메뉴 건너뛰기




Volumn 30, Issue 2, 2015, Pages 124-141

Comprehensive review on kisspeptin and its role in reproductive disorders

Author keywords

Fertility; Gonadotrophins; Gonadotropin releasing hormone; Hypothalamus; Kisspeptins

Indexed keywords


EID: 84955507487     PISSN: 2093596X     EISSN: 20935978     Source Type: Journal    
DOI: 10.3803/EnM.2015.30.2.124     Document Type: Review
Times cited : (134)

References (173)
  • 4
    • 57849161861 scopus 로고    scopus 로고
    • From KISS1 to kisspeptins: an historical perspective and suggested nomenclature
    • Gottsch ML, Clifton DK, Steiner RA. From KISS1 to kisspeptins: an historical perspective and suggested nomenclature. Peptides 2009;30:4-9.
    • (2009) Peptides , vol.30 , pp. 4-9
    • Gottsch, M.L.1    Clifton, D.K.2    Steiner, R.A.3
  • 7
    • 50449087725 scopus 로고    scopus 로고
    • Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels
    • Liu X, Lee K, Herbison AE. Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 2008;149:4605-14.
    • (2008) Endocrinology , vol.149 , pp. 4605-4614
    • Liu, X.1    Lee, K.2    Herbison, A.E.3
  • 8
    • 62749203684 scopus 로고    scopus 로고
    • Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons
    • Constantin S, Caligioni CS, Stojilkovic S, Wray S. Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. Endocrinology 2009;150:1400-12.
    • (2009) Endocrinology , vol.150 , pp. 1400-1412
    • Constantin, S.1    Caligioni, C.S.2    Stojilkovic, S.3    Wray, S.4
  • 12
    • 34447115135 scopus 로고    scopus 로고
    • Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
    • Rometo AM, Krajewski SJ, Voytko ML, Rance NE. Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 2007;92:2744-50.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2744-2750
    • Rometo, A.M.1    Krajewski, S.J.2    Voytko, M.L.3    Rance, N.E.4
  • 13
    • 33751538038 scopus 로고    scopus 로고
    • Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons
    • Clarkson J, Herbison AE. Postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonadotropin-releasing hormone neurons. Endocrinology 2006;147:5817-25.
    • (2006) Endocrinology , vol.147 , pp. 5817-5825
    • Clarkson, J.1    Herbison, A.E.2
  • 17
    • 77950926407 scopus 로고    scopus 로고
    • Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones
    • Bakker J, Pierman S, Gonzalez-Martinez D. Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Horm Behav 2010;57:390-5.
    • (2010) Horm Behav , vol.57 , pp. 390-395
    • Bakker, J.1    Pierman, S.2    Gonzalez-Martinez, D.3
  • 18
    • 67649665605 scopus 로고    scopus 로고
    • Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset
    • Clarkson J, Boon WC, Simpson ER, Herbison AE. Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology 2009;150:3214-20.
    • (2009) Endocrinology , vol.150 , pp. 3214-3220
    • Clarkson, J.1    Boon, W.C.2    Simpson, E.R.3    Herbison, A.E.4
  • 19
    • 84860902677 scopus 로고    scopus 로고
    • Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse
    • Clarkson J, Shamas S, Mallinson S, Herbison AE. Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse. J Neuroendocrinol 2012;24:907-15.
    • (2012) J Neuroendocrinol , vol.24 , pp. 907-915
    • Clarkson, J.1    Shamas, S.2    Mallinson, S.3    Herbison, A.E.4
  • 20
    • 0028144394 scopus 로고
    • Topography of neurons expressing luteinizing hormone-releasing hormone gene transcripts in the human hypothalamus and basal forebrain
    • Rance NE, Young WS 3rd, McMullen NT. Topography of neurons expressing luteinizing hormone-releasing hormone gene transcripts in the human hypothalamus and basal forebrain. J Comp Neurol 1994;339:573-86.
    • (1994) J Comp Neurol , vol.339 , pp. 573-586
    • Rance, N.E.1    Young, W.S.2    McMullen, N.T.3
  • 21
    • 47949125934 scopus 로고    scopus 로고
    • Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals
    • d'Anglemont de Tassigny X, Fagg LA, Carlton MB, Colledge WH. Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals. Endocrinology 2008;149:3926-32.
    • (2008) Endocrinology , vol.149 , pp. 3926-3932
    • d'Anglemont de Tassigny, X.1    Fagg, L.A.2    Carlton, M.B.3    Colledge, W.H.4
  • 22
    • 73649131642 scopus 로고    scopus 로고
    • Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons
    • Herbison AE, de Tassigny X, Doran J, Colledge WH. Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 2010;151:312-21.
