-cancer agents. Pharmacol Ther 46(2):243–271
    • (1990) Pharmacol Ther , vol.46 , Issue.2 , pp. 243-271
    • Ahluwalia, G.S.1    Grem, J.L.2    Hao, Z.3    Cooney, D.A.4
  • 42
    • 84869381457 scopus 로고    scopus 로고
    • Glutaminolysis feeds mTORC1
    • PID: 23095634, COI: 1:CAS:528:DC%2BC3sXhsFSgtb0%3D
    • Duran RV, Hall MN (2012) Glutaminolysis feeds mTORC1. Cell Cycle 11(22):4107–4108. doi:10.4161/cc.22632
    • (2012) Cell Cycle , vol.11 , Issue.22 , pp. 4107-4108
    • Duran, R.V.1    Hall, M.N.2
  • 43
    • 42449159315 scopus 로고    scopus 로고
    • Possible involvement of persistent activity of the mammalian target of rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells
    • PID: 17568186, COI: 1:CAS:528:DC%2BD2sXhsVWksrbK
    • Kamata S, Kishimoto T, Kobayashi S, Miyazaki M, Ishikura H (2007) Possible involvement of persistent activity of the mammalian target of rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells. Cancer Biol Ther 6(7):1036–1043
    • (2007) Cancer Biol Ther , vol.6 , Issue.7 , pp. 1036-1043
    • Kamata, S.1    Kishimoto, T.2    Kobayashi, S.3    Miyazaki, M.4    Ishikura, H.5
  • 44
    • 77957891539 scopus 로고    scopus 로고
    • RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase
    • PID: 20727673, COI: 1:CAS:528:DC%2BC3cXhtlShtrfP
    • Lee KH, Hur HS, Im SA, Lee J, Kim HP, Yoon YK, Han SW, Song SH, Oh DY, Kim TY, Bang YJ (2010) RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase. Cancer Lett 299(1):22–28. doi:10.1016/j.canlet.2010.07.020
    • (2010) Cancer Lett , vol.299 , Issue.1 , pp. 22-28
    • Lee, K.H.1    Hur, H.S.2    Im, S.A.3    Lee, J.4    Kim, H.P.5    Yoon, Y.K.6    Han, S.W.7    Song, S.H.8    Oh, D.Y.9    Kim, T.Y.10    Bang, Y.J.11
  • 45
    • 84906309219 scopus 로고    scopus 로고
    • RAD001 enhances the radiosensitivity of SCC4 oral cancer cells by inducing cell cycle arrest at the G2/M checkpoint
    • PID: 24922656, COI: 1:CAS:528:DC%2BC2cXhtFGrtrrI
    • Yu CC, Hung SK, Liao HF, Lee CC, Lin HY, Lai HC, Li SC, Ho HC, Huang HB, Su YC (2014) RAD001 enhances the radiosensitivity of SCC4 oral cancer cells by inducing cell cycle arrest at the G2/M checkpoint. Anticancer Res 34(6):2927–2935
    • (2014) Anticancer Res , vol.34 , Issue.6 , pp. 2927-2935
    • Yu, C.C.1    Hung, S.K.2    Liao, H.F.3    Lee, C.C.4    Lin, H.Y.5    Lai, H.C.6    Li, S.C.7    Ho, H.C.8    Huang, H.B.9    Su, Y.C.10
  • 47
    • 79953650247 scopus 로고    scopus 로고
    • mTOR upregulation of glycolytic enzymes promotes tumor development
    • PID: 21393998, COI: 1:CAS:528:DC%2BC3MXhs1WltbvP
    • Zha X, Sun Q, Zhang H (2011) mTOR upregulation of glycolytic enzymes promotes tumor development. Cell Cycle 10(7):1015–1016
    • (2011) Cell Cycle , vol.10 , Issue.7 , pp. 1015-1016
    • Zha, X.1    Sun, Q.2    Zhang, H.3
  • 50
    • 84871249684 scopus 로고    scopus 로고
    • Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC
    • PID: 22855158, COI: 1:STN:280:DC%2BC38fkvFSrtA%3D%3D
    • Grimm M (2012) Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC. Clin Transl Oncol 14(11):870–880. doi:10.1007/s12094-012-0867-2
