Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

Nature Communications

Volumn 7, Issue , 2016, Pages

  Nassour, Joe ^a,e   Martien, Sébastien ^a   Martin, Nathalie ^a   Deruy, Emeric ^a   Tomellini, Elisa ^a,f   Malaquin, Nicolas ^a,g   Bouali, Fatima ^a   Sabatier, Laure ^b   Wernert, Nicolas ^c   Pinte, Sébastien ^a,d   Gilson, Eric ^d   Pourtier, Albin ^a   Pluquet, Olivier ^a   Abbadie, Corinne ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^f INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^g CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P16; RETINOBLASTOMA PROTEIN; XRCC1 PROTEIN; DNA BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1;

AGING; CARCINOGEN; CELLS AND CELL COMPONENTS; DNA; GENE EXPRESSION; GENETIC ANALYSIS; SENESCENCE;

AGED; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL AGING; CELL CYCLE ARREST; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; EPITHELIUM CELL; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; NORMAL HUMAN; OXIDATIVE STRESS; PRECANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA BREAK; SKIN FIBROBLAST; TELOMERE SHORTENING; UPREGULATION; CYTOLOGY; DNA DAMAGE; GENETICS; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY;

CELL AGING; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EPITHELIAL CELLS; HUMANS; NEOPLASMS; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84956476970     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10399     Document Type: Article

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