-
1
-
-
84858276725
-
Epigenetics of colorectal cancer
-
Migheli F, Migliore L (2012) Epigenetics of colorectal cancer. Clin Genet 8:312–318.
-
(2012)
Clin Genet
, vol.8
, pp. 312-318
-
-
Migheli, F.1
Migliore, L.2
-
2
-
-
79954435158
-
Colorectal cancer epigenetics: Complex simplicity
-
van Engeland M, Derks S, Smits KM, Meijer GA, Herman JG (2011) Colorectal cancer epigenetics: complex simplicity. J Clin Oncol 29:1382–1391.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1382-1391
-
-
Van Engeland, M.1
Derks, S.2
Smits, K.M.3
Meijer, G.A.4
Herman, J.G.5
-
3
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell 150:12–27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
5
-
-
84882946044
-
Cancer stem cells in colorectal cancer: Genetic and epigenetic changes
-
Roy S, Majumdar AP (2012) Cancer stem cells in colorectal cancer: genetic and epigenetic changes. J. Stem Cell Res. Ther. Suppl 7(6): 10342.
-
(2012)
J. Stem Cell Res. Ther. Suppl
, vol.7
, Issue.6
, pp. 10342
-
-
Roy, S.1
Majumdar, A.P.2
-
6
-
-
84863770814
-
Cancer genetics and epigenetics: Two sides of the same coin?
-
You JS, Jones PA (2012) Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 22:9–20.
-
(2012)
Cancer Cell
, vol.22
, pp. 9-20
-
-
You, J.S.1
Jones, P.A.2
-
7
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429:457–463.
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
9
-
-
73549085850
-
DNAmethylation: An introduction to the biology and the disease-associated changes of a promising biomarker
-
Tost J (2010) DNAmethylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Mol Biotechnol 44:71–81.
-
(2010)
Mol Biotechnol
, vol.44
, pp. 71-81
-
-
Tost, J.1
-
10
-
-
70350046301
-
Rethinking how DNA methylation patterns are maintained
-
Jones PA, Liang G (2009) Rethinking how DNA methylation patterns are maintained. Nat Rev Genet 10:805–811.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 805-811
-
-
Jones, P.A.1
Liang, G.2
-
11
-
-
0034625064
-
Non- CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
-
Ramsahoye BH, Biniszkiewicz D, Lyko F, Clark V, Bird A, Jaenisch R (2000) Non- CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A 97:5237–5242.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5237-5242
-
-
Ramsahoye, B.H.1
Biniszkiewicz, D.2
Lyko, F.3
Clark, V.4
Bird, A.5
Jaenisch, R.6
-
12
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister R, Pelizzola M, Dowen RH et al (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462:315–322.
-
(2009)
Nature
, vol.462
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
-
13
-
-
0142247187
-
Mammalian DNA (cytosine-5) methyltransferases and their expression
-
Pradhan S, Esteve PO (2003) Mammalian DNA (cytosine-5) methyltransferases and their expression. Clin Immunol 109:6–16.
-
(2003)
Clin Immunol
, vol.109
, pp. 6-16
-
-
Pradhan, S.1
Esteve, P.O.2
-
14
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99:247–257.
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
15
-
-
0035930660
-
Dnmt3L and the establishment of maternal genomic imprints
-
Bourc’his D, Xu GL, Lin CS, Bollman B, Bestor TH (2001) Dnmt3L and the establishment of maternal genomic imprints. Science 294:2536–2539.
-
(2001)
Science
, vol.294
, pp. 2536-2539
-
-
Bourc’his, D.1
Xu, G.L.2
Lin, C.S.3
Bollman, B.4
Bestor, T.H.5
-
16
-
-
34548603504
-
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
-
Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X (2007) Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 449:248–251.
-
(2007)
Nature
, vol.449
, pp. 248-251
-
-
Jia, D.1
Jurkowska, R.Z.2
Zhang, X.3
Jeltsch, A.4
Cheng, X.5
-
17
-
-
53649097070
-
Recognition of hemimethylated DNA by the SRA protein UHRF1 by a base-fl ipping mechanism
-
Arita K, Ariyoshi M, Tochio H, Nakamura Y, Shirakawa M (2008) Recognition of hemimethylated DNA by the SRA protein UHRF1 by a base-fl ipping mechanism. Nature 455: 818–821.
-
(2008)
Nature
, vol.455
, pp. 818-821
-
-
Arita, K.1
Ariyoshi, M.2
Tochio, H.3
Nakamura, Y.4
Shirakawa, M.5
-
18
-
-
34648833002
-
UHRF1 plays a role in maintaining DNA methylation in mammalian cells
-
Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317:1760–1764.
