HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine

Analytical Biochemistry

Volumn 350, Issue 1, 2006, Pages 99-104

  Kotani, Akira ^a   Kojima, Satoshi ^a   Hakamata, Hideki ^a   Kusu, Fumiyo ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Baicalein; Baicalin; Electrochemical detection; Microbore column; Rat plasma; Saiko keishi to

Indexed keywords

CHEMICAL DETECTION; HYDROLYSIS; PHARMACOKINETICS; RATS; SULFUR COMPOUNDS;

BAICALEIN; BAICALIN; ELECTROCHEMICAL DETECTION; MICROBORE COLUMNS; RAT PLASMA; SAIKO-KEISHI-TO;

FLAVONOIDS;

ACETIC ACID ETHYL ESTER; BAICALEIN; BAICALIN; BETA GLUCURONIDASE; DRUG METABOLITE; KAMPO; PHOSPHORIC ACID; SAIKO KA RYUKOTSU BOREI TO; SULFATASE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG HYDROLYSIS; ELECTROCHEMICAL DETECTION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL NOISE RATIO;

ANIMALIA;

EID: 32644486652     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2005.11.007     Document Type: Article

References (18)

1. H.M. Chang, and P.P.H. But Pharmacology and Applications of Chinese Materia Medica vol. 2 1987 World Scientific Publishing Singapore
2. T. Nakajima, M. Imanishi, K. Yamamoto, J.C. Cyong, and K. Hirai Inhibitory effect of baicalein, a flavonoid in Scutellaria root, on eotaxin production by human dermal fibroblasts Planta Med. 67 2001 132 135
3. K. Kitamura, M. Honda, H. Yoshizaki, S. Yamamoto, H. Nakane, M. Fukushima, K. Ono, and T. Tokunaga Baicalin, an inhibitor of HIV-1 production in vitro Antiviral Res. 37 1998 131 140
4. Y. Matsuzaki, N. Kurokawa, S. Terai, Y. Matsumura, N. Kobayashi, and K. Okita Cell death induced by baicalein in human hepatocellular carcinoma cell lines Jpn. J. Cancer Res. 87 1996 170 177
5. F.L. Chan, H.L. Choi, Z.Y. Chen, P.S. Chan, and Y. Huang Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin Cancer Lett. 160 2000 219 228
6. S. Ikemoto, K. Sugimura, N. Yoshida, R. Yasumoto, S. Wada, K. Yamamoto, and T. Kishimoto Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines Urology 55 2000 951 955
7. Z. Gao, K. Huang, X. Yang, and H. Xu Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi Biochim. Biophys. Acta 1472 1999 643 650
8. D.E. Shieh, L.T. Liu, and C.C. Lin Antioxidant and free radical scavenging effects of baicalein, baicalin, and wogonin Anticancer Res. 20 2000 2861 2865
9. Z.L. Liu, S. Tanaka, H. Horigome, T. Hirano, and K. Oka Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites Biol. Pharm. Bull. 25 2002 37 41
10. T. Akao, K. Kawabata, E. Yanagisawa, K. Ishihara, Y. Mizuhara, Y. Wakui, Y. Sakashita, and K. Kobashi Baicalin, the predominant flavone glucuronide of Scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form J. Pharm. Pharmacol. 52 2000 1563 1568
11. M.Y. Lai, S.L. Hsiu, S.Y. Tsai, Y.C. Hou, and P.D.L. Chao Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats J. Pharm. Pharmacol. 55 2003 205 209
12. L. Zhang, G. Lin, and Z. Zuo High-performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma J. Pharm. Biomed. Anal. 36 2004 637 641
13. R. Muto, T. Motozuka, M. Nakano, Y. Tatsumi, F. Sakamoto, and N. Kosaka The chemical structure of new substance as the metabolite of baicalin and time profiles for the plasma concentration after oral administration of Sho-saiko-to in human Yakugaku Zasshi 118 1998 79 87
14. F. Zuo, Z.M. Zhou, Q. Zhang, D. Mao, Y.L. Xiong, Y.L. Wang, M.Z. Yan, and M.L. Liu Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats Biol. Pharm. Bull. 26 2003 911 919
15. M.Y. Lai, S.L. Hsiu, C.C. Chen, Y.C. Hou, and P.D.L. Chao Urinary pharmacokinetics of baicalein, wogonin, and their glycosides after oral administration of Scutellariae radix in humans Biol. Pharm. Bull. 26 2003 79 83
16. J. Xing, X. Chen, Y. Sun, Y. Luan, and D. Zhong Interaction of baicalin and baicalein with antibiotics in the gastrointestinal tract J. Pharm. Pharmacol. 57 2005 743 750
17. Z. Sun, Z. Ma, W. Zhang, X. Wang, C. Fan, and G. Li Electrochemical investigations of baicalin and DNA-baicalin interactions Anal. Bioanal. Chem. 379 2004 283 286
18. K. Abe, O. Inoue, and E. Yumioka Biliary excretion of metabolites of baicalin and baicalein in rats Chem. Pharm. Bull. 38 1990 209 211