-
1
-
-
28044433451
-
Protein posttranslational modifications: The chemistry of proteome diversifications
-
Walsh, C. T., Garneau-Tsodikova, S. & Gatto, G. J. Protein posttranslational modifications: the chemistry of proteome diversifications. Angew. Chem. Int. Ed. 44, 7342-7372 (2005).
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 7342-7372
-
-
Walsh, C.T.1
Garneau-Tsodikova, S.2
Gatto, G.J.3
-
2
-
-
81355139629
-
Choosing an effective protein bioconjugation strategy
-
Stephanopoulos, N. & Francis, M. B. Choosing an effective protein bioconjugation strategy. Nature Chem. Biol. 7, 876-884 (2011).
-
(2011)
Nature Chem. Biol.
, vol.7
, pp. 876-884
-
-
Stephanopoulos, N.1
Francis, M.B.2
-
3
-
-
67649130281
-
Chemical modification of proteins at cysteine: Opportunities in chemistry and biology
-
Chalker, J. M., Bernardes, G. J. L., Lin, Y. A. & Davis, B. G. Chemical modification of proteins at cysteine: opportunities in chemistry and biology. Chem. Asian J. 4, 630-640 (2009).
-
(2009)
Chem. Asian J.
, vol.4
, pp. 630-640
-
-
Chalker, J.M.1
Bernardes, G.J.L.2
Lin, Y.A.3
Davis, B.G.4
-
4
-
-
0030059104
-
Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins
-
Gaertner, H. F. & Offord, R. E. Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins. Bioconjugate Chem. 7, 38-44 (1996).
-
(1996)
Bioconjugate Chem.
, vol.7
, pp. 38-44
-
-
Gaertner, H.F.1
Offord, R.E.2
-
5
-
-
0027944205
-
Synthesis of proteins by native chemical ligation
-
Dawson, P., Muir, T., Clark-Lewis, I. & Kent, S. Synthesis of proteins by native chemical ligation. Science 266, 776-779 (1994).
-
(1994)
Science
, vol.266
, pp. 776-779
-
-
Dawson, P.1
Muir, T.2
Clark-Lewis, I.3
Kent, S.4
-
6
-
-
33749019097
-
A chemical toolkit for proteins - An expanded genetic code
-
Xie, J. & Schultz, P. G. A chemical toolkit for proteins - an expanded genetic code. Nature Rev. Mol. Cell Biol. 7, 775-782 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol.
, vol.7
, pp. 775-782
-
-
Xie, J.1
Schultz, P.G.2
-
7
-
-
84857451064
-
Designer proteins: Applications of genetic code expansion in cell biology
-
Davis, L. & Chin, J. W. Designer proteins: applications of genetic code expansion in cell biology. Nature Rev. Mol. Cell Biol. 13, 168-182 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 168-182
-
-
Davis, L.1
Chin, J.W.2
-
8
-
-
84899077284
-
Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins
-
Lang, K. & Chin, J. W. Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chem. Rev. 114, 4764-4806 (2014).
-
(2014)
Chem. Rev.
, vol.114
, pp. 4764-4806
-
-
Lang, K.1
Chin, J.W.2
-
9
-
-
70349917806
-
Bioorthogonal chemistry: Fishing for selectivity in a sea of functionality
-
Sletten, E. M. & Bertozzi, C. R. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew. Chem. Int. Ed. 48, 6974-6998 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 6974-6998
-
-
Sletten, E.M.1
Bertozzi, C.R.2
-
10
-
-
84900339887
-
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
-
Elliott, T. S. et al. Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal. Nature Biotech. 32, 465-472 (2014).
-
(2014)
Nature Biotech.
, vol.32
, pp. 465-472
-
-
Elliott, T.S.1
-
11
-
-
84907515407
-
More than add-on: Chemoselective reactions for the synthesis of functional peptides and proteins
-
Schumacher, D. & Hackenberger, C. P. R. More than add-on: chemoselective reactions for the synthesis of functional peptides and proteins. Curr. Opin. Chem. Biol. 22, 62-69 (2014).
