Suppression of pancreatic beta cell apoptosis by Danzhi Jiangtang capsule contributes to the attenuation of type 1 diabetes in rats

BMC Complementary and Alternative Medicine

Volumn 16, Issue 1, 2016, Pages

  Zheng, Shuguo ^a   Zhao, Mengqiu ^a   Wu, Yuanjie ^b   Wang, Zheng ^b   Ren, Younan ^a  

^a WANNAN MEDICAL COLLEGE   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Danzhi Jiangtang capsule; Diabetes; Pancreatic beta cells; Pancreatic duodenal homeobox 1

Indexed keywords

CASPASE 3; CASPASE 9; DANZHI JIANGTANG; GLUCOSE; INSULIN; MALONALDEHYDE; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CAPSULE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; UPREGULATION; WEIGHT GAIN; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DRUG EFFECTS; MEDICINAL PLANT; PATHOLOGY; WISTAR RAT;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DRUGS, CHINESE HERBAL; INSULIN-SECRETING CELLS; MALE; PLANTS, MEDICINAL; RATS; RATS, WISTAR;

EID: 84956583089     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-016-0993-4     Document Type: Article

References (33)

1. Amati F, Dubé JJ, Coen PM, Stefanovic-Racic M, Toledo FGS, Goodpaster BH. Physical inactivity and obesity underlie the insulin resistance of aging. Diabetes Care. 2009;32:1547-9.
2. Kirino Y, Sato Y, Kamimoto T, Kawazoe K, Minakuchi K. Altered dipeptidyl peptidase-4 activity during the progression of hyperinsulinemic obesity and islet atrophy in spontaneously late-stage type 2 diabetic rats. Am J Physiol Endocrinol Metab. 2011;300:E372-9.
3. Leahy JL. Bonner-Weir S. Weir GC β-cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose induced insulin secretion Diabetes Care. 1992;15:442-55.
4. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20.
5. Zhang QL, Xue YM, Zhu B, Li J, Sha JP, Li SJ. High glucose induces INS-1 cell apoptosis by activating nuclear factor-ΚB. J South Med Univ. 2010;30:2307-9.
6. Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, et al. Glucose induces β-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes. 2001;50:1683-90.
7. Wang Y, Gao L, Li Y, Chen H, Sun ZL. Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis. Int J Mol Sci. 2011;12:1569-80.
8. Jurgens CA, Toukatly MN, Fligner CL, Udayasankar J, Subramanian SL, Zraika S, et al. β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol. 2011;178:2632-40.
9. Butler AE, Janson J, Bonner-Weir S, Rizel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-10.
10. Fang ZH, Liu Y, Bao TT, Ni YQ, Liu J, Shi GB, et al. Effect of Danzhi Jiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions. World J Gastroenterol. 2013;19:2963-8.
11. Guo CL, Fang CH, Jiang T, Yang H. Danzhi Jiangtang capsule in therapy of rats with diabetic nephropathy. J Wannan Med Coll (Chin). 2014;33:5-8.
12. Niu YF, Fang ZH. Clinical study of the improving effect of Danzhi Jiangtang capsule on pancreatic B cell function in elderly patients with type 2 diabetes. J Anhui TCM Coll (Chin). 2008;27:4-6.
13. Wu YJ, Wu YB, Zheng SG, Wang YF, Liu XL, Zhang XJ, et al. Experimental research on establishing a blood glucose fluctuation model in diabetic rats. J South Med Univ (Chin). 2014;34:771-6.
14. Zheng SG, Qian ZY, Sheng L, Wen N. Crocetin attenuates atherosclesosis in hyperlipidemic rabbits through inhibition of LDL oxidation. J Cardiovasc Pharmacol. 2006;47:70-6.
15. Qiang GF, Zhang L, Yang XY, Xuan Q, Shi LL, Zhang HA, et al. Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes. Eur J Pharmacol. 2012;685:156-64.
16. Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, et al. Mechanisms of β-cell death in type 2 diabetes. Diabetes. 2005;54:S108-13.
17. Robertson RP, Harmon J, Tran POT, Poitout V. β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 2004;53:S119-24.
18. Liu HZ, Liu J, Bao TT, Fang ZH. Effects of Danzhi Jiangtang capsule on B-cell function of pancreatic islet in type 2 diabetes. J of Anhui TCM Coll (Chin). 2007;26:5-7.
19. Leibowitz G, Bachar E, Shaked M, Sinai A, Ketzinel-Gilad M, Kaiser N. Glucose regulation of β-cell stress in type 2 diabetes. Diabetes Obes Metab. 2010;12(S2):66-75.
20. Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996;20:463-6.
21. Wali JA, Rondas D, Mckenzie MD, Zhao Y, Elkerbout L, Fynch S, et al. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death Dis. 2014;13:e1124.
22. Fujimoto K, Polonsky KS. Pdx1 and other factors that regulate pancreatic beta-cell survival. Diabetes Obes Metab. 2009;11(S4):30-7.
23. Ren CJ, Zhang Y, Cui WZ, Mu ZM. Progress in the role of oxidative stress in the pathogenesis of type 2 diabetes. Sheng Li Xue Bao (Chin). 2013;65:664-73.
24. Dziegielewska-Gesiak S, Wysocka E, Michalak S, Nowakowska-Zajdel E, Kokot T, Muc-Wierzgon M. Role of lipid peroxidation products, plasma total antioxidant status, and Cu-Zn-superoxide dismutase activity as biomarkers of oxidative stress in elderly prediabetics. Oxid Med Cell Longev. 2014;2014:987303.
25. Kvansakul M, Hinds MG. The Bcl-2 family: structure, interactions and targets for drug discovery. Apoptosis. 2014;20:136-50.
26. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med. 2003;7:249-57.
27. Bie PF, Jin YJ, Dong CX, An JH, Wang GH, Han HJ. The anti-oxidant and anti-aging effect of dodder. J Jilin Med Coll (Chin). 2012;33:332-5.
28. Yang J, Kim JS, Sa YJ, Kim MO, Jeong HJ, Yu CY, et al. Antioxidant, antibacterial and aα-glucosidase inhibitory activities of different extracts of Cortex Moutan. Afr J Biothehnol. 2011;10:9438-44.
29. Yuan BG, He QL, Yin DD, Miao F, Zhou L. Antioxidant activities of Rehmannia glutinosa extracts. J Northwest A& F Univ (Nat Sci Ed) (Chin). 2011;39:137-45.
30. Fang ZH, Ni YQ. Intervention effect of Danzhijiangtang Capsule on vascular endothelium injury induced by oxidative stress in type two diabetes mellitus. J Clin Rational Drug Use (Chin). 2011;4:27-8.
31. Wu YJ, Fang ZH, Zheng SG, Wu YB, Wang Z, Lv MA. ffect of Danzhi Jtiangtang Cpsule combined exercise on the protein expression of NADPH oxidase p22phox in pancreatic tissues of diabetic rats. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chin). 2013;33:641-5.
32. Wu YJ, Fang ZH, Zheng SG, Wu YB, Lv MA, Wang Z, et al. Effects of Danzhi Jiangtang capsule combined exercise on pancreatic oxidative stress and islet β-cell function in diabetic rats. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chin). 2012;32:1531-4.
33. Yuan HP, Lu YG, Huang XQ, He QH, Man Y, Zhou YS, et al. Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. FEBS J. 2010;277:5061-71.