The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat

Endocrinology

Volumn 153, Issue 1, 2012, Pages 307-315

  Kinsey Jones, James S ^a   Grachev, Pasha ^a   Li, Xiao Feng ^a   Lin, Yuan Shao ^a   Milligan, Stuart R ^a   Lightman, Stafford L ^b   O'Byrne, Kevin T ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN A; ESTRADIOL; G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; KAPPA OPIATE RECEPTOR; KISSPEPTIN; LUTEINIZING HORMONE; NEUROKININ B; NORBINALTORPHIMINE; SENKTIDE;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ELECTRODE; ELECTROPHYSIOLOGY; FEMALE; HORMONE RELEASE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; PULSE GENERATOR; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ARCUATE NUCLEUS; DYNORPHINS; FEMALE; GONADOTROPIN-RELEASING HORMONE; KISSPEPTINS; LUTEINIZING HORMONE; NEUROKININ B; OVARIECTOMY; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROKININ-3; RECEPTORS, OPIOID; RECEPTORS, OPIOID, KAPPA; SIGNAL TRANSDUCTION; SUBSTANCE P;

EID: 84455160693     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1641     Document Type: Article

References (26)

1. Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O'Rahilly S, Semple RK 2009 TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction. Nat Genet 41:354-358
2. Burke MC, Letts PA, Krajewski SJ, Rance NE 2006 Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol 498:712-726 (Pubitemid 44350359)
3. Knobil E 1990 The GnRH pulse generator. Am J Obstet Gynecol 163:1721-1727
4. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H 2010 Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 30:3124-3132
5. Sandoval-Guzmán T, Rance NE 2004 Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. Brain Res 1026:307-312 (Pubitemid 39361561)
6. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA 2009 Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/ neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 29:11859-11866
7. Ramaswamy S, Seminara SB, Ali B, Ciofi P, Amin NA, Plant TM 2010 Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology 151:40494-44503
8. Billings HJ, Connors JM, Altman SN, Hileman SM, Holaskova I, Lehman MN, McManus CJ, Nestor CC, Jacobs BH, Goodman RL 2010 Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology 151:3836-3846
9. Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA 2011 Interactions between kisspeptin and neurokinin B in the control ofGnRH secretion in the female rat. Am J Physiol Endocrinol Metab 300: E202-E210
10. O'Byrne KT, Knobil E 1993 Electrophysiological approaches to gonadotrophin releasing hormone pulse generator activity in the rhesus monkey. Hum Reprod 8:37-40 (Pubitemid 23337175)
11. Kinsey-Jones JS, Li XF, Luckman SM, O'Byrne KT 2008 Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin- releasing hormone pulse generator activity in the female rat. Endocrinology 149:1004-1008 (Pubitemid 351397949)
12. McGarvey C, Cates PA, Brooks A, Swanson IA, Milligan SR, Coen CW, O'Byrne KT 2001 Phytoestrogens and gonadotropin-releasing hormone pulse generator activity and pituitary luteinizing hormone release in the rat. Endocrinology 142:1202-1208 (Pubitemid 32202830)
13. Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda KI, Okamura H 2009 Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol 21:813-821
14. Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Topaloglu AK, Yeo GS, O'Rahilly S, Dhillo WS, Semple RK, Coll AP 2010 The effects of neurokinin B upon gonadotrophin release in male rodents. J Neuroendocrinol 22:181-187
15. Cagampang FR, Maeda KI, Tsukamura H, Ohkura S, Ota K 1991 Involvement of ovarian steroids and endogenous opioids in the fasting- induced suppression of pulsatile LH release in ovariectomized rats. J Endocrinol 129:321-328
16. Li XF, Mitchell JC, Wood S, Coen CW, Lightman SL, O'Byrne KT 2003 The effect of oestradiol and progesterone on hypoglycaemic stress-induced suppression of pulsatile luteinizing hormone release and on corticotropin- releasing hormone mRNA expression in the rat. J Neuroendocrinol 15:468-476 (Pubitemid 36582462)
17. Li XF, Kinsey-Jones JS, Cheng Y, Knox AM, Lin Y, Petrou NA, Roseweir A, Lightman SL, Milligan SR, Millar RP, O'Byrne KT 2009 Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One 4:e8334
18. Paxinos G, Watson C 1986 The rat brain in stereotaxic coordinates. 2nd ed. London: Academic Press
19. Monroe SE, Parlow AF, Midgley Jr AR 1968 Radioimmunoassay for rat luteinizing hormone. Endocrinology 83:1004-1012
20. Van Cauter E 1988 Estimating false-positive and false-negative errors in analyses of hormonal pulsatility. Am J Physiol 254:E786-E794
21. Rance NE 2009 Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback. Peptides 30:111-122
22. Rance NE, Bruce TR 1994 Neurokinin B gene expression is increased in the arcuate nucleus of ovariectomized rats. Neuroendocrinology 60:337-345 (Pubitemid 24284817)
23. Rance NE, Krajewski SJ, Smith MA, Cholanian M, Dacks PA 2010 Neurokinin B and the hypothalamic regulation of reproduction. Brain Res 1364:116-128
24. Kinoshita F, Nakai Y, Katakami H, Imura H 1982 Suppressive effect of dynorphin-(1-13) on luteinizing hormone release in conscious castrated rats. Life Sci 30:1915-1919 (Pubitemid 12098885)
25. Bowe JE, Li XF, Kinsey-Jones JS, Paterson S, Brain SD, Lightman SL, O'Byrne KT 2005 Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat: the role of endogenous opioid peptides. J Physiol 566:921-928 (Pubitemid 41122671)
26. Jayasena CN, Dhillo WS 2010 Neurokinin B and kisspeptin: sexual partners or single agents? Endocrinology 151:4090-4091