-
(2014)
Curr. Opin. Chem. Biol.
, vol.22
, pp. 62-69
-
-
Schumacher, D.1
Hackenberger, C.P.R.2
-
12
-
-
84918498938
-
Selective chemical protein modification
-
Spicer, C. D. & Davis, B. G. Selective chemical protein modification. Nature Commun. 5, 4740 (2014).
-
(2014)
Nature Commun.
, vol.5
, pp. 4740
-
-
Spicer, C.D.1
Davis, B.G.2
-
13
-
-
84893232945
-
Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo
-
Arur, S. & Schedl, T. Generation and purification of highly specific antibodies for detecting post-translationally modified proteins in vivo. Nature Protoc. 9, 375-395 (2014).
-
(2014)
Nature Protoc.
, vol.9
, pp. 375-395
-
-
Arur, S.1
Schedl, T.2
-
14
-
-
33751211249
-
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
-
Burckstummer, T. et al. An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells. Nature Methods 3, 1013-1019 (2006).
-
(2006)
Nature Methods
, vol.3
, pp. 1013-1019
-
-
Burckstummer, T.1
-
15
-
-
84890107812
-
Erythropoietin derived by chemical synthesis
-
Wang, P. et al. Erythropoietin derived by chemical synthesis. Science 342, 1357-1360 (2013).
-
(2013)
Science
, vol.342
, pp. 1357-1360
-
-
Wang, P.1
-
16
-
-
0032499752
-
Expressed protein ligation: A general method for protein engineering
-
Muir, T. W., Sondhi, D. & Cole, P. A. Expressed protein ligation: a general method for protein engineering. Proc. Natl Acad. Sci. USA 95, 6705-6710 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 6705-6710
-
-
Muir, T.W.1
Sondhi, D.2
Cole, P.A.3
-
17
-
-
84859836380
-
Chromatin as an expansive canvas for chemical biology
-
Fierz, B. & Muir, T. W. Chromatin as an expansive canvas for chemical biology. Nature Chem. Biol. 8, 417-427 (2012).
-
(2012)
Nature Chem. Biol.
, vol.8
, pp. 417-427
-
-
Fierz, B.1
Muir, T.W.2
-
18
-
-
84883815400
-
H3R42me2a is a histone modification with positive transcriptional effects
-
Casadio, F. et al. H3R42me2a is a histone modification with positive transcriptional effects. Proc. Natl Acad. Sci. USA 110, 14894-14899 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 14894-14899
-
-
Casadio, F.1
-
19
-
-
84879416831
-
A pan-specific antibody for direct detection of protein histidine phosphorylation
-
Kee, J.-M., Oslund, R. C., Perlman, D. H. & Muir, T. W. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nature Chem. Biol. 9, 416-421 (2013).
-
(2013)
Nature Chem. Biol.
, vol.9
, pp. 416-421
-
-
Kee, J.-M.1
Oslund, R.C.2
Perlman, D.H.3
Muir, T.W.4
-
20
-
-
81355138529
-
Methods for converting cysteine to dehydroalanine on peptides and proteins
-
Chalker, J. M. et al. Methods for converting cysteine to dehydroalanine on peptides and proteins. Chem. Sci. 2, 1666-1676 (2011).
-
(2011)
Chem. Sci.
, vol.2
, pp. 1666-1676
-
-
Chalker, J.M.1
-
21
-
-
84893770102
-
Synthetic phosphorylation of p38α recapitulates protein kinase activity
-
Chooi, K. P. et al. Synthetic phosphorylation of p38α recapitulates protein kinase activity. J. Am. Chem. Soc. 136, 1698-1701 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 1698-1701
-
-
Chooi, K.P.1
-
22
-
-
70350015400
-
Chemoselective staudinger-phosphite reaction of azides for the phosphorylation of proteins
-
Serwa, R. et al. Chemoselective Staudinger-phosphite reaction of azides for the phosphorylation of proteins. Angew. Chem. Int. Ed. 48, 8234-8239 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 8234-8239
-
-
Serwa, R.1
-
23
-
-
84856887479
-
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications
-
Chalker, J. M., Lercher, L., Rose, N. R., Schofield, C. J. & Davis, B. G. Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angew. Chem. Int. Ed. 51, 1835-1839 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 1835-1839
-
-
Chalker, J.M.1
Lercher, L.2
Rose, N.R.3
Schofield, C.J.4
Davis, B.G.5
-
24
-
-
33847386172
-
The site-specific installation of methyl-lysine analogs into recombinant histones
-
Simon, M. D. et al. The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 128, 1003-1012 (2007).