-
(2007)
Science
, vol.317
, pp. 1760-1764
-
-
Bostick, M.1
Kim, J.K.2
Estève, P.O.3
Clark, A.4
Pradhan, S.5
Jacobsen, S.E.6
-
19
-
-
70349322609
-
Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA
-
Jeong S, Liang G, Sharma S, Lin JC, Choi SH, Han H, Yoo CB, Egger G, Yang AS, Jones PA (2009) Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol 29:5366–5376.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5366-5376
-
-
Jeong, S.1
Liang, G.2
Sharma, S.3
Lin, J.C.4
Choi, S.H.5
Han, H.6
Yoo, C.B.7
Egger, G.8
Yang, A.S.9
Jones, P.A.10
-
20
-
-
33847076849
-
Chromatin modifi cations and their function
-
Kouzarides T (2007) Chromatin modifi cations and their function. Cell 128:693–705.
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
21
-
-
84862773672
-
Epigenetics offer new horizons for colorectal cancer prevention
-
Schnekenburger M, Diederich M (2012) Epigenetics offer new horizons for colorectal cancer prevention. Curr Colorectal Cancer Rep 8:66–81.
-
(2012)
Curr Colorectal Cancer Rep
, vol.8
, pp. 66-81
-
-
Schnekenburger, M.1
Diederich, M.2
-
22
-
-
84877928408
-
Epigenetic regulation of colon cancer and intestinal stem cells
-
Hammoud SS, Cairns BR, Jones DA (2013) Epigenetic regulation of colon cancer and intestinal stem cells. Curr Opin Cell Biol 25: 177–183.
-
(2013)
Curr Opin Cell Biol
, vol.25
, pp. 177-183
-
-
Hammoud, S.S.1
Cairns, B.R.2
Jones, D.A.3
-
23
-
-
67650462249
-
DNA hypomethylation in the origin and pathogenesis of human diseases
-
Pogribny IP, Beland FA (2009) DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci 66: 2249–2261.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 2249-2261
-
-
Pogribny, I.P.1
Beland, F.A.2
-
24
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modifi cation maps
-
Esteller M (2007) Cancer epigenomics: DNA methylomes and histone-modifi cation maps. Nat Rev Genet 8:286–298.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 286-298
-
-
Esteller, M.1
-
25
-
-
51649083501
-
A microRNA DNA methylation signature for human cancer metastasis
-
Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M (2008) A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A 105:13556–13561.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13556-13561
-
-
Lujambio, A.1
Calin, G.A.2
Villanueva, A.3
Ropero, S.4
Sánchez-céspedes, M.5
Blanco, D.6
Montuenga, L.M.7
Rossi, S.8
Nicoloso, M.S.9
Faller, W.J.10
Gallagher, W.M.11
Eccles, S.A.12
Croce, C.M.13
Esteller, M.14
-
26
-
-
33744805399
-
Specifi c activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin modifying drugs in human cancer cells
-
Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA (2006) Specifi c activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin modifying drugs in human cancer cells. Cancer Cell 9:435–443.
-
(2006)
Cancer Cell
, vol.9
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
Friedman, J.M.4
Chuang, J.C.5
Coetzee, G.A.6
Jones, P.A.7
-
27
-
-
38349135680
-
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
-
Rauch TA, Zhong X, Wu X, Wang M, Kernstine KH, Wang Z, Riggs AD, Pfeifer GP (2008) High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc Natl Acad Sci U S A 105: 252–257.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 252-257
-
-
Rauch, T.A.1
Zhong, X.2
Wu, X.3
Wang, M.4
Kernstine, K.H.5
Wang, Z.6
Riggs, A.D.7
Pfeifer, G.P.8
-
28
-
-
70350720044
-
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
-
Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E, Fernandez H, Tallman MS, Greally JM, Carraway H, Licht JD, Gore SD, Melnick A (2009) MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood 114: 3448–3458.
-
(2009)
Blood
, vol.114
, pp. 3448-3458
-
-
Figueroa, M.E.1
Skrabanek, L.2
Li, Y.3
Jiemjit, A.4
Fandy, T.E.5
Paietta, E.6
Fernandez, H.7
Tallman, M.S.8
Greally, J.M.9
Carraway, H.10
Licht, J.D.11
Gore, S.D.12
Melnick, A.13
-
29
-
-
0347622294
-
Targeting DNA methylation in cancer
-
Szyf M (2003) Targeting DNA methylation in cancer. Ageing Res Rev 2:299–328.
-
(2003)
Ageing Res Rev
, vol.2
, pp. 299-328
-
-
Szyf, M.1
-
30
-
-
0038576158
-
The power and the promise of DNA methylation markers
-
Laird PW (2003) The power and the promise of DNA methylation markers. Nat Rev Cancer 3:253–266.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 253-266
-
-
Laird, P.W.1
-
31
-
-
55949113233
-
Use of DNA methylation for cancer detection: Promises and challenges
-
Zhu J, Yao X (2009) Use of DNA methylation for cancer detection: promises and challenges. Int J Biochem Cell Biol 41:147–154.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 147-154
-
-
Zhu, J.1
Yao, X.2
-
32
-
-
66149118937
-
The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer
-
Shah R, Smith P, Purdie C, Quinlan P, Baker L, Aman P, Thompson AM, Crook T (2009) The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer. Br J Cancer 100: 1687–1696.