    • (2010) Endocrinology , vol.151 , pp. 312-321
    • Herbison, A.E.1    de Tassigny, X.2    Doran, J.3    Colledge, W.H.4
  • 24
    • 69249219124 scopus 로고    scopus 로고
    • Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines
    • Novaira HJ, Ng Y, Wolfe A, Radovick S. Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol 2009;311:126-34.
    • (2009) Mol Cell Endocrinol , vol.311 , pp. 126-134
    • Novaira, H.J.1    Ng, Y.2    Wolfe, A.3    Radovick, S.4
  • 29
    • 80053141024 scopus 로고    scopus 로고
    • Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone (GnRH) interaction in the median eminence of female rats: implication of axo-axonal regulation of GnRH release
    • Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI, Tsukamura H. Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone (GnRH) interaction in the median eminence of female rats: implication of axo-axonal regulation of GnRH release. J Neuroendocrinol 2011;23:863-70.
    • (2011) J Neuroendocrinol , vol.23 , pp. 863-870
    • Uenoyama, Y.1    Inoue, N.2    Pheng, V.3    Homma, T.4    Takase, K.5    Yamada, S.6    Ajiki, K.7    Ichikawa, M.8    Okamura, H.9    Maeda, K.I.10    Tsukamura, H.11
  • 31
    • 84856104543 scopus 로고    scopus 로고
    • Developmental changes in GnRH release in response to kisspeptin agonist and antagonist in female rhesus monkeys (Macaca mulatta): implication for the mechanism of puberty
    • Guerriero KA, Keen KL, Millar RP, Terasawa E. Developmental changes in GnRH release in response to kisspeptin agonist and antagonist in female rhesus monkeys (Macaca mulatta): implication for the mechanism of puberty. Endocrinology 2012;153:825-36.
    • (2012) Endocrinology , vol.153 , pp. 825-836
    • Guerriero, K.A.1    Keen, K.L.2    Millar, R.P.3    Terasawa, E.4
  • 34
    • 29644447614 scopus 로고    scopus 로고
    • Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism
    • Lanfranco F, Gromoll J, von Eckardstein S, Herding EM, Nieschlag E, Simoni M. Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol 2005;153:845-52.
    • (2005) Eur J Endocrinol , vol.153 , pp. 845-852
    • Lanfranco, F.1    Gromoll, J.2    von Eckardstein, S.3    Herding, E.M.4    Nieschlag, E.5    Simoni, M.6
  • 37
    • 33947493910 scopus 로고    scopus 로고
    • Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54
    • Tenenbaum-Rakover Y, Commenges-Ducos M, Iovane A, Aumas C, Admoni O, de Roux N. Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54. J Clin Endocrinol Metab 2007;92:1137-44.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1137-1144
    • Tenenbaum-Rakover, Y.1    Commenges-Ducos, M.2    Iovane, A.3    Aumas, C.4    Admoni, O.5    de Roux, N.6
  • 38
    • 84864371825 scopus 로고    scopus 로고
    • A novel severe N-terminal splice site KISS1R gene mutation causes hypogonadotropic hypogonadism but enables a normal development of neonatal external genitalia
    • Breuer O, Abdulhadi-Atwan M, Zeligson S, Fridman H, Renbaum P, Levy-Lahad E, Zangen DH. A novel severe N-terminal splice site KISS1R gene mutation causes hypogonadotropic hypogonadism but enables a normal development of neonatal external genitalia. Eur J Endocrinol 2012;167:209-16.
    • (2012) Eur J Endocrinol , vol.167 , pp. 209-216
    • Breuer, O.1    Abdulhadi-Atwan, M.2    Zeligson, S.3    Fridman, H.4    Renbaum, P.5    Levy-Lahad, E.6    Zangen, D.H.7
  • 44
    • 70949094457 scopus 로고    scopus 로고
    • Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice
    • Chan YM, Broder-Fingert S, Wong KM, Seminara SB. Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. J Neuroendocrinol 2009;21:1015-23.
    • (2009) J Neuroendocrinol , vol.21 , pp. 1015-1023
    • Chan, Y.M.1    Broder-Fingert, S.2    Wong, K.M.3    Seminara, S.B.4
  • 47
    • 77957737153 scopus 로고    scopus 로고
    • KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect
    • Ko JM, Lee HS, Hwang JS. KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect. Endocr J 2010;57:701-9.
    • (2010) Endocr J , vol.57 , pp. 701-709
    • Ko, J.M.1    Lee, H.S.2    Hwang, J.S.3
  • 50
    • 84861637272 scopus 로고    scopus 로고
    • Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression
    • Demirbilek H, Gonc EN, Ozon A, Alikasifoglu A, Kandemir N. Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression. J Pediatr Endocrinol Metab 2012;25:313-6.