-
(2007)
Cell
, vol.128
, pp. 1003-1012
-
-
Simon, M.D.1
-
25
-
-
77955810448
-
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation
-
Huang, R. et al. Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. J. Am. Chem. Soc. 132, 9986-9987 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 9986-9987
-
-
Huang, R.1
-
26
-
-
77949874828
-
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation
-
Chatterjee, C., McGinty, R. K., Fierz, B. & Muir, T. W. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nature Chem. Biol. 6, 267-269 (2010).
-
(2010)
Nature Chem. Biol.
, vol.6
, pp. 267-269
-
-
Chatterjee, C.1
McGinty, R.K.2
Fierz, B.3
Muir, T.W.4
-
27
-
-
80053557477
-
A direct method for site-specific protein acetylation
-
Li, F. et al. A direct method for site-specific protein acetylation. Angew. Chem. Int. Ed. 50, 9611-9614 (2011).
-
(2011)
Angew. Chem. Int. Ed.
, vol.50
, pp. 9611-9614
-
-
Li, F.1
-
28
-
-
79960209051
-
Traceless and site-specific ubiquitination of recombinant proteins
-
Virdee, S. et al. Traceless and site-specific ubiquitination of recombinant proteins. J. Am. Chem. Soc. 133, 10708-10711 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 10708-10711
-
-
Virdee, S.1
-
29
-
-
77956903406
-
Engineered diubiquitin synthesis reveals lys29-isopeptide specificity of an OTU deubiquitinase
-
Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nature Chem. Biol. 6, 750-757 (2010).
-
(2010)
Nature Chem. Biol.
, vol.6
, pp. 750-757
-
-
Virdee, S.1
Ye, Y.2
Nguyen, D.P.3
Komander, D.4
Chin, J.W.5
-
30
-
-
84928604958
-
Ubiquitination of the dishevelled DIX domain blocks its head-to-tail polymerization
-
Madrzak, J. et al. Ubiquitination of the dishevelled DIX domain blocks its head-to-tail polymerization. Nature Commun. 6, 6718 (2015).
-
(2015)
Nature Commun.
, vol.6
, pp. 6718
-
-
Madrzak, J.1
-
31
-
-
84911452299
-
Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains
-
Schneider, T. et al. Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew. Chem. Int. Ed. 53, 12925-12929 (2014).
-
(2014)
Angew. Chem. Int. Ed.
, vol.53
, pp. 12925-12929
-
-
Schneider, T.1
-
32
-
-
84894206539
-
Nonenzymatic polyubiquitination of expressed proteins
-
Hemantha, H. P. et al. Nonenzymatic polyubiquitination of expressed proteins. J. Am. Chem. Soc. 136, 2665-2673 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 2665-2673
-
-
Hemantha, H.P.1
-
33
-
-
34247622775
-
Expanding the diversity of chemical protein modification allows post-translational mimicry
-
van Kasteren, S. I. et al. Expanding the diversity of chemical protein modification allows post-translational mimicry. Nature 446, 1105-1109 (2007).
-
(2007)
Nature
, vol.446
, pp. 1105-1109
-
-
Van Kasteren, S.I.1
-
34
-
-
70349765673
-
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation
-
Neumann, H. et al. A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol. Cell 36, 153-163 (2009).