-
(2009)
Br J Cancer
, vol.100
, pp. 1687-1696
-
-
Shah, R.1
Smith, P.2
Purdie, C.3
Quinlan, P.4
Baker, L.5
Aman, P.6
Thompson, A.M.7
Crook, T.8
-
33
-
-
67349175004
-
Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease
-
Mayor R, Casadome L, Azuara D, Moreno V, Clark SJ, Capella G, Peinado MA (2009) Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of disease. Br J Cancer 100: 1534–1539.
-
(2009)
Br J Cancer
, vol.100
, pp. 1534-1539
-
-
Mayor, R.1
Casadome, L.2
Azuara, D.3
Moreno, V.4
Clark, S.J.5
Capella, G.6
Peinado, M.A.7
-
34
-
-
67650077151
-
Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
-
deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grützmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Day R, Sledziewski AZ, Lofton- Day C (2009) Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin Chem 55:1337–1346.
-
(2009)
Clin Chem
, vol.55
, pp. 1337-1346
-
-
Devos, T.1
Tetzner, R.2
Model, F.3
Weiss, G.4
Schuster, M.5
Distler, J.6
Steiger, K.V.7
Grützmann, R.8
Pilarsky, C.9
Habermann, J.K.10
Fleshner, P.R.11
Oubre, B.M.12
Day, R.13
Sledziewski, A.Z.14
Lofton- Day, C.15
-
36
-
-
25444491234
-
DNA methylation and demethylation as targets for anticancer therapy
-
Szyf M (2005) DNA methylation and demethylation as targets for anticancer therapy. Biochemistry 70:533–549.
-
(2005)
Biochemistry
, vol.70
, pp. 533-549
-
-
Szyf, M.1
-
37
-
-
0038747956
-
Relevance of DNA methylation in the management of cancer
-
Esteller M (2003) Relevance of DNA methylation in the management of cancer. Lancet Oncol 4:351–358.
-
(2003)
Lancet Oncol
, vol.4
, pp. 351-358
-
-
Esteller, M.1
-
38
-
-
65249157050
-
Epigenetics, DNA methylation, and chromatin modifying drugs
-
Szyf M (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49:243–263.
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 243-263
-
-
Szyf, M.1
-
39
-
-
34250638678
-
DNA methyltransferase inhibitors for cancer therapy
-
Brueckner B, Kuck D, Lyko F (2007) DNA methyltransferase inhibitors for cancer therapy. Cancer J 13:17–22.
-
(2007)
Cancer J
, vol.13
, pp. 17-22
-
-
Brueckner, B.1
Kuck, D.2
Lyko, F.3
-
40
-
-
0036861629
-
DNA methyltransferase inhibitorsstate of the art
-
Goffi n J, Eisenhauer E (2002) DNA methyltransferase inhibitorsstate of the art. Ann Oncol 13:1699–1716.
-
(2002)
Ann Oncol
, vol.13
, pp. 1699-1716
-
-
Goffi N, J.1
Eisenhauer, E.2
-
41
-
-
0029190250
-
Thiopurine induced disturbance of DNA methylation in human malignant cells
-
De Abreu R, Lambooy L, Stet E, Vogels- Mentink T, van den Heuvel L (1995) Thiopurine induced disturbance of DNA methylation in human malignant cells. Adv Enzyme Regul 35:251–263.
-
(1995)
Adv Enzyme Regul
, vol.35
, pp. 251-263
-
-
De Abreu, R.1
Lambooy, L.2
Stet, E.3
Vogels- Mentink, T.4
Van Den Heuvel, L.5
-
42
-
-
17344367737
-
New anticancer strategies: Epigenetic therapies and biomarkers
-
Balch C, Montgomery JS, Paik H-I, Kim S, Huang TH-M, Nephew KP (2005) New anticancer strategies: epigenetic therapies and biomarkers. Front Biosci 10:1887–1931.
-
(2005)
Front Biosci
, vol.10
, pp. 1887-1931
-
-
Balch, C.1
Montgomery, J.S.2
Paik, H.-I.3
Kim, S.4
Huang, T.-M.5
Nephew, K.P.6
-
43
-
-
33645981241
-
CpG island methylation and histone modifi cations: Biology and clinical signifi cance
-
Esteller M (2006) CpG island methylation and histone modifi cations: biology and clinical signifi cance. Ernst Schering Res Found Workshop 57:115–126.
-
(2006)
Ernst Schering Res Found Workshop
, vol.57
, pp. 115-126
-
-
Esteller, M.1
-
45
-
-
33846796029
-
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt’s lymphoma Akata cells
-
Rao SP, Rechsteiner MP, Berger C, Sigrist JA, Nadal D, Bernasconi M (2007) Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt’s lymphoma Akata cells. Mol Cancer 6:3–8.
-
(2007)
Mol Cancer
, vol.6
, pp. 3-8
-
-
Rao, S.P.1
Rechsteiner, M.P.2
Berger, C.3
Sigrist, J.A.4
Nadal, D.5
Bernasconi, M.6
-
46
-
-
66249127951
-
A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
-
Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob, ST (2009) A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res 69:4277–4285.
