Pharmacokinetic interactions among major bioactive components in Radix Scutellariae via metabolic competition

Biopharmaceutics and Drug Disposition

Volumn 33, Issue 9, 2012, Pages 487-500

  Li, Chen Rui ^a,b   Zhang, Li ^a   Wo, Siu Kwan ^a   Zhou, Li Min ^a   Lin, Ge ^a   Zuo, Zhong ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

interaction; metabolism; pharmacokinetics; Radix Scutellariae

Indexed keywords

3,7 DIHYDROXYFLAVONE; BAICALEIN; BAICALIN; FLAVONE DERIVATIVE; GLUCURONOSYLTRANSFERASE 1A9; OROXYLIN A; OROXYLIN A 7 O GLUCURONIDE; SCUTELLARIAE RADIX; UNCLASSIFIED DRUG; WOGONIN; WOGONOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME KINETICS; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINE PERFUSION; MALE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE TRANSPORT; MONOLAYER CULTURE; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CACO-2 CELLS; DOGS; DRUG INTERACTIONS; FLAVANONES; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MADIN DARBY CANINE KIDNEY CELLS; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SCUTELLARIA BAICALENSIS; SULFATES;

EID: 84871032395     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1815     Document Type: Article

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