-
(2009)
Mol. Cell
, vol.36
, pp. 153-163
-
-
Neumann, H.1
-
35
-
-
84865145661
-
Influence of DOTA chelator position on biodistribution and targeting properties of 111In-labeled synthetic anti-HER2 affibody molecules
-
Perols, A. et al. Influence of DOTA chelator position on biodistribution and targeting properties of 111In-labeled synthetic anti-HER2 affibody molecules. Bioconjugate Chem. 23, 1661-1670 (2012).
-
(2012)
Bioconjugate Chem.
, vol.23
, pp. 1661-1670
-
-
Perols, A.1
-
36
-
-
49449087300
-
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
-
Junutula, J. R. et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nature Biotech. 26, 925-932 (2008).
-
(2008)
Nature Biotech.
, vol.26
, pp. 925-932
-
-
Junutula, J.R.1
-
37
-
-
84901952283
-
Concerted, rapid, quantitative, and site-specific dual labeling of proteins
-
Sachdeva, A., Wang, K., Elliott, T. & Chin, J. W. Concerted, rapid, quantitative, and site-specific dual labeling of proteins. J. Am. Chem. Soc. 136, 7785-7788 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 7785-7788
-
-
Sachdeva, A.1
Wang, K.2
Elliott, T.3
Chin, J.W.4
-
38
-
-
84872410649
-
-
(ed. Michael Conn, P.) Ch. 9, (Academic Press)
-
Tyagi, S. & Lemke, E. A. in Methods in Cell Biology, Vol. 113 (ed. Michael Conn, P.) Ch. 9, 169-187 (Academic Press, 2013).
-
(2013)
Methods in Cell Biology
, vol.113
, pp. 169-187
-
-
Tyagi, S.1
Lemke, E.A.2
-
39
-
-
84899055551
-
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET
-
Wang, K. et al. Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET. Nature Chem. 6, 393-403 (2014).
-
(2014)
Nature Chem.
, vol.6
, pp. 393-403
-
-
Wang, K.1
-
40
-
-
84857445877
-
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
-
Lang, K. et al. Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. Nature Chem. 4, 298-304 (2012).
-
(2012)
Nature Chem.
, vol.4
, pp. 298-304
-
-
Lang, K.1
-
41
-
-
84902239684
-
Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling
-
Zheng, S., Zhang, G., Li, J. & Chen, P. R. Monitoring endocytic trafficking of anthrax lethal factor by precise and quantitative protein labeling. Angew. Chem. Int. Ed. 53, 6449-6453 (2014).
-
(2014)
Angew. Chem. Int. Ed.
, vol.53
, pp. 6449-6453
-
-
Zheng, S.1
Zhang, G.2
Li, J.3
Chen, P.R.4
-
42
-
-
84881407469
-
A pretargeted pet imaging strategy based on bioorthogonal diels-alder click chemistry
-
Zeglis, B. M. et al. A pretargeted pet imaging strategy based on bioorthogonal Diels-Alder click chemistry. J. Nucl. Med. 54, 1389-1396 (2013).
-
(2013)
J. Nucl. Med.
, vol.54
, pp. 1389-1396
-
-
Zeglis, B.M.1
-
43
-
-
84955467413
-
Use of 18F-2-fluorodeoxyglucose to label antibody fragments for immuno-positron emission tomography of pancreatic cancer
-
Rashidian, M. et al. Use of 18F-2-fluorodeoxyglucose to label antibody fragments for immuno-positron emission tomography of pancreatic cancer. ACS Cent. Sci. 1, 142-147 (2015).
-
(2015)
ACS Cent. Sci.
, vol.1
, pp. 142-147
-
-
Rashidian, M.1
-
44
-
-
84891690168
-
Diels-alder reaction for tumor pretargeting: In vivo chemistry can boost tumor radiation dose compared with directly labeled antibody
-
Rossin, R., Läppchen, T., van den Bosch, S. M., Laforest, R. & Robillard, M. S. Diels-Alder reaction for tumor pretargeting: in vivo chemistry can boost tumor radiation dose compared with directly labeled antibody. J. Nucl. Med. 54, 1989-1995 (2013).
