Lysosomal enzyme Glucocerebrosidase protects against Aβ1-42 oligomer-induced neurotoxicity

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Choi, Seulah ^a,c   Kim, Donghoon ^a,c   Kam, Tae In ^a   Yun, Seungpil ^a,b   Kim, Sangjune ^a   Park, Hyejin ^a   Hwang, Heehong ^a   Pletnikova, Olga ^a   Troncoso, Juan C ^a   Dawson, Valina L ^a,b   Dawson, Ted M ^a,b   Ko, Han Seok ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATION   (United States)

^c Diana Helis Henry Medical Research Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GLUCOSYLCERAMIDASE; LYSOSOME ENZYME; OLIGOMER; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

ACIDIFICATION; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; HUMAN TISSUE; LYSOSOME; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOLOGY; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CELL DEATH; GLUCOSYLCERAMIDASE; HIPPOCAMPUS; HUMANS; LYSOSOMES; NEURONS; NEUROPROTECTION; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS;

EID: 84955492230     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143854     Document Type: Article

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