Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice

International Immunopharmacology

Volumn 19, Issue 2, 2014, Pages 351-357

  Bai, Ting ^a   Yang, Yong ^a   Wu, Yan Ling ^a   Jiang, Shuang ^a   Lee, Jung Joon ^a   Lian, Li Hua ^a   Nan, Ji Xing ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

AMPK; Hepatic fibrosis; LKB1; PI3K; Thymoquinone

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LKB1; SCLEROPROTEIN; THIOACETAMIDE; THYMOQUINONE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTI FIBROSIS ACTIVITY; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THIOACETAMIDE-INDUCED LIVER FIBROSIS;

AMPK; HEPATIC FIBROSIS; LKB1; PI3K; THYMOQUINONE;

ACTINS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; COLLAGEN TYPE I; CYTOKINES; LIVER; LIVER CIRRHOSIS; MALE; MICE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; THIOACETAMIDE; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84895556660     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.02.006     Document Type: Article

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