-
(2013)
J. Nucl. Med.
, vol.54
, pp. 1989-1995
-
-
Rossin, R.1
Läppchen, T.2
Van Den-Bosch, S.M.3
Laforest, R.4
Robillard, M.S.5
-
45
-
-
84856873462
-
Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes
-
Seitchik, J. L. et al. Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes. J. Am. Chem. Soc. 134, 2898-2901 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 2898-2901
-
-
Seitchik, J.L.1
-
46
-
-
84864414709
-
Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity
-
Yang, M. et al. Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity. Angew. Chem. Int. Ed. 51, 7674-7679 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 7674-7679
-
-
Yang, M.1
-
47
-
-
84898066972
-
Antibody-drug conjugates: An emerging concept in cancer therapy
-
Chari, R. V. J., Miller, M. L. & Widdison, W. C. Antibody-drug conjugates: an emerging concept in cancer therapy. Angew. Chem. Int. Ed. 53, 3796-3827 (2014).
-
(2014)
Angew. Chem. Int. Ed.
, vol.53
, pp. 3796-3827
-
-
Chari, R.V.J.1
Miller, M.L.2
Widdison, W.C.3
-
48
-
-
70349988803
-
PEG conjugates in clinical development or use as anticancer agents: An overview
-
Pasut, G. & Veronese, F. M. PEG conjugates in clinical development or use as anticancer agents: an overview. Adv. Drug Deliv. Rev. 61, 1177-1188 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 1177-1188
-
-
Pasut, G.1
Veronese, F.M.2
-
49
-
-
80051753313
-
FDA-approved poly(ethylene glycol)-protein conjugate drugs
-
Alconcel, S. N. S., Baas, A. S. & Maynard, H. D. FDA-approved poly(ethylene glycol)-protein conjugate drugs. Polym. Chem. 2, 1442-1448 (2011).
-
(2011)
Polym. Chem.
, vol.2
, pp. 1442-1448
-
-
Alconcel, S.N.S.1
Baas, A.S.2
Maynard, H.D.3
-
50
-
-
83655197598
-
Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity
-
Keefe, A. J. & Jiang, S. Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. Nature Chem. 4, 59-63 (2012).
-
(2012)
Nature Chem.
, vol.4
, pp. 59-63
-
-
Keefe, A.J.1
Jiang, S.2
-
51
-
-
84908004705
-
Therapeutic protein-polymer conjugates: Advancing beyond pegylation
-
Pelegri-O'Day, E. M., Lin, E.-W. & Maynard, H. D. Therapeutic protein-polymer conjugates: advancing beyond pegylation. J. Am. Chem. Soc. 136, 14323-14332 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 14323-14332
-
-
Pelegri-O'Day, E.M.1
Lin, E.-W.2
Maynard, H.D.3
-
52
-
-
33747880302
-
N-terminal protein modification through a biomimetic transamination reaction
-
Gilmore, J. M., Scheck, R. A., Esser-Kahn, A. P., Joshi, N. S. & Francis, M. B. N-terminal protein modification through a biomimetic transamination reaction. Angew. Chem. Int. Ed. 45, 5307-5311 (2006).
-
(2006)
Angew. Chem. Int. Ed.
, vol.45
, pp. 5307-5311
-
-
Gilmore, J.M.1
Scheck, R.A.2
Esser-Kahn, A.P.3
Joshi, N.S.4
Francis, M.B.5
-
53
-
-
84932182042
-
One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes
-
MacDonald, J. I., Munch, H. K., Moore, T. & Francis, M. B. One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes. Nature Chem. Biol. 11, 326-331 (2015).
-
(2015)
Nature Chem. Biol.
, vol.11
, pp. 326-331
-
-
MacDonald, J.I.1
Munch, H.K.2
Moore, T.3
Francis, M.B.4
-
54
-
-
79959370195
-
Optimized clinical performance of growth hormone with an expanded genetic code
-
Cho, H. et al. Optimized clinical performance of growth hormone with an expanded genetic code. Proc. Natl Acad. Sci. USA 108, 9060-9065 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9060-9065
-
-
Cho, H.1
-
55
-
-
0026593928
-
Immunoconjugates containing novel maytansinoids: Promising anticancer drugs
-
Chari, R. V. J. et al. Immunoconjugates containing novel maytansinoids: promising anticancer drugs. Cancer Res. 52, 127-131 (1992).
