-
1
-
-
84861986053
-
Wnt/beta-catenin signaling and disease
-
Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192-1205 (2012
-
(2012)
Cell
, vol.149
, pp. 1192-1205
-
-
Clevers, H.1
Nusse, R.2
-
2
-
-
84861699364
-
The adenomatous polyposis coli tumour suppressor is essential for axin complex assembly and function and opposes axin's interaction with dishevelled
-
Mendoza-Topaz, C., Mieszczanek, J. & Bienz, M. The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. Open Biol. 1, 110013 (2011
-
(2011)
Open Biol
, vol.1
, pp. 110013
-
-
Mendoza-Topaz, C.1
Mieszczanek, J.2
Bienz, M.3
-
3
-
-
67650230896
-
Wnt/beta-catenin signaling: Components, mechanisms, and diseases
-
MacDonald, B. T., Tamai, K. & He, X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17, 9-26 (2009
-
(2009)
Dev. Cell
, vol.17
, pp. 9-26
-
-
Macdonald, B.T.1
Tamai, K.2
He, X.3
-
4
-
-
34250827150
-
Wnt induces lrp6 signalosomes and promotes dishevelleddependent lrp6 phosphorylation
-
Bilic, J. et al. Wnt induces LRP6 signalosomes and promotes dishevelleddependent LRP6 phosphorylation. Science 316, 1619-1622 (2007
-
(2007)
Science
, vol.316
, pp. 1619-1622
-
-
Bilic, J.1
-
5
-
-
34249890531
-
The dix domain of dishevelled confers wnt signaling by dynamic polymerization
-
Schwarz-Romond, T. et al. The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nature Struct. Mol. Biol. 14, 484-492 (2007
-
(2007)
Nature Struct. Mol. Biol
, vol.14
, pp. 484-492
-
-
Schwarz-Romond, T.1
-
6
-
-
84918528755
-
Signalosome assembly by domains undergoing dynamic head-to-tail polymerization
-
Bienz, M. Signalosome assembly by domains undergoing dynamic head-to-tail polymerization. Trends Biochem. Sci. 39, 487-495 (2014
-
(2014)
Trends Biochem. Sci
, vol.39
, pp. 487-495
-
-
Bienz, M.1
-
7
-
-
79952148045
-
Dishevelled interacts with the dix domain polymerization interface of axin to interfere with its function in down-regulating b-catenin
-
Fiedler, M., Mendoza-Topaz, C., Rutherford, T. J., Mieszczanek, J. & Bienz, M. Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating b-catenin. Proc. Natl Acad. Sci. USA 108, 1937-1942 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 1937-1942
-
-
Fiedler, M.1
Mendoza-Topaz, C.2
Rutherford, T.J.3
Mieszczanek, J.4
Bienz, M.5
-
8
-
-
0037513408
-
A role of dishevelled in relocating axin to the plasma membrane during wingless signaling
-
Cliffe, A., Hamada, F. & Bienz, M. A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling. Curr. Biol. 13, 960-966 (2003
-
(2003)
Curr. Biol
, vol.13
, pp. 960-966
-
-
Cliffe, A.1
Hamada, F.2
Bienz, M.3
-
9
-
-
84898749421
-
Structural basis of gsk-3 inhibition by n-terminal phosphorylation and by the wnt receptor lrp6
-
Stamos, J. L., Chu, M. L., Enos, M. D., Shah, N. &Weis, W. I. Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. eLife 3, e01998 (2014
-
(2014)
ELife
, vol.3
, pp. e01998
-
-
Stamos, J.L.1
Chu, M.L.2
Enos, M.D.3
Shah, N.4
Weis, W.I.5
-
10
-
-
33845355511
-
Diversity of lef/tcf action in development and disease
-
Arce, L., Yokoyama, N. N. & Waterman, M. L. Diversity of LEF/TCF action in development and disease. Oncogene 25, 7492-7504 (2006
-
(2006)
Oncogene
, vol.25
, pp. 7492-7504
-
-
Arce, L.1
Yokoyama, N.N.2
Waterman, M.L.3
-
11
-
-
79953155959
-
Molecular basis of wnt activation via the dix domain protein ccd1
-
Liu, Y. T. et al. Molecular basis of Wnt activation via the DIX domain protein Ccd1. J. Biol. Chem. 286, 8597-8608 (2011
-
(2011)
J. Biol. Chem
, vol.286
, pp. 8597-8608
-
-
Liu, Y.T.1
-
12
-
-
29244462476
-
The wnt signalling effector dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
-
Schwarz-Romond, T., Merrifield, C., Nichols, B. J. & Bienz, M. The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J. Cell Sci. 118, 5269-5277 (2005
-
(2005)
J. Cell Sci
, vol.118
, pp. 5269-5277
-
-
Schwarz-Romond, T.1
