A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6641-6650

  Ikeuchi, Hideyuki ^a   Meyer, Megan E ^b   Ding, Yun ^b   Hiratake, Jun ^a   Richards, Nigel G J ^b  

^a KYOTO UNIVERSITY   (Japan)

^b University of Florida ^*  (United States)

Author keywords

Asparagine synthetase; Enzyme inhibitors; Leukemia; Structure activity relationship; Sulfoximine synthesis; Transition state analogs

Indexed keywords

ASPARTATE AMMONIA LIGASE; ENZYME INHIBITOR; RHODIUM; SULFANILAMIDE; SULFOXIDE; SULFOXIMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYST; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME KINETICS; LEUKEMIA; MOLECULAR MODEL; STEADY STATE; STRUCTURE ACTIVITY RELATION;

ASPARTATE-AMMONIA LIGASE; CATALYSIS; HUMANS; METHIONINE SULFOXIMINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RHODIUM; SULFONAMIDES; SULFOXIDES;

EID: 69249123826     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.071     Document Type: Article

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