Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-D-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1026, Issue , 2016, Pages 124-133

  Cai, Yu ^a   Li, Sai ^a   Li, Ting ^a   Zhou, Ruina ^a   Wai, Alfred Tai Seng ^a   Yan, Ru ^a  

^a University of Macau   (Macao)

Author keywords

Hepatic glucuronidation; Intestinal permeability; Isomerization; Microbial metabolism; Scutellaria Radix; Systemic exposure

Indexed keywords

FLAVONOIDS; ISOMERIZATION; ISOMERS; METABOLISM; PHARMACOKINETICS; RATS;

GLUCURONIDATION; INTESTINAL PERMEABILITIES; MICROBIAL METABOLISM; SCUTELLARIA RADIX; SYSTEMIC EXPOSURE;

PLANT EXTRACTS;

5,7,8 TRIHYDROXYLFLAVONE; 8 GLUCURONIDE; AGLYCONE; BAICALEIN; BAICALEIN 5 O GLUCURONIDE; BAICALEIN 6 GLUCOSE 7 O BETA GLUCOPYRANURONOSIDE; BAICALIN; FORMONONETIN; GLUCURONIDE; OROXYLIN A; OROXYLIN A 7 O BETA DEXTRO GLUCURONIDE; SCUTELLARIAE RADIX; UNCLASSIFIED DRUG; WOGONIN; WOGONOSIDE; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; GLUCOSIDE; OROXYLIN A-7-O-GLUCURONIDE; PLANT EXTRACT; SCUTELLARIA BAICALENSIS EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; APPARENT PERMEABILITY; AREA UNDER THE CURVE; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; DEGLYCOSYLATION; DEMETHYLATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG PENETRATION; DRUG TRANSFORMATION; DRUG TRANSPORT; GLUCURONIDATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLORA; ISOMER; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROBIAL METABOLISM; NONHUMAN; PHARMACOKINETIC PARAMETERS; PLASMA CONCENTRATION-TIME CURVE; PLASMA PEAK AREA RATIO TIME CURVE; PRIORITY JOURNAL; RAT; SCUTELLARIA; SCUTELLARIA BAICALENSIS; TANDEM MASS SPECTROMETRY; ANIMAL; CACO-2 CELL LINE; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVANONES; FLAVONES; FLAVONOIDS; GLUCOSIDES; GLUCURONIDES; HUMANS; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84955279389     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2015.11.049     Document Type: Article

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