-
(2009)
Cancer Res
, vol.69
, pp. 4277-4285
-
-
Datta, J.1
Ghoshal, K.2
Denny, W.A.3
Gamage, S.A.4
Brooke, D.G.5
Phiasivongsa, P.6
Redkar, S.7
Jacob, S.T.8
-
47
-
-
77951019398
-
Emerging anticancer therapeutic targets and the cardiovascular system: Is there cause for concern?
-
Peng X, Pentassuglia L, Sawyer DB (2010) Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern? Circ Res 106:1022–1034.
-
(2010)
Circ Res
, vol.106
, pp. 1022-1034
-
-
Peng, X.1
Pentassuglia, L.2
Sawyer, D.B.3
-
48
-
-
22244435605
-
Epigenetic reactivation of tumor suppressor genes by a novel smallmolecule inhibitor of human DNA methyltransferases
-
Brueckner B, Boy RG, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, Suhai S, Wiessler M, Lyko F (2005) Epigenetic reactivation of tumor suppressor genes by a novel smallmolecule inhibitor of human DNA methyltransferases. Cancer Res 65:6305–6311.
-
(2005)
Cancer Res
, vol.65
, pp. 6305-6311
-
-
Brueckner, B.1
Boy, R.G.2
Siedlecki, P.3
Musch, T.4
Kliem, H.C.5
Zielenkiewicz, P.6
Suhai, S.7
Wiessler, M.8
Lyko, F.9
-
49
-
-
78650084530
-
The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-ltryptophan), a potential epigenetic modulator
-
Braun J, Boittiaux I, Tilborg A, Lambert D, Wouters J (2010) The dicyclo-hexyl-amine salt of RG108 (N-phthalyl-ltryptophan), a potential epigenetic modulator. Acta Crystallogr Sect E Struct Rep Online 66:3175–3176.
-
(2010)
Acta Crystallogr Sect E Struct Rep Online
, vol.66
, pp. 3175-3176
-
-
Braun, J.1
Boittiaux, I.2
Tilborg, A.3
Lambert, D.4
Wouters, J.5
-
50
-
-
33645462696
-
Synthesis and in vitro evaluation of biotinylated RG108: A high affi nity compound for studying binding interactions with human DNA methyltransferases
-
Schirrmacher E, Beck C, Brueckner B, Schmitges F, Siedlecki P, Bartenstein P, Lyko F, Schirrmacher R (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affi nity compound for studying binding interactions with human DNA methyltransferases. Bioconjug Chem 17:261–266.
-
(2006)
Bioconjug Chem
, vol.17
, pp. 261-266
-
-
Schirrmacher, E.1
Beck, C.2
Brueckner, B.3
Schmitges, F.4
Siedlecki, P.5
Bartenstein, P.6
Lyko, F.7
Schirrmacher, R.8
-
51
-
-
74049094114
-
Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors
-
Suzuki T, Tanaka R, Hamada S, Nakagawa H, Miyata N (2010) Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors. Bioorg Med Chem Lett 20:1124–1127.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 1124-1127
-
-
Suzuki, T.1
Tanaka, R.2
Hamada, S.3
Nakagawa, H.4
Miyata, N.5
-
52
-
-
38949194522
-
Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy
-
Amato RJ (2007) Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy. Clin Genitourin Cancer 5:422–426.
-
(2007)
Clin Genitourin Cancer
, vol.5
, pp. 422-426
-
-
Amato, R.J.1
-
53
-
-
42249104213
-
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
-
Klisovic RB, Stock W, Cataland S, Klisovic MI, Liu S, Blum W, Green M, Odenike O, Godley L, Burgt JV, Van Laar E, Cullen M, Macleod AR, Besterman JM, Reid GK, Byrd JC, Marcucci G (2008) A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin Cancer Res 14:2444–2449.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2444-2449
-
-
Klisovic, R.B.1
Stock, W.2
Cataland, S.3
Klisovic, M.I.4
Liu, S.5
Blum, W.6
Green, M.7
Odenike, O.8
Godley, L.9
Burgt, J.V.10
Van Laar, E.11
Cullen, M.12
Macleod, A.R.13
Besterman, J.M.14
Reid, G.K.15
Byrd, J.C.16
Marcucci, G.17
-
54
-
-
33646595937
-
Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: A National Cancer Institute of Canada Clinical Trials Group investigational new drug study
-
Winquist E, Knox J, Ayoub JP, Wood L, Wainman N, Reid GK, Pearce L, Shah A, Eisenhauer E (2006) Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs 24:159–167.
-
(2006)
Invest New Drugs
, vol.24
, pp. 159-167
-
-
Winquist, E.1
Knox, J.2
Ayoub, J.P.3
Wood, L.4
Wainman, N.5
Reid, G.K.6
Pearce, L.7
Shah, A.8
Eisenhauer, E.9
-
55
-
-
65649152375
-
Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors
-
Plummer R, Vidal L, Griffi n M, Lesley M, de Bono J, Coulthard S, Sludden J, Siu LL, Chen EX, Oza AM, Reid GK, McLeod AR, Besterman JM, Lee C, Judson I, Calvert H, Boddy AV (2009) Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors. Clin Cancer Res 15:3177–3183.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3177-3183
-
-
Plummer, R.1
Vidal, L.2
Griffi N, M.3
Lesley, M.4
De Bono, J.5
Coulthard, S.6
Sludden, J.7
Siu, L.L.8
Chen, E.X.9
Oza, A.M.10
Reid, G.K.11
Mc leod, A.R.12
Besterman, J.M.13
Lee, C.14
Judson, I.15
Calvert, H.16
Boddy, A.V.17
-
56
-
-
1842411320
-
Crystal structure of the nucleosome core particle at 2.8 A resolution
-
Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:251–260.
