Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat

Neuroendocrinology

Volumn 80, Issue 4, 2004, Pages 264-272

  Irwig, Michael S ^a   Fraley, Gregory S ^a   Smith, Jeremy T ^a   Acohido, Blake V ^b   Popa, Simina M ^a   Cunningham, Matthew J ^a   Gottsch, Michelle L ^a   Clifton, Donald K ^b   Steiner, Robert A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Arcuate nucleus; Follicle stimulating hormone; Fos; G protein coupled receptors; Gonadal steroids; Gonadotropin releasing hormone; Kisspeptin; Luteinizing hormone

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GONADORELIN; GONADORELIN ANTAGONIST; KISSPEPTIN 52; LUTEINIZING HORMONE; MESSENGER RNA; NEUROPEPTIDE; PROTEIN FOS; SEX HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CASTRATION; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE CONTROL; GENE EXPRESSION; HORMONE RELEASE; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; LATERAL BRAIN VENTRICLE; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RNA ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSCRIPTION INITIATION;

ANIMALS; CASTRATION; CELL COUNT; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INJECTIONS, INTRAVENTRICULAR; LUTEINIZING HORMONE; MALE; NEURONS; OLIGOPEPTIDES; ONCOGENE PROTEINS V-FOS; PEPTIDES; PROTEINS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; STATISTICS, NONPARAMETRIC;

EID: 13244255747     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083140     Document Type: Article

References (31)

1. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A 2003;100:10972-10976.
2. Funes S, Hedrick JA, Vassileva G, Markowitz L, Abbondanzo S, Golovko A, Yang S, Monsma FJ, Gustafson EL: The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system. Biochem Biophys Res Commun 2003;312:1357-1363.
3. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH: The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614-1627.
4. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 2001;276:34631-34636.
5. Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF: Discovery of a receptor related to the galanin receptors. FEBS Lett 1999;446:103-107.
6. Stafford LJ, Xia C, Ma W, Cai Y, Liu M: Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res 2002;62:5399-5404.
7. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 2001;411:613-617.
8. Sahu A, Crowley WR, Tatemoto K, Balasubramaniam A, Kalra SP: Effects of neuropeptide Y, NPY analog (norleucine4-NPY), galanin and neuropeptide K on LH release in ovariectomized (ovx) and ovx estrogen, progesteronetreated rats. Peptides 1987;8:921-926.
9. Horvath TL, Pu S, Dube MG, Diano S, Kalra SP: A GABA-neuropeptide Y (NPY) interplay in LH release. Peptides 2001;22:473-481.
10. Jiang G, Stalewski J, Galyean R, Dykert J, Schteingart C, Broqua P, Aebi A, Aubert ML, Semple G, Robson P, Akinsanya K, Haigh R, Riviere P, Trojnar J, Junien JL, Rivier JE: GnRH antagonists: A new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6. J Med Chem 2001;44:453-467.
11. Vilchez-Martinez JA, Pedroza E, Coy DH, Arimura A, Schally AV: Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D-Leu6, desGly-NH2(10)]-LH-RH ethylamide. Proc Soc Exp Biol Med 1977;154:427-430.
12. Fraley GS, Shimada I, Baumgartner JW, Clifton DK, Steiner RA: Differential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galanin. Endocrinology 2003;144:1143-1146.
13. Urbanski HF: Monoclonal antibodies to luteinizing hormone-releasing hormone: Production, characterization, and immunocytochemical application. Biol Reprod 1991;44:681-686.
14. Silverman AJ, Livne I, Witkin JW: The gonadotropin-releasing hormone (GnRH) neuronal systems: Immunocytochemistry and in situ hybridization; in Knobil E, Neill JD (eds):The Physiology of Reproduction. New York, Raven Press, 1994, pp 1683-1709.
15. Cunningham MJ, Scarlett JM, Steiner RA: Cloning and distribution of galanin-like peptide mRNA in the hypothalamus and pituitary of the macaque. Endocrinology 2002;143:755-763.
16. Chowen JA, Clifton DK: Semiquantitative analysis of cellular somatostatin mRNA levels by in situ hybridization histochemistry. Methods Neurosci 1991;5:137-158.
17. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA: A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 2004;145:4073-4077.
18. Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki T: Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 2004;320:383-388.
19. Small CJ, Goubillon ML, Murray JF, Siddiqui A, Grimshaw SE, Young H, Sivanesan V, Kalamatianos T, Kennedy AR, Coen CW, Bloom SR, Wilson CA: Central orexin A has site-specific effects on luteinizing hormone release in female rats. Endocrinology 2003;144:3225-3236.
20. Poulain P, Decrocq N, Mitchell V: Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-R1 mRNA. Neuroendocrinology 2003;78:105-117.
21. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC: AXOR12, a novel human G proteincoupled receptor, activated by the peptide KiSS-1. J Biol Chem 2001;276:28969-28975.
22. Lee WS, Smith MS, Hoffman GE: Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone. Proc Natl Acad Sci USA 1990;87:5163-5167.
23. Wang HJ, Hoffman GE, Smith MS: Increased GnRH mRNA in the GnRH neurons expressing cFos during the proestrous LH surge. Endocrinology 1995;136:3673-3676.
24. Matsumoto H, Noguchi J, Takatsu Y, Horikoshi Y, Kumano S, Ohtaki T, Kitada C, Itoh T, Onda H, Nishimura O, Fujino M: Stimulation effect of galanin-like peptide (GALP) on luteinizing hormone-releasing hormone-mediated luteinizing hormone (LH) secretion in male rats. Endocrinology 2001;142:3693-3696.
25. Mitsushima D, Funabashi T, Kimura F: Fos expression in gonadotropin-releasing hormone neurons by naloxone or bicuculline in intact male rats. Brain Res 1999;839:209-212.
26. Parhar IS, Ogawa S, Sakuma Y: Laser-captured single digoxigenin-labeled neurons of gonadotropin-releasing hormone types reveal a novel G protein-coupled receptor (Gpr54) during maturation in cichlid fish. Endocrinology 2004;145:3613-3618.
27. Macrez-Leprètre N, Kalkbrenner F, Schultz G, Mironneau J: Distinct functions of Gq and G11 proteins in coupling alpha1-adrenoreceptors to Ca2+ release and Ca2+ entry in rat portal vein myocytes. J Biol Chem 1997;272:5261-5268.
28. Wang C, Jayadev S, Escobedo JA: Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras. J Biol Chem 1995;270:16677-16682.
29. Mitchell V, Bouret S, Prevot V, Jennes L, Beauvillain JC: Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area. J Neuroendocrinol 1999;11:805-812.
30. Campbell RE, Grove KL, Smith MS: Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers. Endocrinology 2003;144:1542-1548.
31. Navarro VM, Castellano JM, Fernandez-Fernandez R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M: Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormonereleasing activity of KiSS-1 peptide. Endocrinology 2004;145:4565-4574.