Merrifield, C.2
Nichols, B.J.3
Bienz, M.4
-
13
-
-
84871921766
-
100 Years of lewy pathology
-
Goedert, M., Spillantini, M. G., Del Tredici, K. & Braak, H. 100 years of Lewy pathology. Nat. Rev. Neurol. 9, 13-24 (2013
-
(2013)
Nat. Rev. Neurol
, vol.9
, pp. 13-24
-
-
Goedert, M.1
Spillantini, M.G.2
Del Tredici, K.3
Braak, H.4
-
14
-
-
84897128080
-
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the wnt signaling pathway
-
de Groot, R. E. et al. Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway. Sci. Signal. 7, ra26 (2014
-
(2014)
Sci. Signal
, vol.7
, pp. ra26
-
-
De Groot, R.E.1
-
15
-
-
77649259009
-
Loss of the tumor suppressor cyld enhances wnt/bcatenin signaling through k63-linked ubiquitination of dvl
-
Tauriello, D. V. et al. Loss of the tumor suppressor CYLD enhances Wnt/bcatenin signaling through K63-linked ubiquitination of Dvl. Mol. Cell 37, 607-619 (2010
-
(2010)
Mol. Cell
, vol.37
, pp. 607-619
-
-
Tauriello, D.V.1
-
16
-
-
84883185607
-
Deubiquitination of dishevelled by usp14 is required for wnt signaling
-
Jung, H. et al. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Oncogenesis 2, e64 (2013
-
(2013)
Oncogenesis
, vol.2
, pp. e64
-
-
Jung, H.1
-
17
-
-
84555218153
-
The differential modulation of usp activity by internal regulatory domains, interactors and eight ubiquitin chain types
-
Faesen, A. C. et al. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chem. Biol. 18, 1550-1561 (2011
-
(2011)
Chem. Biol
, vol.18
, pp. 1550-1561
-
-
Faesen, A.C.1
-
18
-
-
39549106692
-
The structure of the cyld usp domain explains its specificity for lys63-linked polyubiquitin and reveals a b box module
-
Komander, D. et al. The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol. Cell 29, 451-464 (2008
-
(2008)
Mol. Cell
, vol.29
, pp. 451-464
-
-
Komander, D.1
-
19
-
-
77956903406
-
Engineered diubiquitin synthesis reveals lys29-isopeptide specificity of an otu deubiquitinase
-
Virdee, S., Ye, Y., Nguyen, D. P., Komander, D. & Chin, J. W. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nat. Chem. Biol. 6, 750-757 (2010
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 750-757
-
-
Virdee, S.1
Ye, Y.2
Nguyen, D.P.3
Komander, D.4
Chin, J.W.5
-
20
-
-
80455123843
-
Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme
-
Castaneda, C. et al. Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme. J. Am. Chem. Soc. 133, 17855-17868 (2011
-
(2011)
J. Am. Chem. Soc
, vol.133
, pp. 17855-17868
-
-
Castaneda, C.1
-
21
-
-
84902207255
-
Nonenzymatic rubylation and ubiquitination of proteins for structural and functional studies
-
Singh, R. K., Sundar, A. & Fushman, D. Nonenzymatic rubylation and ubiquitination of proteins for structural and functional studies. Angew. Chem. Int. Ed. Engl. 53, 6120-6125 (2014
-
(2014)
Angew. Chem. Int. Ed. Engl
, vol.53
, pp. 6120-6125
-
-
Singh, R.K.1
Sundar, A.2
Fushman, D.3
-
22
-
-
77955417276
-
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase cezanne
-
Bremm, A., Freund, S. M. & Komander, D. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nature Struct. Mol. Biol. 17, 939-947 (2010
-
(2010)
Nature Struct. Mol. Biol
, vol.17
, pp. 939-947
-
-
Bremm, A.1
Freund, S.M.2
Komander, D.3
-
23
-
-
0033397158
-
Polypeptide synthesis by the thioester method
-
Aimoto, S. Polypeptide synthesis by the thioester method. Biopolymers 51, 247-265 (1999
-
(1999)
Biopolymers
, vol.51
, pp. 247-265
-
-
Aimoto, S.1
-
24
-
-
34250880139
-
Auxiliary-mediated site-specific peptide ubiquitylation
-
Chatterjee, C., McGinty, R. K., Pellois, J. P. & Muir, T. W. Auxiliary-mediated site-specific peptide ubiquitylation. Angew. Chem. Int. Ed. Engl. 46, 2814-2818 (2007
-
(2007)
Angew. Chem. Int. Ed. Engl
, vol.46
, pp. 2814-2818
-
-
Chatterjee, C.1
McGinty, R.K.2
Pellois, J.P.3
Muir, T.W.4
-
25
-
-
33748620928
-
Ruthenium-induced allylcarbamate cleavage in living cells