-
(1997)
Nature
, vol.389
, pp. 251-260
-
-
Luger, K.1
Mader, A.W.2
Richmond, R.K.3
Sargent, D.F.4
Richmond, T.J.5
-
57
-
-
36448949026
-
Multivalent engagement of chromatin modifi cations by linked binding modules
-
Ruthenburg AJ, Li H, Patel DJ, Allis CD (2007) Multivalent engagement of chromatin modifi cations by linked binding modules. Nat Rev Mol Cell Biol 8:983–994.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 983-994
-
-
Ruthenburg, A.J.1
Li, H.2
Patel, D.J.3
Allis, C.D.4
-
58
-
-
0037087573
-
Specifi c targeting and constitutive association of histone deacetylase complexes during transcriptional repression
-
Li J, Lin Q, Wang W, Wade P, Wong J (2002) Specifi c targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes Dev 16: 687–692.
-
(2002)
Genes Dev
, vol.16
, pp. 687-692
-
-
Li, J.1
Lin, Q.2
Wang, W.3
Wade, P.4
Wong, J.5
-
59
-
-
0029856225
-
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
-
Rundlett SE, Carmen AA, Kobayashi R, Bavykin S, Turner BM, Grunstein M (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93:14503–14508.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14503-14508
-
-
Rundlett, S.E.1
Carmen, A.A.2
Kobayashi, R.3
Bavykin, S.4
Turner, B.M.5
Grunstein, M.6
-
60
-
-
1642580754
-
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
-
De Nadal E, Zapater M, Alepuz PM, Sumoy L, Mas G, Posas F (2004) The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature 427: 370–374.
-
(2004)
Nature
, vol.427
, pp. 370-374
-
-
De Nadal, E.1
Zapater, M.2
Alepuz, P.M.3
Sumoy, L.4
Mas, G.5
Posas, F.6
-
61
-
-
79954415619
-
Comprehensive lysine acetylomes emerging from bacteria to humans
-
Kim GW, Yang XJ (2011) Comprehensive lysine acetylomes emerging from bacteria to humans. Trends Biochem Sci 36:211–220.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 211-220
-
-
Kim, G.W.1
Yang, X.J.2
-
62
-
-
39749127166
-
The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
-
Yang XJ, Seto E (2008) The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9:206–218.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 206-218
-
-
Yang, X.J.1
Seto, E.2
-
63
-
-
52649169923
-
Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and infl ammatory diseases
-
Bonfi l C, Walkinshaw DR, Besterman JM, Yang XJ (2008) Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and infl ammatory diseases. Expert Opin Drug Discov 3:1041–1065.
-
(2008)
Expert Opin Drug Discov
, vol.3
, pp. 1041-1065
-
-
Bonfi L, C.1
Walkinshaw, D.R.2
Besterman, J.M.3
Yang, X.J.4
-
64
-
-
77649171884
-
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
-
Tan J, Cang S, Ma Y, Petrillo RL, Liu D (2010) Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J Hematol Oncol 3:5.
-
(2010)
J Hematol Oncol
, vol.3
, pp. 5
-
-
Tan, J.1
Cang, S.2
Ma, Y.3
Petrillo, R.L.4
Liu, D.5
-
65
-
-
77956898565
-
Recent advances in histone deacetylase targeted cancer therapy
-
Hoshino I, Matsubara H (2010) Recent advances in histone deacetylase targeted cancer therapy. Surg Today 40:809–815.
-
(2010)
Surg Today
, vol.40
, pp. 809-815
-
-
Hoshino, I.1
Matsubara, H.2
-
66
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1:287–299.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
67
-
-
13844309711
-
Clinical development of histone deacetylase inhibitors as anticancer agents
-
Drummond DC, Noble CO, Kirpotin DB, Guo Z, Scott GK, Benz CC (2005) Clinical development of histone deacetylase inhibitors as anticancer agents. Annu Rev Pharmacol Toxicol 45:495–528.
-
(2005)
Annu Rev Pharmacol Toxicol
, vol.45
, pp. 495-528
-
-
Drummond, D.C.1
Noble, C.O.2
Kirpotin, D.B.3
Guo, Z.4
Scott, G.K.5
Benz, C.C.6
-
68
-
-
0032499756
-
Hodin RA (1998) p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells
-
Archer SY, Meng S, Shei A, Hodin RA (1998) p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. Proc Natl Acad Sci U S A 95:6791–6796.
