Simvastatin impairs insulin secretion by multiple mechanisms in MIN6 cells

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Yaluri, Nagendra ^a   Modi, Shalem ^a   Rodríguez, Maykel López ^a   Stancáková, Alena ^a   Kuusisto, Johanna ^a,b   Kokkola, Tarja ^a   Laakso, Markku ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCIUM ION; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR 40; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; MUSCARINIC M3 RECEPTOR; PRAVASTATIN; SIMVASTATIN; VOLTAGE GATED CALCIUM CHANNEL; ADENOSINE TRIPHOSPHATE; CALCIUM; FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GPR119 PROTEIN, MOUSE; GPR40 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG TARGETING; ENDOCRINE DISEASE; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; MIN6 CELL LINE; MOUSE; NONHUMAN; PANCREAS CELL; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; BLOOD; CELL LINE; CHEMISTRY; DRUG EFFECTS; ERYTHROCYTE MEMBRANE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; PANCREAS; RISK FACTOR; SECRETION (PROCESS);

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL LINE; COLFORSIN; CYCLIC AMP; DIABETES MELLITUS; ERYTHROCYTE MEMBRANE; FATTY ACIDS; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSULIN; MALE; METABOLIC SYNDROME X; MICE; MIDDLE AGED; PANCREAS; PRAVASTATIN; RECEPTORS, G-PROTEIN-COUPLED; RISK FACTORS; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 84955457469     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0142902     Document Type: Article

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