Exploring the Mechanism of β-Lactam Ring Protonation in the Class A β-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography

Journal of Medicinal Chemistry

Volumn 59, Issue 1, 2016, Pages 474-479

  Vandavasi, Venu Gopal ^a   Weiss, Kevin L ^a   Cooper, Jonathan B ^b   Erskine, Peter T ^b   Tomanicek, Stephen J ^a   Ostermann, Andreas ^c   Schrader, Tobias E ^d   Ginell, Stephan L ^e   Coates, Leighton ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d FORSCHUNGSZENTRUM JÜLICH   (Germany)

^e ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CEFOTAXIME; ENZYME; GLUTAMIC ACID; LIGAND; LYSINE; PROTEIN; SERINE; ANTIINFECTIVE AGENT; BETA LACTAM; ENZYME INHIBITOR;

ACYLATION; ARTICLE; CATALYSIS; CONFORMATION; DEACYLATION; ENZYME STRUCTURE; NEUTRON; PROTEIN STRUCTURE; PROTON TRANSPORT; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVE SITE; GENETICS; METABOLISM; MUTATION; NEUTRON DIFFRACTION; PROTEIN CONFORMATION; SYNTHESIS;

ACYLATION; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BETA-LACTAMS; CATALYSIS; CATALYTIC DOMAIN; CEFOTAXIME; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; MUTATION; NEUTRON DIFFRACTION; PROTEIN CONFORMATION;

EID: 84955112630     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01215     Document Type: Article

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