Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells

International Journal of Radiation Oncology Biology Physics

Volumn 88, Issue 2, 2014, Pages 385-394

  Azad, Arun ^a,b   Bukczynska, Patricia ^a   Jackson, Susan ^a   Haput, Ygal ^a,b   Cullinane, Carleen ^a,b   McArthur, Grant A ^a,b   Solomon, Benjamin ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATION TREATMENTS; CYTOKINE SECRETIONS; DNA DOUBLE-STRAND BREAKS; DNA-DEPENDENT PROTEIN KINASE; METHODS AND MATERIALS; NON SMALL CELL LUNG CANCER; PHOSPHATIDYLINOSITOL; TARGET OF RAPAMYCIN;

BIOLOGICAL MATERIALS; CELL DEATH; ENZYMES; IONIZING RADIATION; PHOSPHATES; PROTEINS; RADIATION EFFECTS;

DNA;

ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; DACTOLISIB; DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; KU 57788; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P21; RUCAPARIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SENESCENCE; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; CELL AGING; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; G2 PHASE; HISTONES; IMIDAZOLES; INDOLES; KI-67 ANTIGEN; MICE; MICE, NUDE; MORPHOLINES; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; QUINOLINES; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891849619     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.10.043     Document Type: Article

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