-
Streu, C. & Meggers, E. Ruthenium-induced allylcarbamate cleavage in living cells. Angew. Chem. Int. Ed. Engl. 45, 5645-5648 (2006
-
(2006)
Angew. Chem. Int. Ed. Engl
, vol.45
, pp. 5645-5648
-
-
Streu, C.1
Meggers, E.2
-
26
-
-
77954903507
-
Balanced ubiquitylation and deubiquitylation of frizzled regulate cellular responsiveness to wg/wnt
-
Mukai, A. et al. Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt. EMBO J. 29, 2114-2125 (2010
-
(2010)
EMBO J
, vol.29
, pp. 2114-2125
-
-
Mukai, A.1
-
27
-
-
39449084931
-
Trabid a new positive regulator of wnt-induced transcription with preference for binding and cleaving k63-linked ubiquitin chains
-
Tran, H., Hamada, F., Schwarz-Romond, T. & Bienz, M. Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22, 528-542 (2008
-
(2008)
Genes Dev
, vol.22
, pp. 528-542
-
-
Tran, H.1
Hamada, F.2
Schwarz-Romond, T.3
Bienz, M.4
-
28
-
-
67349231313
-
Molecular discrimination of structurally equivalent lys 63-linked and linear polyubiquitin chains
-
Komander, D. et al. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 10, 466-473 (2009
-
(2009)
EMBO Rep
, vol.10
, pp. 466-473
-
-
Komander, D.1
-
29
-
-
84878832998
-
Otu deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
-
Mevissen, T. E. et al. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154, 169-184 (2013
-
(2013)
Cell
, vol.154
, pp. 169-184
-
-
Mevissen, T.E.1
-
30
-
-
50349102579
-
Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase t
-
Reyes-Turcu, F. E., Shanks, J. R., Komander, D. &Wilkinson, K. D. Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J. Biol. Chem. 283, 19581-19592 (2008
-
(2008)
J. Biol. Chem
, vol.283
, pp. 19581-19592
-
-
Reyes-Turcu, F.E.1
Shanks, J.R.2
Komander, D.3
Wilkinson, K.D.4
-
31
-
-
77956527159
-
Enhancement of proteasome activity by a small-molecule inhibitor of usp14
-
Lee, B. H. et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467, 179-184 (2010
-
(2010)
Nature
, vol.467
, pp. 179-184
-
-
Lee, B.H.1
-
32
-
-
79955470830
-
Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes
-
Lee, M. J., Lee, B. H., Hanna, J., King, R. W. & Finley, D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol. Cell. Proteomics 10, R110.003871 (2011
-
(2011)
Mol. Cell. Proteomics
, vol.10
, pp. R110003871
-
-
Lee, M.J.1
Lee, B.H.2
Hanna, J.3
King, R.W.4
Finley, D.5
-
33
-
-
84859142134
-
Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation
-
Meier, F. et al. Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation. J. Am. Chem. Soc. 134, 5468-5471 (2012
-
(2012)
J. Am. Chem. Soc
, vol.134
, pp. 5468-5471
-
-
Meier, F.1
-
34
-
-
78650866766
-
Towards elucidation of the role of ubiquitination in the pathogenesis of parkinson's disease with semisynthetic ubiquitinated a-synuclein
-
Hejjaoui, M., Haj-Yahya, M., Kumar, K. S., Brik, A. & Lashuel, H. A. Towards elucidation of the role of ubiquitination in the pathogenesis of Parkinson's disease with semisynthetic ubiquitinated a-synuclein. Angew. Chem. Int. Ed. Engl. 50, 405-409 (2011
-
(2011)
Angew. Chem. Int. Ed. Engl
, vol.50
, pp. 405-409
-
-
Hejjaoui, M.1
Haj-Yahya, M.2
Kumar, K.S.3
Brik, A.4
Lashuel, H.A.5
-
35
-
-
84887102319
-
Synthetic polyubiquitinated a-synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
-
Haj-Yahya, M. et al. Synthetic polyubiquitinated a-synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proc. Natl Acad. Sci. USA 110, 17726-17731 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 17726-17731
-
-
Haj-Yahya, M.1
-
36
-
-
84893848639
-
Cyld regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-numa-dynein/dynactin complex formation
-
Yang, Y. et al. CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc. Natl Acad. Sci. USA 111, 2158-2163 (2014
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 2158-2163
-
-
Yang, Y.1
-
37
-
-