-
Proc Natl Acad Sci U S A
, vol.95
, pp. 6791-6796
-
-
Archer, S.Y.1
Meng, S.2
Shei, A.3
-
69
-
-
37149022209
-
Review article: The role of butyrate on colonic function
-
Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ (2008) Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 27:104–119.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 104-119
-
-
Hamer, H.M.1
Jonkers, D.2
Venema, K.3
Vanhoutvin, S.4
Troost, F.J.5
Brummer, R.J.6
-
70
-
-
59149103242
-
Butyrate modulates oxidative stress in the colonic mucosa of healthy humans
-
Hamer HM, Jonkers DM, Bast A, Vanhoutvin SA, Fischer MA, Kodde A, Troost FJ, Venema K, Brummer RJ (2009) Butyrate modulates oxidative stress in the colonic mucosa of healthy humans. Clin Nutr 28:88–93.
-
(2009)
Clin Nutr
, vol.28
, pp. 88-93
-
-
Hamer, H.M.1
Jonkers, D.M.2
Bast, A.3
Vanhoutvin, S.A.4
Fischer, M.A.5
Kodde, A.6
Troost, F.J.7
Venema, K.8
Brummer, R.J.9
-
71
-
-
33847279583
-
Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells
-
Sauer J, Richter KK, Pool-Zobel BL (2007) Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem 18:736–745.
-
(2007)
J Nutr Biochem
, vol.18
, pp. 736-745
-
-
Sauer, J.1
Richter, K.K.2
Pool-zobel, B.L.3
-
72
-
-
51849099492
-
The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells
-
Spurling CC, Suhl JA, Boucher N, Nelson CE, Rosenberg DW, Giardina C (2008) The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells. Nutr Cancer 60:692–702.
-
(2008)
Nutr Cancer
, vol.60
, pp. 692-702
-
-
Spurling, C.C.1
Suhl, J.A.2
Boucher, N.3
Nelson, C.E.4
Rosenberg, D.W.5
Giardina, C.6
-
73
-
-
0037156959
-
Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy
-
Lambert DW, Wood IS, Ellis A, Shirazi- Beechey SP (2002) Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer 86:1262–1269.
-
(2002)
Br J Cancer
, vol.86
, pp. 1262-1269
-
-
Lambert, D.W.1
Wood, I.S.2
Ellis, A.3
Shirazi- Beechey, S.P.4
-
74
-
-
79958178888
-
SLC5A8 gene, a transporter of butyrate: A gut fl ora metabolite, is frequently methylated in African American colon adenomas
-
Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H (2011) SLC5A8 gene, a transporter of butyrate: a gut fl ora metabolite, is frequently methylated in African American colon adenomas. PLoS One 6:e20216.
-
(2011)
PLoS One
, vol.6
, pp. e20216
-
-
Brim, H.1
Kumar, K.2
Nazarian, J.3
Hathout, Y.4
Jafarian, A.5
Lee, E.6
Green, W.7
Smoot, D.8
Park, J.9
Nouraie, M.10
Ashktorab, H.11
-
75
-
-
33845898832
-
Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors
-
Camacho LH, Olson J, Tong WP, Young CW, Spriggs DR, Malkin MG (2007) Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors. Invest New Drugs 25:131–138.
-
(2007)
Invest New Drugs
, vol.25
, pp. 131-138
-
-
Camacho, L.H.1
Olson, J.2
Tong, W.P.3
Young, C.W.4
Spriggs, D.R.5
Malkin, M.G.6
-
76
-
-
0034796871
-
A phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule
-
Carducci MA, Gilbert J, Bowling MK, Noe D, Eisenberger MA, Sinibaldi V, Zabelina Y, Chen TL, Grochow LB, Donehower RC (2001) A phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. Clin Cancer Res 7:3047–3055.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3047-3055
-
-
Carducci, M.A.1
Gilbert, J.2
Bowling, M.K.3
Noe, D.4
Eisenberger, M.A.5
Sinibaldi, V.6
Zabelina, Y.7
Chen, T.L.8
Grochow, L.B.9
Donehower, R.C.10
-
77
-
-
34447304130
-
Valproic acid (VPA) in patients with refractory advanced cancer: A dose escalating phase I clinical trial
-
Atmaca A, Al-Batran SE, Maurer A, Neumann A, Heinzel T, Hentsch B, Schwarz SE, Hövelmann S, Göttlicher M, Knuth A, Jäger E (2007) Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial. Br J Cancer 97:177–182.
-
(2007)
Br J Cancer
, vol.97
, pp. 177-182
-
-
Atmaca, A.1
Al-batran, S.E.2
Maurer, A.3
Neumann, A.4
Heinzel, T.5
Hentsch, B.6
Schwarz, S.E.7
Hövelmann, S.8
Göttlicher, M.9
Knuth, A.10
Jäger, E.11
-
79
-
-
67651153048
-
New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
-
Cang S, Ma Y, Liu D (2009) New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer. J Hematol Oncol 2:22.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 22
-
-
Cang, S.1
Ma, Y.2
Liu, D.3
-
80
-
-
33847258674
-
Discovery and development of SAHA as an anticancer agent
-
Marks PA (2007) Discovery and development of SAHA as an anticancer agent. Oncogene 26:1351–1356.
