Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

British Journal of Pharmacology

Volumn 155, Issue 7, 2008, Pages 1056-1065

  Ning, Y ^a   O'Neill, K ^a   Lan, H ^a   Pang, L ^a   Shan, L X ^a   Hawes, B E ^a   Hedrick, J A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Agonists; Calcium flux; cAMP; GLP 1; GPR119; Insulin secretion; Oleoylethanolamide

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; G PROTEIN COUPLED RECEPTOR 119 STIMULATING AGENT; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; LYSOPHOSPHATIDYLCHOLINE; N OLEOYLETHANOLAMINE; OLEOYLLYSOLECITHIN; PSN 375963; PSN 632408; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL LEVEL; CHANNEL GATING; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; INSULIN RELEASE; INSULINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR CELL;

ACIDS, HETEROCYCLIC; ANIMALS; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; CYCLIC AMP; GLUCOSE; INSULIN; INSULINOMA; KATP CHANNELS; LYSOPHOSPHATIDYLCHOLINES; MICE; OLEIC ACIDS; OXADIAZOLES; PYRIDONES; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 56749170734     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.337     Document Type: Article

References (22)

1. Astarita G, Di Giacomo B, Gaetani S, Oveisi F, Compton TR, Rivara S et al. (2006). Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther 318: 563-570.
2. Chan SL, Mourtada M, Morgan NG (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes 50: 340-347.
3. Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A et al. (2008). A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like peptide-1 and glucose-dependent insulinotropic peptide release. Endocrinology 149: 2038-2047.
4. Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A et al. (2007). A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology 148: 2601-2609.
5. Desvergne B, Wahli W (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20: 649-688.
6. Drucker DJ (2006). The biology of incretin hormones. Cell Metab 3: 153-165.
7. Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (2003). Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett 554: 381-388.
8. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez De Fonseca F et al. (2003). Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93.
9. Ganesan S, Calle R, Zawalich K, Greenawalt K, Zawalich W, Shulman GI et al. (1992). Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion. J Cell Biol 119: 313-324.
10. Guzman M, Lo Verme J, Fu J, Oveisi F, Blazquez C, Piomelli D (2004). Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). J Biol Chem 279: 27849-27854.
11. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ (2003). Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278: 471-478.
12. Light PE, Manning Fox JE, Riedel MJ, Wheeler MB (2002). Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Mol Endocrinol 16: 2135-2144.
13. McClenaghan NH, Flatt PR (1999). Engineering cultured insulin-secreting pancreatic B-cell lines. J Mol Med 77: 235-243.
14. Nielsen MJ, Petersen G, Astrup A, Hansen HS (2004). Food intake is inhibited by oral oleoylethanolamide. J Lipid Res 45: 1027-1029.
15. Ohno-Shosaku T, Yamamoto C (1992). Identification of an ATP-sensitive K+ channel in rat cultured cortical neurons. Pflugers Arch 422: 260-266.
16. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G et al. (2006). Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 3: 167-175.
17. Poitout V, Olson LK, Robertson RP (1996). Insulin-secreting cell lines: classification, characteristics and potential applications. Diabetes Metab 22: 7-14.
18. Proulx K, Cota D, Castaneda TR, Tschop MH, D'Alessio DA, Tso P et al. (2005). Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol 289: R729-R737.
19. Schroeder KS, Neagle BD (1996). FLIPR: a new instrument for accurate, high throughput optical screening. J Biomol Screen 1: 75-80.
20. Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J et al. (2005). Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun 326: 744-751.
21. Tsuboi T, da Silva Xavier G, Holz GG, Jouaville LS, Thomas AP, Rutter GA (2003). Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells. Biochem J 369: 287-299.
22. Zawalich WS, Zawalich KC (1992). Biochemical mechanisms involved in monomethyl succinate-induced insulin secretion. Endocrinology 131: 649-654.