    • (2012) J Pediatr Endocrinol Metab , vol.25 , pp. 313-316
    • Demirbilek, H.1    Gonc, E.N.2    Ozon, A.3    Alikasifoglu, A.4    Kandemir, N.5
  • 51
  • 55
    • 33847008349 scopus 로고    scopus 로고
    • KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season
    • Smith JT, Clay CM, Caraty A, Clarke IJ. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology 2007;148:1150-7.
    • (2007) Endocrinology , vol.148 , pp. 1150-1157
    • Smith, J.T.1    Clay, C.M.2    Caraty, A.3    Clarke, I.J.4
  • 57
    • 84870253755 scopus 로고    scopus 로고
    • Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor
    • Li Q, Roa A, Clarke IJ, Smith JT. Seasonal variation in the gonadotropin-releasing hormone response to kisspeptin in sheep: possible kisspeptin regulation of the kisspeptin receptor. Neuroendocrinology 2012;96:212-21.
    • (2012) Neuroendocrinology , vol.96 , pp. 212-221
    • Li, Q.1    Roa, A.2    Clarke, I.J.3    Smith, J.T.4
  • 58
    • 84904577193 scopus 로고    scopus 로고
    • Photoperiodic co-regulation of kisseptin, neurokinin B and dynorphin in the hypothalamus of a seasonal rodent
    • Bartzen-Sprauer J, Klosen P, Ciofi P, Mikkelsen JD, Simonneaux V. Photoperiodic co-regulation of kisseptin, neurokinin B and dynorphin in the hypothalamus of a seasonal rodent. J Neuroendocrinol 2014;26:510-20.
    • (2014) J Neuroendocrinol , vol.26 , pp. 510-520
    • Bartzen-Sprauer, J.1    Klosen, P.2    Ciofi, P.3    Mikkelsen, J.D.4    Simonneaux, V.5
  • 59
    • 84902468521 scopus 로고    scopus 로고
    • Effects of pinealectomy and short day lengths on reproduction and neuronal RFRP-3, kisspeptin, and GnRH in female Turkish hamsters
    • Piekarski DJ, Jarjisian SG, Perez L, Ahmad H, Dhawan N, Zucker I, Kriegsfeld LJ. Effects of pinealectomy and short day lengths on reproduction and neuronal RFRP-3, kisspeptin, and GnRH in female Turkish hamsters. J Biol Rhythms 2014;29:181-91.
    • (2014) J Biol Rhythms , vol.29 , pp. 181-191
    • Piekarski, D.J.1    Jarjisian, S.G.2    Perez, L.3    Ahmad, H.4    Dhawan, N.5    Zucker, I.6    Kriegsfeld, L.J.7
  • 62
    • 0019219941 scopus 로고
    • Opiate activity and receptor selectivity of dynorphin1-13 and related peptides
    • Wuster M, Schulz R, Herz A. Opiate activity and receptor selectivity of dynorphin1-13 and related peptides. Neurosci Lett 1980;20:79-83.
    • (1980) Neurosci Lett , vol.20 , pp. 79-83
    • Wuster, M.1    Schulz, R.2    Herz, A.3
  • 63
    • 2542422831 scopus 로고    scopus 로고
    • Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep
    • Goodman RL, Coolen LM, Anderson GM, Hardy SL, Valent M, Connors JM, Fitzgerald ME, Lehman MN. Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep. Endocrinology 2004;145:2959-67.
    • (2004) Endocrinology , vol.145 , pp. 2959-2967
    • Goodman, R.L.1    Coolen, L.M.2    Anderson, G.M.3    Hardy, S.L.4    Valent, M.5    Connors, J.M.6    Fitzgerald, M.E.7    Lehman, M.N.8
  • 65
    • 33748470566 scopus 로고    scopus 로고
    • Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus
    • Burke MC, Letts PA, Krajewski SJ, Rance NE. Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol 2006;498:712-26.
    • (2006) J Comp Neurol , vol.498 , pp. 712-726
    • Burke, M.C.1    Letts, P.A.2    Krajewski, S.J.3    Rance, N.E.4
  • 66
    • 70349342734 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    • Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA. Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 2009;29:11859-66.
    • (2009) J Neurosci , vol.29 , pp. 11859-11866
    • Navarro, V.M.1    Gottsch, M.L.2    Chavkin, C.3    Okamura, H.4    Clifton, D.K.5    Steiner, R.A.6
  • 67
    • 77649123886 scopus 로고    scopus 로고
    • Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    • Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 2010;30:3124-32.
    • (2010) J Neurosci , vol.30 , pp. 3124-3132
    • Wakabayashi, Y.1    Nakada, T.2    Murata, K.3    Ohkura, S.4    Mogi, K.5    Navarro, V.M.6    Clifton, D.K.7    Mori, Y.8    Tsukamura, H.9    Maeda, K.10    Steiner, R.A.11    Okamura, H.12
  • 68
    • 57849167037 scopus 로고    scopus 로고
    • Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback
    • Rance NE. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides 2009;30:111-22.