-
(2007)
Oncogene
, vol.26
, pp. 1351-1356
-
-
Marks, P.A.1
-
81
-
-
0037015071
-
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin- binding protein-2, and downregulates thioredoxin
-
Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM (2002) The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin- binding protein-2, and downregulates thioredoxin. Proc Natl Acad Sci U S A 99:11700–11705.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11700-11705
-
-
Butler, L.M.1
Zhou, X.2
Xu, W.S.3
Scher, H.I.4
Rifkind, R.A.5
Marks, P.A.6
Richon, V.M.7
-
82
-
-
50249095068
-
Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
-
Vansteenkiste J, Van Cutsem E, Dumez H, Chen C, Ricker JL, Randolph SS, Schöffski P (2008) Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs 26:483–488.
-
(2008)
Invest New Drugs
, vol.26
, pp. 483-488
-
-
Vansteenkiste, J.1
Van Cutsem, E.2
Dumez, H.3
Chen, C.4
Ricker, J.L.5
Randolph, S.S.6
Schöffski, P.7
-
83
-
-
77952310681
-
Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: The Pelvic Radiation and Vorinostat (PRAVO) phase 1 study
-
Ree AH, Dueland S, Folkvord S, Hole KH, Seierstad T, Johansen M, Abrahamsen TW, Flatmark K (2010) Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study. Lancet Oncol 11:459–464.
-
(2010)
Lancet Oncol
, vol.11
, pp. 459-464
-
-
Ree, A.H.1
Dueland, S.2
Folkvord, S.3
Hole, K.H.4
Seierstad, T.5
Johansen, M.6
Abrahamsen, T.W.7
Flatmark, K.8
-
84
-
-
79953765656
-
Gastrointestinal toxicity of vorinostat: Reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy
-
Bratland A, Dueland S, Hollywood D, Flatmark K, Ree AH (2011) Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy. Radiat Oncol 6:33.
-
(2011)
Radiat Oncol
, vol.6
, pp. 33
-
-
Bratland, A.1
Dueland, S.2
Hollywood, D.3
Flatmark, K.4
Ree, A.H.5
-
85
-
-
54049130432
-
Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells
-
Lee EJ, Lee BB, Kim SJ, Park YD, Park J, Kim DH (2008) Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int J Oncol 33:767–776.
-
(2008)
Int J Oncol
, vol.33
, pp. 767-776
-
-
Lee, E.J.1
Lee, B.B.2
Kim, S.J.3
Park, Y.D.4
Park, J.5
Kim, D.H.6
-
86
-
-
79956101962
-
The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models
-
LaBonte MJ, Wilson PM, Fazzone W, Russell J, Louie SG, El-Khoueiry A, Lenz HJ, Ladner RD (2011) The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models. Cancer Res 71:3635–3648.
-
(2011)
Cancer Res
, vol.71
, pp. 3635-3648
-
-
Labonte, M.J.1
Wilson, P.M.2
Fazzone, W.3
Russell, J.4
Louie, S.G.5
El-khoueiry, A.6
Lenz, H.J.7
Ladner, R.D.8
-
87
-
-
0344431240
-
FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor
-
Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S (1998) FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 241: 126–133.
-
(1998)
Exp Cell Res
, vol.241
, pp. 126-133
-
-
Nakajima, H.1
Kim, Y.B.2
Terano, H.3
Yoshida, M.4
Horinouchi, S.5
-
88
-
-
59149098431
-
A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors
-
Doss H, Jones S, Infante J, Spigel D, Willcutt N, Lamar R, Barton J, Keegan M, Burris HA (2008) A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors. J Clin Oncol 26(suppl):2567.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2567
-
-
Doss, H.1
Jones, S.2
Infante, J.3
Spigel, D.4
Willcutt, N.5
Lamar, R.6
Barton, J.7
Keegan, M.8
Burris, H.A.9
-
89
-
-
0034326799
-
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin
-
Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW, Lee HW (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res 60:6068–6074.
-
(2000)
Cancer Res
, vol.60
, pp. 6068-6074
-
-
Han, J.W.1
Ahn, S.H.2
Park, S.H.3
Wang, S.Y.4
Bae, G.U.5
Seo, D.W.6
Kwon, H.K.7
Hong, S.8
Lee, H.Y.9
Lee, Y.W.10
Lee, H.W.11
-
90
-
-
0037822085
-
Histone deacetylase inhibitors in cancer therapy
-
Rosato RR, Grant S (2003) Histone deacetylase inhibitors in cancer therapy. Cancer Biol Ther 2:30–37.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 30-37
-
-
Rosato, R.R.1
Grant, S.2
-
91
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK (2001) Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1:194–202.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
92
-
-
0033551152
-
A synthetic inhibitor of histone deacetylase, MS-27–275, with marked in vivo antitumor activity against human tumors
-
Saito A, Yamashita T, Mariko Y, Nosaka Y, Tsuchiya K, Ando T, Suzuki T, Tsuruo T, Nakanishi O (1999) A synthetic inhibitor of histone deacetylase, MS-27–275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A 96:4592–4597.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 4592-4597
-
-
Saito, A.1
Yamashita, T.2
Mariko, Y.3
Nosaka, Y.4
Tsuchiya, K.5
Ando, T.6
Suzuki, T.7
Tsuruo, T.8
Nakanishi, O.9
-
93
-
-
0033614993
-
Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives
-
Suzuki T, Ando T, Tsuchiya K, Fukazawa N, Saito A, Mariko Y, Yamashita T, Nakanishi O (1999) Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. J Med Chem 42:3001–3003.
