Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells

FEBS Journal

Volumn 277, Issue 24, 2010, Pages 5061-5071

  Yuan, Huiping ^a   Lu, Yonggang ^a   Huang, Xiuqing ^a   He, Qinghua ^a   Man, Yong ^a   Zhou, Yingsheng ^a   Wang, Shu ^a   Li, Jian ^a  

^a Chinese Academy of Medical Sciences   (China)

Author keywords

apoptosis; glucose; NADPH oxidase 2; NIT 1 cells; reactive oxygen species

Indexed keywords

GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REPRESSION; GENE TRANSLOCATION; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 78650023333     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07911.x     Document Type: Article

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