Hepatic metabolism and disposition of baicalein via the coupling of conjugation enzymes and transporters-in vitro and in vivo evidences

AAPS Journal

Volumn 13, Issue 3, 2011, Pages 378-389

  Zhang, Li ^a   Li, Chenrui ^a   Lin, Ge ^b   Krajcsi, Peter ^c,d   Zuo, Zhong ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^c SOLVO BIOTECHNOLOGY   (Hungary)

^d Rational Drug Design Laboratories   (Hungary)

Author keywords

baicalein; conjugation; hepatic metabolism; transporters

Indexed keywords

BAICALEIN; BAICALEIN 7 O GLUCURONIDE; BETA GLUCURONIDASE; DRUG METABOLITE; ISOPROTEIN; METHYL O BAICALEIN O GLUCURONIDE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1B3; ORGANIC ANION TRANSPORTER 2B1; SULFATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG MEGADOSE; DRUG METABOLISM; DRUG STRUCTURE; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIVER METABOLISM; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; PROTEIN FUNCTION; RAT; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BILE; BIOTRANSFORMATION; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LIVER; MALE; METABOLIC DETOXICATION, PHASE II; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 80052584684     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9277-6     Document Type: Article

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