Slc5a8 gene, a transporter of butyrate: A gut flora metabolite, is frequently methylated in african american colon adenomas

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Brim, Hassan ^a   Kumar, Krishan ^a   Nazarian, Javad ^b   Hathout, Yetrib ^b   Jafarian, Amir ^a   Lee, Edward ^a   Green, William ^a   Smoot, Duane ^a   Park, Jong ^c   Nouraie, Mehdi ^a   Ashktorab, Hassan ^a  

^a HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HISTONE; SODIUM GLUCOSE COTRANSPORTER 8; UNCLASSIFIED DRUG; BUTYRIC ACID DERIVATIVE; CATION TRANSPORT PROTEIN; SLC5A8 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AFRICAN AMERICAN; AGE; ARTICLE; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON ADENOMA; COLON POLYPOSIS; CONTROLLED STUDY; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MICROSATELLITE INSTABILITY; PROTEIN EXPRESSION; PROTEOMICS; SEX; SLC5A8 GENE; VILLOUS ADENOMA; ADENOMA; AGING; COLON TUMOR; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; SEXUAL DEVELOPMENT;

ADENOMA; AFRICAN AMERICANS; AGING; BUTYRATES; CATION TRANSPORT PROTEINS; COLONIC NEOPLASMS; DNA METHYLATION; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; PROTEOMICS; SEX CHARACTERISTICS; TUMOR MARKERS, BIOLOGICAL;

EID: 79958178888     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020216     Document Type: Article

References (27)

1. Jemal A, Center MM, DeSantis C, Ward EM, (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19: 1893-1907.
2. Jemal A, Siegel R, Xu J, Ward E, (2010) Cancer statistics, 2010. CA Cancer J Clin 60: 277-300.
3. Nouraie M, Hosseinkhah F, Brim H, Zamanifekri B, Smoot DT, et al. (2010) Clinicopathological features of colon polyps from African-Americans. Dig Dis Sci 55: 1442-1449.
4. Ashktorab H, Smoot DT, Carethers JM, Rahmanian M, Kittles R, et al. (2003) High incidence of microsatellite instability in colorectal cancer from African Americans. Clin Cancer Res 9: 1112-1117.
5. Ashktorab H, Smoot DT, Farzanmehr H, Fidelia-Lambert M, Momen B, et al. (2005) Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. Int J Cancer 116: 914-919.
6. Kumar K, Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, et al. (2009) Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans. Clin Cancer Res In press. pp. 68.
7. Li H, Gilbert ER, Zhang Y, Crasta O, Emmerson D, et al. (2008) Expression profiling of the solute carrier gene family in chicken intestine from the late embryonic to early post-hatch stages. Anim Genet 39: 407-424.
8. Bennett KL, Karpenko M, Lin MT, Claus R, Arab K, et al. (2008) Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res 68: 4494-4499.
9. Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, et al. (2003) SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A 100: 8412-8417.
10. Park JY, Helm JF, Zheng W, Ly QP, Hodul PJ, et al. (2008) Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. Pancreas 36: e32-39.
11. Park JY, Zheng W, Kim D, Cheng JQ, Kumar N, et al. (2007) Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. Cancer Detect Prev 31: 359-365.
12. Thangaraju M, Cresci G, Itagaki S, Mellinger J, Browning DD, et al. (2008) Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer. J Gastrointest Surg.
13. Whitman SP, Hackanson B, Liyanarachchi S, Liu S, Rush LJ, et al. (2008) DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood 112: 2013-2016.
14. Nazarian J, Santi M, Hathout Y, Macdonald TJ, (2008) Protein profiling of formalin fixed paraffin embedded tissue: Identification of potential biomarkers for pediatric brainstem glioma. Proteomics Clin Appl 2: 915-924.
15. Deng G, Kakar S, Tanaka H, Matsuzaki K, Miura S, et al. (2008) Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics. Eur J Cancer 44: 1290-1301.
16. Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, et al. (2008) Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J 10: 193-199.
17. Kumar K, Daremipouran M, Brim H, Mokarram P, Smoot DT, et al.eds. (2009) CAN1 gene methylation profile in African Americans with colon cancer and adenoma, new candidate genes.
18. El-Maarri O, Becker T, Junen J, Manzoor SS, Diaz-Lacava A, et al. (2007) Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. Hum Genet 122: 505-514.
19. Brim H, Mokarram P, Naghibalhossaini F, Saberi-Firoozi M, Al-Mandhari M, et al. (2008) Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. Mol Cancer 7: 68.
20. Dong SM, Lee EJ, Jeon ES, Park CK, Kim KM, (2005) Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod Pathol 18: 170-178.
21. Goldstein NS, (2006) Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification. Am J Clin Pathol 125: 146-153.
22. Ueno M, Toyota M, Akino K, Suzuki H, Kusano M, et al. (2004) Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer. Tumour Biol 25: 134-140.
23. Ashktorab H, Belgrave K, Hosseinkhah F, Brim H, Nouraie M, et al. (2009) Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig Dis Sci 54: 2109-2117.
24. Kim HS, Vanoosthuyse V, Fillingham J, Roguev A, Watt S, et al. (2009) An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Nat Struct Mol Biol 16: 1286-1293.
25. Li RW, Li C, (2006) Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells. BMC Genomics 7: 234.
26. Ashktorab H, Brim H, Smoot DT, (2008) Distinct CIN and MIN pattern, CAN1 gene methylation profile in African-Americans (AA) with colon cancer and adenoma. Gastroenterology pp. 134-A617.
27. Schuebel KE, Chen W, Cope L, Glockner SC, Suzuki H, et al. (2007) Comparing the DNA hypermethylome with gene mutations in human colorectal cancer. PLoS Genet 3: 1709-1723.