-
(1992)
Cancer Res.
, vol.52
, pp. 127-131
-
-
Chari, R.V.J.1
-
56
-
-
84885993126
-
Investigation into temperature-induced aggregation of an antibody drug conjugate
-
Beckley, N. S., Lazzareschi, K. P., Chih, H.-W., Sharma, V. K. & Flores, H. L. Investigation into temperature-induced aggregation of an antibody drug conjugate. Bioconjugate Chem. 24, 1674-1683 (2013).
-
(2013)
Bioconjugate Chem.
, vol.24
, pp. 1674-1683
-
-
Beckley, N.S.1
Lazzareschi, K.P.2
Chih, H.-W.3
Sharma, V.K.4
Flores, H.L.5
-
57
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
Hamblett, K. J. et al. Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin. Cancer Res. 10, 7063-7070 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 7063-7070
-
-
Hamblett, K.J.1
-
58
-
-
84863012529
-
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
-
Shen, B.-Q. et al. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates. Nature Biotech. 30, 184-189 (2012).
-
(2012)
Nature Biotech.
, vol.30
, pp. 184-189
-
-
Shen, B.-Q.1
-
59
-
-
84874433614
-
Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature
-
Steiner, M. et al. Spacer length shapes drug release and therapeutic efficacy of traceless disulfide-linked ADCs targeting the tumor neovasculature. Chem. Sci. 4, 297-302 (2013).
-
(2013)
Chem. Sci.
, vol.4
, pp. 297-302
-
-
Steiner, M.1
-
60
-
-
84922713475
-
Cysteine-selective reactions for antibody conjugation
-
Cal, P. M. S. D., Bernardes, G. J. L. & Gois, P. M. P. Cysteine-selective reactions for antibody conjugation. Angew. Chem. Int. Ed. 53, 10585-10587 (2014).
-
(2014)
Angew. Chem. Int. Ed.
, vol.53
, pp. 10585-10587
-
-
Cal, P.M.S.D.1
Bernardes, G.J.L.2
Gois, P.M.P.3
-
61
-
-
84921407368
-
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates
-
Lyon, R. P. et al. Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates. Nature Biotech. 32, 1059-1062 (2014).
-
(2014)
Nature Biotech.
, vol.32
, pp. 1059-1062
-
-
Lyon, R.P.1
-
62
-
-
84908052265
-
Mild method for succinimide hydrolysis on ADCs: Impact on adc potency, stability, exposure, and efficacy
-
Tumey, L. N. et al. Mild method for succinimide hydrolysis on ADCs: impact on adc potency, stability, exposure, and efficacy. Bioconjugate Chem. 25, 1871-1880 (2014).
-
(2014)
Bioconjugate Chem.
, vol.25
, pp. 1871-1880
-
-
Tumey, L.N.1
-
63
-
-
84887976957
-
Rapid, stable, chemoselective labeling of thiols with julia-kocieński-like reagents: A serum-stable alternative to maleimide-based protein conjugation
-
Toda, N., Asano, S. & Barbas, C. F. Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation. Angew. Chem. Int. Ed. 52, 12592-12596 (2013).
-
(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 12592-12596
-
-
Toda, N.1
Asano, S.2
Barbas, C.F.3
-
64
-
-
42149123238
-
Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: Versatile and switchable access to functionalized proteins
-
Bernardes, G. J. L., Chalker, J. M., Errey, J. C. & Davis, B. G. Facile conversion of cysteine and alkyl cysteines to dehydroalanine on protein surfaces: versatile and switchable access to functionalized proteins. J. Am. Chem. Soc. 130, 5052-5053 (2008).
