Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling

Toxicology

Volumn 280, Issue 3, 2011, Pages 152-163

  Szuster Ciesielska, Agnieszka ^a   Plewka, Krzysztof ^a   Daniluk, Jadwiga ^b   Kandefer Szerszeń, Martyna ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Betulin; Betulinic acid; Cytokines; Ethanol; Liver stellate cells; MAPK; MMPs; NF B; TIMPs

Indexed keywords

ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; BETULIC ACID; BETULIN; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ATTENUATION; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVITY; IN VITRO STUDY; INHIBITION KINETICS; INTRACELLULAR SIGNALING; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CELL LINE; ETHANOL; HEPATIC STELLATE CELLS; INTRACELLULAR FLUID; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 79151477517     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.12.006     Document Type: Article

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