    • (2009) Peptides , vol.30 , pp. 111-122
    • Rance, N.E.1
  • 70
    • 77954895859 scopus 로고    scopus 로고
    • Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    • Lehman MN, Coolen LM, Goodman RL. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 2010;151:3479-89.
    • (2010) Endocrinology , vol.151 , pp. 3479-3489
    • Lehman, M.N.1    Coolen, L.M.2    Goodman, R.L.3
  • 71
    • 22644439726 scopus 로고    scopus 로고
    • Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence
    • Krajewski SJ, Anderson MJ, Iles-Shih L, Chen KJ, Urbanski HF, Rance NE. Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J Comp Neurol 2005;489:372-86.
    • (2005) J Comp Neurol , vol.489 , pp. 372-386
    • Krajewski, S.J.1    Anderson, M.J.2    Iles-Shih, L.3    Chen, K.J.4    Urbanski, H.F.5    Rance, N.E.6
  • 72
    • 83655161318 scopus 로고    scopus 로고
    • Morphological evidence for direct interaction between kisspeptin and gonadotropin-releasing hormone neurons at the median eminence of the male goat: an immunoelectron microscopic study
    • Matsuyama S, Ohkura S, Mogi K, Wakabayashi Y, Mori Y, Tsukamura H, Maeda K, Ichikawa M, Okamura H. Morphological evidence for direct interaction between kisspeptin and gonadotropin-releasing hormone neurons at the median eminence of the male goat: an immunoelectron microscopic study. Neuroendocrinology 2011;94:323-32.
    • (2011) Neuroendocrinology , vol.94 , pp. 323-332
    • Matsuyama, S.1    Ohkura, S.2    Mogi, K.3    Wakabayashi, Y.4    Mori, Y.5    Tsukamura, H.6    Maeda, K.7    Ichikawa, M.8    Okamura, H.9
  • 73
    • 0025672623 scopus 로고
    • Kappa-opioid receptor involvement in the regulation of pulsatile luteinizing hormone release during early pregnancy in the rat
    • Gallo RV. Kappa-opioid receptor involvement in the regulation of pulsatile luteinizing hormone release during early pregnancy in the rat. J Neuroendocrinol 1990;2:685-91.
    • (1990) J Neuroendocrinol , vol.2 , pp. 685-691
    • Gallo, R.V.1
  • 74
    • 84904725144 scopus 로고    scopus 로고
    • A role for neurokinin B in pulsatile GnRH secretion in the ewe
    • Goodman RL, Coolen LM, Lehman MN. A role for neurokinin B in pulsatile GnRH secretion in the ewe. Neuroendocrinology 2014;99:18-32.
    • (2014) Neuroendocrinology , vol.99 , pp. 18-32
    • Goodman, R.L.1    Coolen, L.M.2    Lehman, M.N.3
  • 75
    • 0030879711 scopus 로고    scopus 로고
    • Presence of mu and kappa opioid receptor mRNAs in galanin but not in GnRH neurons in the female rat
    • Mitchell V, Prevot V, Jennes L, Aubert JP, Croix D, Beauvillain JC. Presence of mu and kappa opioid receptor mRNAs in galanin but not in GnRH neurons in the female rat. Neuroreport 1997;8:3167-72.
    • (1997) Neuroreport , vol.8 , pp. 3167-3172
    • Mitchell, V.1    Prevot, V.2    Jennes, L.3    Aubert, J.P.4    Croix, D.5    Beauvillain, J.C.6
  • 76
    • 0030984991 scopus 로고    scopus 로고
    • Dual label in situ hybridization studies provide evidence that luteinizing hormone-releasing hormone neurons do not synthesize messenger ribonucleic acid for mu, kappa, or delta opiate receptors
    • Sannella MI, Petersen SL. Dual label in situ hybridization studies provide evidence that luteinizing hormone-releasing hormone neurons do not synthesize messenger ribonucleic acid for mu, kappa, or delta opiate receptors. Endocrinology 1997;138:1667-72.
    • (1997) Endocrinology , vol.138 , pp. 1667-1672
    • Sannella, M.I.1    Petersen, S.L.2
  • 77
    • 5444220724 scopus 로고    scopus 로고
    • Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus
    • Sandoval-Guzman T, Rance NE. Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. Brain Res 2004;1026:307-12.
    • (2004) Brain Res , vol.1026 , pp. 307-312
    • Sandoval-Guzman, T.1    Rance, N.E.2
  • 79
    • 77956043908 scopus 로고    scopus 로고
    • Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus
    • Ramaswamy S, Seminara SB, Ali B, Ciofi P, Amin NA, Plant TM. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology 2010;151:4494-503.