84883740585
-
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of otub1
-
Wiener, R. et al. E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1. Nature Struct. Mol. Biol. 20, 1033-1039 (2013
-
(2013)
Nature Struct. Mol. Biol
, vol.20
, pp. 1033-1039
-
-
Wiener, R.1
-
38
-
-
52149103164
-
Structural basis for specific cleavage of lys 63-linked polyubiquitin chains
-
Sato, Y. et al. Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature 455, 358-362 (2008
-
(2008)
Nature
, vol.455
, pp. 358-362
-
-
Sato, Y.1
-
39
-
-
84878862687
-
Otulin antagonizes lubac signaling by specifically hydrolyzing met1-linked polyubiquitin
-
Keusekotten, K. et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell 153, 1312-1326 (2013
-
(2013)
Cell
, vol.153
, pp. 1312-1326
-
-
Keusekotten, K.1
-
40
-
-
84879834151
-
Unique structural, dynamical, and functional properties of k11-linked polyubiquitin chains
-
Castaneda, C. A., Kashyap, T. R., Nakasone, M. A., Krueger, S. & Fushman, D. Unique structural, dynamical, and functional properties of K11-linked polyubiquitin chains. Structure 21, 1168-1181 (2013
-
(2013)
Structure
, vol.21
, pp. 1168-1181
-
-
Castaneda, C.A.1
Kashyap, T.R.2
Nakasone, M.A.3
Krueger, S.4
Fushman, D.5
-
41
-
-
23044484731
-
Various strategies of using residual dipolar couplings in nmr-driven protein docking: Application to lys48-linked di-ubiquitin and validation against 15n-relaxation data
-
van Dijk, A. D., Fushman, D. & Bonvin, A. M. Various strategies of using residual dipolar couplings in NMR-driven protein docking: application to Lys48-linked di-ubiquitin and validation against 15N-relaxation data. Proteins 60, 367-381 (2005
-
(2005)
Proteins
, vol.60
, pp. 367-381
-
-
Van Dijk, A.D.1
Fushman, D.2
Bonvin, A.M.3
-
42
-
-
44849100496
-
Chemically ubiquitylated histone h2b stimulates hdot1l-mediated intranucleosomal methylation
-
McGinty, R. K., Kim, J., Chatterjee, C., Roeder, R. G. & Muir, T. W. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature 453, 812-816 (2008
-
(2008)
Nature
, vol.453
, pp. 812-816
-
-
McGinty, R.K.1
Kim, J.2
Chatterjee, C.3
Roeder, R.G.4
Muir, T.W.5
-
43
-
-
77951241293
-
Chemical approaches for studying histone modifications
-
Chatterjee, C. & Muir, T. W. Chemical approaches for studying histone modifications. J. Biol. Chem. 285, 11045-11050 (2010
-
(2010)
J. Biol. Chem
, vol.285
, pp. 11045-11050
-
-
Chatterjee, C.1
Muir, T.W.2
-
44
-
-
78751515133
-
Histone h2b ubiquitylation disrupts local and higher-order chromatin compaction
-
Fierz, B. et al. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nat. Chem. Biol. 7, 113-119 (2011
-
(2011)
Nat. Chem. Biol
, vol.7
, pp. 113-119
-
-
Fierz, B.1
-
45
-
-
77949875253
-
Chemically ubiquitylated pcna as a probe for eukaryotic translesion dna synthesis
-
Chen, J., Ai, Y., Wang, J., Haracska, L. & Zhuang, Z. Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis. Nat. Chem. Biol. 6, 270-272 (2010
-
(2010)
Nat. Chem. Biol
, vol.6
, pp. 270-272
-
-
Chen, J.1
Ai, Y.2
Wang, J.3
Haracska, L.4
Zhuang, Z.5
-
46
-
-
40949099577
-
Genetically encoding ne-acetyllysine in recombinant proteins
-
Neumann, H., Peak-Chew, S. Y. & Chin, J. W. Genetically encoding Ne-acetyllysine in recombinant proteins. Nat. Chem. Biol. 4, 232-234 (2008
-
(2008)
Nat. Chem. Biol
, vol.4
, pp. 232-234
-
-
Neumann, H.1
Peak-Chew, S.Y.2
Chin, J.W.3
-
47
-
-
43449132666
-
Decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex
-
Fiedler, M. et al. Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol. Cell 30, 507-518 (2008
-
(2008)
Mol. Cell
, vol.30
, pp. 507-518
-
-
Fiedler, M.1
-
48
-
-
84907358982
-
Screening of dub activity and specificity by maldi-tof mass spectrometry
-
Ritorto, M. S. et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat. Commun. 5, 4763 (2014).
-
(2014)
Nat. Commun
, vol.5
, pp. 4763
-
-
Ritorto, M.S.1
|