Kisspeptin restores pulsatile LH secretion in patients with neurokinin B signaling deficiencies: Physiological, pathophysiological and therapeutic implications

Neuroendocrinology

Volumn 97, Issue 2, 2013, Pages 193-202

  Young, Jacques ^a,c   George, Jyothis T ^e   Tello, Javier A ^e,f   Francou, Bruno ^a,b,d   Bouligand, Jerome ^a,b,d   Guiochon Mantel, Anne ^a,b,d   Brailly Tabard, Sylvie ^a,b,d   Anderson, Richard A ^e   Millar, Robert P ^e,g  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c Service d'Endocrinologie et des Maladies de la Reproduction   (France)

^d BICÊTRE HOSPITAL   (France)

^e MRC Reproductive Biology Unit   (United Kingdom)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Deficient NKB signaling; GnRH pulse generation; Hypogonadotropic hypogonadism; Kisspeptin; Kisspeptin 10 infusion; Neurokinin B signaling deficiency; Pulsatile LH secretion

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADORELIN; GONADOTROPIN; INHIBIN B; KISSPEPTIN; LUTEINIZING HORMONE; NEUROKININ 3 RECEPTOR; NEUROKININ B; TESTOSTERONE; KISSPEPTIN 10; STEROID;

ADULT; ARTICLE; CASE REPORT; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TESTOSTERONE BLOOD LEVEL; ABSENCE OF SIDE EFFECTS; GONADOTROPIN RELEASE; HORMONE BLOOD LEVEL; HYPOGONADOTROPIC HYPOGONADISM; NEUROKININ B SIGNALING DEFICIENCY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN DEFICIENCY; PULSATILE HORMONE RELEASE; PULSE RATE; YOUNG ADULT;

ADULT; DISORDERS OF SEX DEVELOPMENT; ESTRADIOL; FEMALE; HUMANS; INHIBINS; KISSPEPTINS; LUTEINIZING HORMONE; MALE; MUTATION; NEUROKININ B; PULSATILE FLOW; RECEPTORS, NEUROKININ-3; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 84876289515     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000336376     Document Type: Article

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