    • (2010) Endocrinology , vol.151 , pp. 4494-4503
    • Ramaswamy, S.1    Seminara, S.B.2    Ali, B.3    Ciofi, P.4    Amin, N.A.5    Plant, T.M.6
  • 80
    • 81355149648 scopus 로고    scopus 로고
    • Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor
    • Ramaswamy S, Seminara SB, Plant TM. Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor. Neuroendocrinology 2011;94:237-45.
    • (2011) Neuroendocrinology , vol.94 , pp. 237-245
    • Ramaswamy, S.1    Seminara, S.B.2    Plant, T.M.3
  • 82
    • 84904754660 scopus 로고    scopus 로고
    • The role of neurokinin B signalling in reproductive neuroendocrinology
    • Grachev P, Millar RP, O'Byrne KT. The role of neurokinin B signalling in reproductive neuroendocrinology. Neuroendocrinology 2014;99:7-17.
    • (2014) Neuroendocrinology , vol.99 , pp. 7-17
    • Grachev, P.1    Millar, R.P.2    O'Byrne, K.T.3
  • 87
    • 84866761591 scopus 로고    scopus 로고
    • Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept
    • Hrabovszky E, Sipos MT, Molnar CS, Ciofi P, Borsay BA, Gergely P, Herczeg L, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z. Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept. Endocrinology 2012;153:4978-89.
    • (2012) Endocrinology , vol.153 , pp. 4978-4989
    • Hrabovszky, E.1    Sipos, M.T.2    Molnar, C.S.3    Ciofi, P.4    Borsay, B.A.5    Gergely, P.6    Herczeg, L.7    Bloom, S.R.8    Ghatei, M.A.9    Dhillo, W.S.10    Liposits, Z.11
  • 88
    • 84880655267 scopus 로고    scopus 로고
    • Cocaine-and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females
    • True C, Verma S, Grove KL, Smith MS. Cocaine-and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females. Endocrinology 2013;154:2821-32.
    • (2013) Endocrinology , vol.154 , pp. 2821-2832
    • True, C.1    Verma, S.2    Grove, K.L.3    Smith, M.S.4
  • 89
    • 0038517910 scopus 로고    scopus 로고
    • Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta
    • Couse JF, Yates MM, Walker VR, Korach KS. Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Mol Endocrinol 2003;17:1039-53.
    • (2003) Mol Endocrinol , vol.17 , pp. 1039-1053
    • Couse, J.F.1    Yates, M.M.2    Walker, V.R.3    Korach, K.S.4
  • 91
    • 0027091606 scopus 로고
    • Immunocytochemical identification of oestrogen receptors in preoptic neurones containing calcitonin gene-related peptide in the male and female rat
    • Herbison AE, Theodosis DT. Immunocytochemical identification of oestrogen receptors in preoptic neurones containing calcitonin gene-related peptide in the male and female rat. Neuroendocrinology 1992;56:761-4.
    • (1992) Neuroendocrinology , vol.56 , pp. 761-764
    • Herbison, A.E.1    Theodosis, D.T.2
  • 92
    • 33745787320 scopus 로고    scopus 로고
    • Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge
    • Smith JT, Popa SM, Clifton DK, Hoffman GE, Steiner RA. Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci 2006;26:6687-94.
    • (2006) J Neurosci , vol.26 , pp. 6687-6694
    • Smith, J.T.1    Popa, S.M.2    Clifton, D.K.3    Hoffman, G.E.4    Steiner, R.A.5
  • 93
    • 2942750179 scopus 로고    scopus 로고
    • Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
    • Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki T. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 2004;320:383-8.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 383-388
    • Matsui, H.1    Takatsu, Y.2    Kumano, S.3    Matsumoto, H.4    Ohtaki, T.5
  • 97
    • 52049083005 scopus 로고    scopus 로고
    • Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge
    • Clarkson J, d'Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE. Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 2008;28:8691-7.
    • (2008) J Neurosci , vol.28 , pp. 8691-8697
    • Clarkson, J.1    d'Anglemont de Tassigny, X.2    Moreno, A.S.3    Colledge, W.H.4    Herbison, A.E.5
  • 98
    • 35948986402 scopus 로고    scopus 로고
    • The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
    • Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA. The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci 2007;27:12088-95.
    • (2007) J Neurosci , vol.27 , pp. 12088-12095
    • Dungan, H.M.1    Gottsch, M.L.2    Zeng, H.3    Gragerov, A.4    Bergmann, J.E.5    Vassilatis, D.K.6    Clifton, D.K.7    Steiner, R.A.8
  • 106
    • 84904318063 scopus 로고    scopus 로고
    • Intratesticular action of kisspeptin in rhesus monkey (Macaca mulatta)
    • Irfan S, Ehmcke J, Wahab F, Shahab M, Schlatt S. Intratesticular action of kisspeptin in rhesus monkey (Macaca mulatta). Andrologia 2014;46:610-7.
