Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 5, 2014, Pages 1649-1666

  Sato, Kenjiro ^a   Sugimoto, Hiromichi ^a   Rikimaru, Kentaro ^a   Imoto, Hiroshi ^a   Kamaura, Masahiro ^a   Negoro, Nobuyuki ^a   Tsujihata, Yoshiyuki ^a   Miyashita, Hirohisa ^a   Odani, Tomoyuki ^a   Murata, Toshiki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Conformation; GPCR; GPR119 agonist; Indoline; Type 2 diabetes mellitus

Indexed keywords

2 [1 (5 ETHYLPYRIMIDIN 2 YL)PIPERIDIN 4 YL]PROPYL 7 FLUORO 5 (METHYLSULFONYL) 2,3 DIHYDRO 1H INDOLE 1 CARBOXYLATE; 2 [1 (TERT BUTOXYCARBONYL)PIPERIDIN 4 YL]PROPYL 5 (METHYLSULFONYL) 2,3 DIHYDRO 1H INDOLE 1 CARBOXYLATE; 4 (2 HYDROXYETHYL)PIPERIDINE DERIVATIVE; 4 FLUORO 2,3 DIHYDRO 1H INDOLE; 4 FLUORO 5 (METHYLSULFANYL) 2,3 DIHYDRO 1H INDOLE; 4 METHYL 5 (METHYLSUFONYL) 2,3 DIHYDRO 1H INDOLE; 5 (METHYLSULFONYL) 1 [6 [[1 [3 (PROPAN 2 YL) 1,2,4 OXADIAZOL 5 YL]PIPERIDIN 4 YL]OXY]PYRIMIDIN 4 YL] 2,3 DIHYDRO 1H INDOLE; 5 (METHYLSULFONYL)INDOLINE; 6 FLUORO 2,3 DIHYDRO 1H INDOLE; 6 FLUORO 5 (METHYLSUFONYL) 2,3 DIHYDRO 1H INDOLE; 6 METHOXY 2,3 DIHYDRO 1H INDOLE; ANTIDIABETIC AGENT; BENZYL 4 (2 HYDROXYPROPYL)PIPERIDINE 1 CARBOXYLATE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; G PROTEIN COUPLED RECEPTOR 119 AGONIST; GLUCOSE; INDOLINE CARBAMATE DERIVATIVE; INDOLINYLPYRIMIDINE DERIVATIVE; INSULIN; LEAD; N ARYL INDOLINE DERIVATIVE; PYRROLO[2,3 D]PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; GPR119 PROTEIN, RAT; INDOLE DERIVATIVE; INDOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GLUCOSE TOLERANCE TEST; SYNTHESIS;

RATTUS;

ANIMALS; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; INDOLES; MOLECULAR STRUCTURE; RATS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896713258     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.01.028     Document Type: Article

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