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Volumn 2, Issue 9, 2011, Pages 1666-1676

Methods for converting cysteine to dehydroalanine on peptides and proteins

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL CONVERSIONS; GENERAL METHOD; GLYCOSYLATED; MULTIPLE METHODS; PROTEIN MODIFICATIONS; SIDE REACTIONS; SITE SELECTIVE; SYNTHETIC PRECURSORS;

EID: 81355138529     PISSN: 20416520     EISSN: 20416539     Source Type: Journal    
DOI: 10.1039/c1sc00185j     Document Type: Article
Times cited : (285)

References (96)
  • 62
    • 3042934967 scopus 로고
    • See Electronic Supplementary Information for full details
    • G. L. Ellman Arch. Biochem. Biophys. 1959 82 70 77
    • (1959) Arch. Biochem. Biophys. , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 74
    • 64149109414 scopus 로고    scopus 로고
    • Since 22 was synthesized as a mixture of meso and d/l, alkyation and cyclization will result in diastereomeric intermediates before converging to the dehydroalanine product. Though the rate of bis-alkylation and elimination of these diastereomers may differ, the good yields in model systems and high conversions on protein substrates suggest that any difference in these rates is not detrimental to the synthesis of dehydroalanine
    • R. Okamoto S. Souma Y. Kajihara J. Org. Chem. 2009 74 2494 2501
    • (2009) J. Org. Chem. , vol.74 , pp. 2494-2501
    • Okamoto, R.1    Souma, S.2    Kajihara, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.