    • (2014) Andrologia , vol.46 , pp. 610-617
    • Irfan, S.1    Ehmcke, J.2    Wahab, F.3    Shahab, M.4    Schlatt, S.5
  • 110
    • 84859161979 scopus 로고    scopus 로고
    • Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells
    • Roseweir AK, Katz AA, Millar RP. Kisspeptin-10 inhibits cell migration in vitro via a receptor-GSK3 beta-FAK feedback loop in HTR8SVneo cells. Placenta 2012;33:408-15.
    • (2012) Placenta , vol.33 , pp. 408-415
    • Roseweir, A.K.1    Katz, A.A.2    Millar, R.P.3
  • 111
    • 0037323459 scopus 로고    scopus 로고
    • Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans
    • Horikoshi Y, Matsumoto H, Takatsu Y, Ohtaki T, Kitada C, Usuki S, Fujino M. Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab 2003;88:914-9.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 914-919
    • Horikoshi, Y.1    Matsumoto, H.2    Takatsu, Y.3    Ohtaki, T.4    Kitada, C.5    Usuki, S.6    Fujino, M.7
  • 116
    • 42049102207 scopus 로고    scopus 로고
    • Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates
    • Smets EM, Deurloo KL, Go AT, van Vugt JM, Blankenstein MA, Oudejans CB. Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates. Prenat Diagn 2008;28:299-303.
    • (2008) Prenat Diagn , vol.28 , pp. 299-303
    • Smets, E.M.1    Deurloo, K.L.2    Go, A.T.3    van Vugt, J.M.4    Blankenstein, M.A.5    Oudejans, C.B.6
  • 118
    • 84855357324 scopus 로고    scopus 로고
    • Expression of Kisspeptin and its receptor GPR54 in the first trimester trophoblast of women with recurrent pregnancy loss
    • Park DW, Lee SK, Hong SR, Han AR, Kwak-Kim J, Yang KM. Expression of Kisspeptin and its receptor GPR54 in the first trimester trophoblast of women with recurrent pregnancy loss. Am J Reprod Immunol 2012;67:132-9.
    • (2012) Am J Reprod Immunol , vol.67 , pp. 132-139
    • Park, D.W.1    Lee, S.K.2    Hong, S.R.3    Han, A.R.4    Kwak-Kim, J.5    Yang, K.M.6
  • 119
    • 84863224324 scopus 로고    scopus 로고
    • Association of kisspeptin-10 levels with abortus imminens: a preliminary study
    • Kavvasoglu S, Ozkan ZS, Kumbak B, Simsek M, Ilhan N. Association of kisspeptin-10 levels with abortus imminens: a preliminary study. Arch Gynecol Obstet 2012;285:649-53.
    • (2012) Arch Gynecol Obstet , vol.285 , pp. 649-653
    • Kavvasoglu, S.1    Ozkan, Z.S.2    Kumbak, B.3    Simsek, M.4    Ilhan, N.5
  • 121
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996;12:318-20.
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 128
    • 77953148020 scopus 로고    scopus 로고
    • Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells
    • Backholer K, Smith JT, Rao A, Pereira A, Iqbal J, Ogawa S, Li Q, Clarke IJ. Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 2010;151:2233-43.
    • (2010) Endocrinology , vol.151 , pp. 2233-2243
    • Backholer, K.1    Smith, J.T.2    Rao, A.3    Pereira, A.4    Iqbal, J.5    Ogawa, S.6    Li, Q.7    Clarke, I.J.8
  • 129
    • 71949110404 scopus 로고    scopus 로고
    • Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe
    • Backholer K, Smith J, Clarke IJ. Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology 2009;150:5488-97.
    • (2009) Endocrinology , vol.150 , pp. 5488-5497
    • Backholer, K.1    Smith, J.2    Clarke, I.J.3
  • 130
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-62.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 132
    • 84899485312 scopus 로고    scopus 로고
    • Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone
    • Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci 2014;34:6047-56.
    • (2014) J Neurosci , vol.34 , pp. 6047-6056
    • Martin, C.1    Navarro, V.M.2    Simavli, S.3    Vong, L.4    Carroll, R.S.5    Lowell, B.B.6    Kaiser, U.B.7
  • 133
    • 84902957730 scopus 로고    scopus 로고
    • Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice
    • Evans MC, Rizwan M, Mayer C, Boehm U, Anderson GM. Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. J Neuroendocrinol 2014;26:468-79.
    • (2014) J Neuroendocrinol , vol.26 , pp. 468-479
    • Evans, M.C.1    Rizwan, M.2    Mayer, C.3    Boehm, U.4    Anderson, G.M.5
  • 135
    • 84895520553 scopus 로고    scopus 로고
    • Primate HPT axis response to the peripheral kisspeptin challenge under different time periods of food restriction in monkeys
    • Wahab F, Atika B, Huma T, Shahab M. Primate HPT axis response to the peripheral kisspeptin challenge under different time periods of food restriction in monkeys. Horm Metab Res 2014;46:187-92.