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 5052-5053
-
-
Bernardes, G.J.L.1
Chalker, J.M.2
Errey, J.C.3
Davis, B.G.4
-
65
-
-
84867040452
-
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids
-
Axup, J. Y. et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc. Natl Acad. Sci. USA 109, 16101-16106 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16101-16106
-
-
Axup, J.Y.1
-
66
-
-
84893452692
-
A general approach to site-specific antibody drug conjugates
-
Tian, F. et al. A general approach to site-specific antibody drug conjugates. Proc. Natl Acad. Sci. USA 111, 1766-1771 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 1766-1771
-
-
Tian, F.1
-
67
-
-
84871947711
-
A pictet-spengler ligation for protein chemical modification
-
Agarwal, P., van der Weijden, J., Sletten, E. M., Rabuka, D. & Bertozzi, C. R. A Pictet-Spengler ligation for protein chemical modification. Proc. Natl Acad. Sci. USA 110, 46-51 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 46-51
-
-
Agarwal, P.1
Van Der-Weijden, J.2
Sletten, E.M.3
Rabuka, D.4
Bertozzi, C.R.5
-
68
-
-
84904408813
-
Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes
-
Drake, P. M. et al. Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes. Bioconjugate Chem. 25, 1331-1341 (2014).
-
(2014)
Bioconjugate Chem.
, vol.25
, pp. 1331-1341
-
-
Drake, P.M.1
-
69
-
-
84896965494
-
Palladium-triggered deprotection chemistry for protein activation in living cells
-
Li, J. et al. Palladium-triggered deprotection chemistry for protein activation in living cells. Nature Chem. 6, 352-361 (2014).
-
(2014)
Nature Chem.
, vol.6
, pp. 352-361
-
-
Li, J.1
-
70
-
-
84920476853
-
Diels-alder reaction-triggered bioorthogonal protein decaging in living cells
-
Li, J., Jia, S. & Chen, P. R. Diels-Alder reaction-triggered bioorthogonal protein decaging in living cells. Nature Chem. Biol. 10, 1003-1005 (2014).
-
(2014)
Nature Chem. Biol.
, vol.10
, pp. 1003-1005
-
-
Li, J.1
Jia, S.2
Chen, P.R.3
-
71
-
-
84890704870
-
Click to release: Instantaneous doxorubicin elimination upon tetrazine ligation
-
Versteegen, R. M., Rossin, R., ten Hoeve, W., Janssen, H. M. & Robillard, M. S. Click to release: instantaneous doxorubicin elimination upon tetrazine ligation. Angew. Chem. Int. Ed. 52, 14112-14116 (2013).
-
(2013)
Angew. Chem. Int. Ed.
, vol.52
, pp. 14112-14116
-
-
Versteegen, R.M.1
Rossin, R.2
Ten Hoeve, W.3
Janssen, H.M.4
Robillard, M.S.5
-
72
-
-
84894148049
-
Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells
-
Nguyen, D. P. et al. Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells. J. Am. Chem. Soc. 136, 2240-2243 (2014).
-
(2014)
J. Am. Chem. Soc.
, vol.136
, pp. 2240-2243
-
-
Nguyen, D.P.1
-
73
-
-
84864276237
-
Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine
-
Arbely, E., Torres-Kolbus, J., Deiters, A. & Chin, J. W. Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine. J. Am. Chem. Soc. 134, 11912-11915 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 11912-11915
-
-
Arbely, E.1
Torres-Kolbus, J.2
Deiters, A.3
Chin, J.W.4
-
74
-
-
33847648384
-
Genetic incorporation of unnatural amino acids into proteins in mammalian cells
-
Liu, W., Brock, A., Chen, S., Chen, S. & Schultz, P. G. Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nature Methods 4, 239-244 (2007).
-
(2007)
Nature Methods
, vol.4
, pp. 239-244
-
-
Liu, W.1
Brock, A.2
Chen, S.3
Chen, S.4
Schultz, P.G.5
-
75
-
-
84894192194
-
Making sense of nonsense
-
Goodman, C. Making sense of nonsense. Nature Chem. Biol. 10, 167-167 (2014).
-
(2014)
Nature Chem. Biol.
, vol.10
, pp. 167
-
-
Goodman, C.1
|