    • (2012) Clin Transl Oncol , vol.14 , Issue.11 , pp. 870-880
    • Grimm, M.1
  • 52
    • 0018123526 scopus 로고
    • Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase
    • PID: 363626, COI: 1:CAS:528:DyaE1MXpslCjtQ%3D%3D
    • Wu MC, Arimura GK, Yunis AA (1978) Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int J Cancer Journal international du cancer 22(6):728–733
    • (1978) Int J Cancer Journal international du cancer , vol.22 , Issue.6 , pp. 728-733
    • Wu, M.C.1    Arimura, G.K.2    Yunis, A.A.3
  • 53
    • 33847323097 scopus 로고    scopus 로고
    • Pharmacological and clinical evaluation of l-asparaginase in the treatment of leukemia
    • PID: 17011787
    • Narta UK, Kanwar SS, Azmi W (2007) Pharmacological and clinical evaluation of l-asparaginase in the treatment of leukemia. Crit Rev Oncol Hematol 61(3):208–221. doi:10.1016/j.critrevonc.2006.07.009
    • (2007) Crit Rev Oncol Hematol , vol.61 , Issue.3 , pp. 208-221
    • Narta, U.K.1    Kanwar, S.S.2    Azmi, W.3
  • 54
    • 18644364984 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future
    • PID: 15828851, COI: 1:CAS:528:DC%2BD2MXltlGmsbw%3D
    • Avramis VI, Panosyan EH (2005) Pharmacokinetic/pharmacodynamic relationships of asparaginase formulations: the past, the present and recommendations for the future. Clin Pharmacokinet 44(4):367–393. doi:10.2165/00003088-200544040-00003
    • (2005) Clin Pharmacokinet , vol.44 , Issue.4 , pp. 367-393
    • Avramis, V.I.1    Panosyan, E.H.2
  • 55
    • 0019293446 scopus 로고
    • Phase II study of l-asparaginase in the treatment of pancreatic carcinoma
    • PID: 7471124, COI: 1:STN:280:DyaL3M7jsFKmtg%3D%3D
    • Lessner HE, Valenstein S, Kaplan R, DeSimone P, Yunis A (1980) Phase II study of l-asparaginase in the treatment of pancreatic carcinoma. Cancer Treat Rep 64(12):1359–1361
    • (1980) Cancer Treat Rep , vol.64 , Issue.12 , pp. 1359-1361
    • Lessner, H.E.1    Valenstein, S.2    Kaplan, R.3    DeSimone, P.4    Yunis, A.5
  • 56
    • 34249803312 scopus 로고    scopus 로고
    • Survival after treatment with phenylacetate and benzoate for urea-cycle disorders
    • PID: 17538087, COI: 1:CAS:528:DC%2BD2sXmtVKku7o%3D
    • Enns GM, Berry SA, Berry GT, Rhead WJ, Brusilow SW, Hamosh A (2007) Survival after treatment with phenylacetate and benzoate for urea-cycle disorders. N Engl J Med 356(22):2282–2292. doi:10.1056/NEJMoa066596
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2282-2292
    • Enns, G.M.1    Berry, S.A.2    Berry, G.T.3    Rhead, W.J.4    Brusilow, S.W.5    Hamosh, A.6
  • 59
    • 84867036906 scopus 로고    scopus 로고
    • Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents
    • PID: 22935578, COI: 1:CAS:528:DC%2BC38XhslSktb%2FJ
    • Ploessl K, Wang L, Lieberman BP, Qu W, Kung HF (2012) Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents. J Nucl Med 53(10):1616–1624. doi:10.2967/jnumed.111.101279
    • (2012) J Nucl Med , vol.53 , Issue.10 , pp. 1616-1624
    • Ploessl, K.1    Wang, L.2    Lieberman, B.P.3    Qu, W.4    Kung, H.F.5


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