    • (2014) Horm Metab Res , vol.46 , pp. 187-192
    • Wahab, F.1    Atika, B.2    Huma, T.3    Shahab, M.4
  • 139
    • 79961187183 scopus 로고    scopus 로고
    • The role of dysregulated glucagon secretion in type 2 diabetes
    • D'Alessio D. The role of dysregulated glucagon secretion in type 2 diabetes. Diabetes Obes Metab 2011;13 Suppl 1:126-32.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 126-132
    • D'Alessio, D.1
  • 140
    • 3543003513 scopus 로고    scopus 로고
    • The influence of 17beta-oestradiol on corticotrophin-releasing hormone induced suppression of luteinising hormone pulses and the role of CRH in hypoglycaemic stress-induced suppression of pulsatile LH secretion in the female rat
    • Cates PS, Li XF, O'Byrne KT. The influence of 17beta-oestradiol on corticotrophin-releasing hormone induced suppression of luteinising hormone pulses and the role of CRH in hypoglycaemic stress-induced suppression of pulsatile LH secretion in the female rat. Stress 2004;7:113-8.
    • (2004) Stress , vol.7 , pp. 113-118
    • Cates, P.S.1    Li, X.F.2    O'Byrne, K.T.3
  • 141
    • 33745748046 scopus 로고    scopus 로고
    • Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    • Li XF, Bowe JE, Kinsey-Jones JS, Brain SD, Lightman SL, O'Byrne KT. Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat. J Neuroendocrinol 2006;18:602-10.
    • (2006) J Neuroendocrinol , vol.18 , pp. 602-610
    • Li, X.F.1    Bowe, J.E.2    Kinsey-Jones, J.S.3    Brain, S.D.4    Lightman, S.L.5    O'Byrne, K.T.6
  • 142
    • 57749201616 scopus 로고    scopus 로고
    • Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat
    • Kinsey-Jones JS, Li XF, Knox AM, Wilkinson ES, Zhu XL, Chaudhary AA, Milligan SR, Lightman SL, O'Byrne KT. Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat. J Neuroendocrinol 2009;21:20-9.
    • (2009) J Neuroendocrinol , vol.21 , pp. 20-29
    • Kinsey-Jones, J.S.1    Li, X.F.2    Knox, A.M.3    Wilkinson, E.S.4    Zhu, X.L.5    Chaudhary, A.A.6    Milligan, S.R.7    Lightman, S.L.8    O'Byrne, K.T.9
  • 144
    • 0038619013 scopus 로고    scopus 로고
    • Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress
    • He D, Sato I, Kimura F, Akema T. Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress. J Neuroendocrinol 2003;15:559-63.
    • (2003) J Neuroendocrinol , vol.15 , pp. 559-563
    • He, D.1    Sato, I.2    Kimura, F.3    Akema, T.4
  • 145
    • 1642588146 scopus 로고    scopus 로고
    • Inhibitory effects of endotoxin on LH secretion in the ovariectomized monkey are prevented by naloxone but not by an interleukin-1 receptor antagonist
    • Xiao E, Xia-Zhang L, Ferin M. Inhibitory effects of endotoxin on LH secretion in the ovariectomized monkey are prevented by naloxone but not by an interleukin-1 receptor antagonist. Neuroimmunomodulation 2000;7:6-15.
    • (2000) Neuroimmunomodulation , vol.7 , pp. 6-15
    • Xiao, E.1    Xia-Zhang, L.2    Ferin, M.3
  • 155
    • 84864802249 scopus 로고    scopus 로고
    • Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle
    • Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB. Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. J Clin Endocrinol Metab 2012;97:E1458-67.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E1458-E1467
    • Chan, Y.M.1    Butler, J.P.2    Sidhoum, V.F.3    Pinnell, N.E.4    Seminara, S.B.5
  • 158
    • 33645884139 scopus 로고    scopus 로고
    • Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
    • Seminara SB, Dipietro MJ, Ramaswamy S, Crowley WF Jr, Plant TM. Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications. Endocrinology 2006;147:2122-6.
    • (2006) Endocrinology , vol.147 , pp. 2122-2126
    • Seminara, S.B.1    Dipietro, M.J.2    Ramaswamy, S.3    Crowley, W.F.4    Plant, T.M.5
  • 159
    • 84878530524 scopus 로고    scopus 로고
    • Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism
    • George JT, Veldhuis JD, Tena-Sempere M, Millar RP, Anderson RA. Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clin Endocrinol (Oxf) 2013;79:100-4.