-
(1999)
J Med Chem
, vol.42
, pp. 3001-3003
-
-
Suzuki, T.1
Ando, T.2
Tsuchiya, K.3
Fukazawa, N.4
Saito, A.5
Mariko, Y.6
Yamashita, T.7
Nakanishi, O.8
-
94
-
-
70350443118
-
Phase I/II: The oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors
-
Hurwitz H, Nelson B, O’Dwyer P, Chiorean E, Gabrail N, Li Z, Laille E, Drouin M, Rothenberg ML, Chan E (2008) Phase I/II: the oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors. J Clin Oncol 26(suppl):4625.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4625
-
-
Hurwitz, H.1
Nelson, B.2
O’dwyer, P.3
Chiorean, E.4
Gabrail, N.5
Li, Z.6
Laille, E.7
Drouin, M.8
Rothenberg, M.L.9
Chan, E.10
-
95
-
-
28244459182
-
Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: An epidemiological perspective
-
Seow A, Vainio H, Yu MC (2005) Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective. Mutat Res 592:58–67.
-
(2005)
Mutat Res
, vol.592
, pp. 58-67
-
-
Seow, A.1
Vainio, H.2
Yu, M.C.3
-
96
-
-
34047136753
-
Cruciferous vegetables and human cancer risk: Epidemiologic evidence and mechanistic basis
-
Higdon JV, Delage B, Williams DE, Dashwood RH (2007) Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res 55:224–236.
-
(2007)
Pharmacol Res
, vol.55
, pp. 224-236
-
-
Higdon, J.V.1
Delage, B.2
Williams, D.E.3
Dashwood, R.H.4
-
97
-
-
70350714439
-
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: A prospective study of men in Shanghai
-
Moy KA, Yuan JM, Chung FL, Wang XL, Van Den Berg D, Wang R, Gao YT, Yu MC (2009) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai. Chin Int J Cancer 125:2652–2659.
-
(2009)
Chin Int J Cancer
, vol.125
, pp. 2652-2659
-
-
Moy, K.A.1
Yuan, J.M.2
Chung, F.L.3
Wang, X.L.4
Van Den Berg, D.5
Wang, R.6
Gao, Y.T.7
Yu, M.C.8
-
98
-
-
84927695260
-
Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer. Int J Cancer
-
Ishikawa S, Hayashi H, Kinoshita K, Abe M, Kuroki H, Tokunaga R, Tomiyasu S, Tanaka H, Sugita H, Arita T, Yagi Y, Watanabe M, Hirota M, Baba H (2013) Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer. Int J Cancer. doi: 10.1002/ ijc.28672 (Ahead of print).
-
(2013)
Ijc.28672 (Ahead of print)
-
-
Ishikawa, S.1
Hayashi, H.2
Kinoshita, K.3
Abe, M.4
Kuroki, H.5
Tokunaga, R.6
Tomiyasu, S.7
Tanaka, H.8
Sugita, H.9
Arita, T.10
Yagi, Y.11
Watanabe, M.12
Hirota, M.13
Baba, H.14
-
99
-
-
80053557393
-
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell “stemness” via the bone morphogenetic protein pathway
-
Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JC (2011) Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell “stemness” via the bone morphogenetic protein pathway. Gut 60:1544–1553.
-
(2011)
Gut
, vol.60
, pp. 1544-1553
-
-
Kodach, L.L.1
Jacobs, R.J.2
Voorneveld, P.W.3
Wildenberg, M.E.4
Verspaget, H.W.5
Van Wezel, T.6
Morreau, H.7
Hommes, D.W.8
Peppelenbosch, M.P.9
Van Den Brink, G.R.10
Hardwick, J.C.11
-
100
-
-
79959820766
-
An overview of epigenetics and chemoprevention
-
Huang YW, Kuo CT, Stoner K, Huang TH, Wang LS (2011) An overview of epigenetics and chemoprevention. FEBS Lett 585: 2129–2136.
-
(2011)
FEBS Lett
, vol.585
, pp. 2129-2136
-
-
Huang, Y.W.1
Kuo, C.T.2
Stoner, K.3
Huang, T.H.4
Wang, L.S.5
-
101
-
-
84880763160
-
Epigenetics meets radiation biology as a new approach in cancer treatment
-
Kim JG, Park MT, Heo K, Yang KM, Yi JM (2013) Epigenetics meets radiation biology as a new approach in cancer treatment. Int J Mol Sci 14:15059–15073
-
(2013)
Int J Mol Sci
, vol.14
, pp. 15059-15073
-
-
Kim, J.G.1
Park, M.T.2
Heo, K.3
Yang, K.M.4
Yi, J.M.5
|