    • (2013) Clin Endocrinol (Oxf) , vol.79 , pp. 100-104
    • George, J.T.1    Veldhuis, J.D.2    Tena-Sempere, M.3    Millar, R.P.4    Anderson, R.A.5
  • 160
    • 40049095704 scopus 로고    scopus 로고
    • Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells
    • Kadokawa H, Suzuki S, Hashizume T. Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells. Anim Reprod Sci 2008;105:404-8.
    • (2008) Anim Reprod Sci , vol.105 , pp. 404-408
    • Kadokawa, H.1    Suzuki, S.2    Hashizume, T.3
  • 161
    • 79951936568 scopus 로고    scopus 로고
    • Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms
    • Luque RM, Cordoba-Chacon J, Gahete MD, Navarro VM, Tena-Sempere M, Kineman RD, Castano JP. Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology 2011;152:957-66.
    • (2011) Endocrinology , vol.152 , pp. 957-966
    • Luque, R.M.1    Cordoba-Chacon, J.2    Gahete, M.D.3    Navarro, V.M.4    Tena-Sempere, M.5    Kineman, R.D.6    Castano, J.P.7
  • 162
    • 39749181503 scopus 로고    scopus 로고
    • Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers
    • Kadokawa H, Matsui M, Hayashi K, Matsunaga N, Kawashima C, Shimizu T, Kida K, Miyamoto A. Peripheral administration of kisspeptin-10 increases plasma concentrations of GH as well as LH in prepubertal Holstein heifers. J Endocrinol 2008;196:331-4.
    • (2008) J Endocrinol , vol.196 , pp. 331-334
    • Kadokawa, H.1    Matsui, M.2    Hayashi, K.3    Matsunaga, N.4    Kawashima, C.5    Shimizu, T.6    Kida, K.7    Miyamoto, A.8
  • 164
    • 70349974429 scopus 로고    scopus 로고
    • Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones
    • Ramaswamy S, Gibbs RB, Plant TM. Studies of the localisation of kisspeptin within the pituitary of the rhesus monkey (Macaca mulatta) and the effect of kisspeptin on the release of non-gonadotropic pituitary hormones. J Neuroendocrinol 2009;21:795-804.
    • (2009) J Neuroendocrinol , vol.21 , pp. 795-804
    • Ramaswamy, S.1    Gibbs, R.B.2    Plant, T.M.3
  • 166
    • 0022655435 scopus 로고
    • Hyperprolactinemia alters the frequency and amplitude of pulsatile luteinizing hormone secretion in the ovariectomized rat
    • Cohen-Becker IR, Selmanoff M, Wise PM. Hyperprolactinemia alters the frequency and amplitude of pulsatile luteinizing hormone secretion in the ovariectomized rat. Neuroendocrinology 1986;42:328-33.
    • (1986) Neuroendocrinology , vol.42 , pp. 328-333
    • Cohen-Becker, I.R.1    Selmanoff, M.2    Wise, P.M.3
  • 168
    • 34548083738 scopus 로고    scopus 로고
    • Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice
    • Grattan DR, Jasoni CL, Liu X, Anderson GM, Herbison AE. Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology 2007;148:4344-51.
    • (2007) Endocrinology , vol.148 , pp. 4344-4351
    • Grattan, D.R.1    Jasoni, C.L.2    Liu, X.3    Anderson, G.M.4    Herbison, A.E.5
  • 169
    • 79951656002 scopus 로고    scopus 로고
    • Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility
    • Kokay IC, Petersen SL, Grattan DR. Identification of prolactin-sensitive GABA and kisspeptin neurons in regions of the rat hypothalamus involved in the control of fertility. Endocrinology 2011;152:526-35.
    • (2011) Endocrinology , vol.152 , pp. 526-535
    • Kokay, I.C.1    Petersen, S.L.2    Grattan, D.R.3
  • 172
    • 33645552273 scopus 로고    scopus 로고
    • The science behind 25 years of ovarian stimulation for in vitro fertilization
    • Macklon NS, Stouffer RL, Giudice LC, Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev 2006;27:170-207.
    • (2006) Endocr Rev , vol.27 , pp. 170-207
    • Macklon, N.S.1    Stouffer, R.L.2    Giudice, L.C.3    Fauser, B.C.4
  • 173
    • 84905833732 scopus 로고    scopus 로고
    • Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies
    • MacLean DB, Matsui H, Suri A, Neuwirth R, Colombel M. Sustained exposure to the investigational Kisspeptin analog, TAK-448, down-regulates testosterone into the castration range in healthy males and in patients with prostate cancer: results from two phase 1 studies. J Clin Endocrinol Metab 2014;99:E1445-53.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E1445-E1453
    • MacLean, D.B.1    Matsui, H.2    Suri, A.3    Neuwirth, R.4    Colombel, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.